ES2075315T3 - Procedimiento para la preparacion de acidos (6s)- y (6r)-tetrahidrofolicos. - Google Patents

Procedimiento para la preparacion de acidos (6s)- y (6r)-tetrahidrofolicos.

Info

Publication number
ES2075315T3
ES2075315T3 ES91121326T ES91121326T ES2075315T3 ES 2075315 T3 ES2075315 T3 ES 2075315T3 ES 91121326 T ES91121326 T ES 91121326T ES 91121326 T ES91121326 T ES 91121326T ES 2075315 T3 ES2075315 T3 ES 2075315T3
Authority
ES
Spain
Prior art keywords
acid
acids
preparation
tetrahydrofolic
addition salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91121326T
Other languages
English (en)
Inventor
Hans Rudolf Muller
Martin Ulmann
Josef Conti
Gunter Murdel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eprova AG
Original Assignee
Eprova AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eprova AG filed Critical Eprova AG
Application granted granted Critical
Publication of ES2075315T3 publication Critical patent/ES2075315T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Abstract

LA INVENCION TRATA DE UN METODO PARA LA ELABORACION DE ACIDOS DE TETRAHIDROFOL DE (6S) Y DE (6R) Y DE SUS SALES DE ADICION CON UN ACIDO SULFONICO O CON ACIDO DE AZUFRE, EL CUAL SE CARACTERIZA PORQUE EL ACIDO DE TETRAHIDROFOL DE (6R, S) SE TRANSFORMA CON UN ACIDO SULFONICO O CON UN ACIDO DE AZUFRE, CRISTALIZANDOSE DE FORMA FRACCIONADA LA SAL DE ADICION DE ACIDO OBTENIDA Y SI SE DESEA, SE DEJA LIBRE Y SE AISLA LOS ACIDOS DE TETRAHIDROFOL DE (6R) MEDIANTE EL TRATAMIENTO CON UNA BASE DE LAS SALES DE ADICION DEL ACIDO DIASTEREOMERAS. LA INVENCION TRATA ADEMAS DE NUEVAS SALES DE ADICION DE ACIDOS DE ACIDOS DE TETRAHIDROFOL DE (6S) Y DE (6R) CON UN ACIDO SULFONICO O CON UN ACIDO DE AZUFRE, EL CUAL SE UTILIZA COMO MEDICAMENTO O COMO MATERIAL DE PARTIDA PARA LA ELABORACION DE UN MEDICAMENTO O PARA LA ELABORACION DE ACIDOS ACTIVOS Y OPTICOS DE 5-METILO, 5-FORMIL Y DE 5,10-ACIDOS DE METILENTETRAHIDROFOL, ASI COMO SUS SALES Y SUS FUERTES BASES.
ES91121326T 1991-01-16 1991-12-12 Procedimiento para la preparacion de acidos (6s)- y (6r)-tetrahidrofolicos. Expired - Lifetime ES2075315T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH108/91A CH681303A5 (es) 1991-01-16 1991-01-16

Publications (1)

Publication Number Publication Date
ES2075315T3 true ES2075315T3 (es) 1995-10-01

Family

ID=4179454

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91121326T Expired - Lifetime ES2075315T3 (es) 1991-01-16 1991-12-12 Procedimiento para la preparacion de acidos (6s)- y (6r)-tetrahidrofolicos.

Country Status (25)

Country Link
US (1) US5324836A (es)
EP (1) EP0495204B1 (es)
JP (1) JPH0739417B2 (es)
KR (1) KR100207133B1 (es)
CN (1) CN1030079C (es)
AT (1) ATE123777T1 (es)
AU (1) AU654993B2 (es)
CA (1) CA2059103C (es)
CH (1) CH681303A5 (es)
DE (1) DE59105722D1 (es)
DK (1) DK0495204T3 (es)
ES (1) ES2075315T3 (es)
FI (1) FI109906B (es)
GE (1) GEP19971019B (es)
HU (1) HU207083B (es)
IE (1) IE72164B1 (es)
IL (1) IL100478A (es)
LV (1) LV10083B (es)
MX (1) MX9200063A (es)
NO (1) NO301422B1 (es)
NZ (1) NZ241245A (es)
PT (1) PT100014B (es)
RU (1) RU2099340C1 (es)
TW (1) TW198033B (es)
ZA (1) ZA92291B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH682664A5 (en) * 1991-10-15 1993-10-29 Eprova Ag Stable salts of 5,10-methylene tetrahydrofolate.
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
CH683262A5 (it) * 1992-01-22 1994-02-15 Applied Pharma Res Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico).
IT1254635B (it) * 1992-02-20 1995-09-28 Bracco Spa Processo per la separazione degli stereoisomeri dell'acido folinico
CH684644A5 (de) 1992-07-13 1994-11-15 Eprova Ag 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen.
CH686672A5 (de) * 1992-12-01 1996-05-31 Cerbios Pharma Sa Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
CH686369A5 (de) * 1994-05-09 1996-03-15 Eprova Ag Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.
CH689831A5 (de) * 1995-11-07 1999-12-15 Eprova Ag Stabile kristalline Tetrahydrofolsaeure-Salze.
CH693905A5 (de) 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH695217A5 (de) * 1999-07-14 2006-01-31 Merck Eprova Ag Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure.
CH694251A5 (de) * 1999-07-14 2004-10-15 Eprova Ag Herstellung von Tetrahydropterin und Derivaten.
AU2002241918B2 (en) 2001-01-16 2007-01-18 Gr Intellectual Reserve, Llc Enhanced data storage and retrieval devices and systems and methods for utilizing the same
ITMI20020132A1 (it) 2002-01-25 2003-07-25 Gmt Fine Chemicals Sa Processo per l'ottenimento dell'acido (6s)-5,6,7,8-tetraidrofolico
AU2003303150A1 (en) 2002-11-21 2004-07-14 Berkshire Laboratories, Inc. Enhanced data storage and retrieval devices and systems and methods for utilizing same
CH696717A5 (de) * 2004-02-20 2007-10-31 Cerbios Pharma Sa Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
CH698729B1 (de) * 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
CN101407518A (zh) * 2007-10-11 2009-04-15 南京莱尔生物化工有限公司 (6r,s)-5-甲酰-四氢叶酸的拆分及其成盐的方法
JP5925381B2 (ja) 2012-04-13 2016-05-25 ▲連雲▼港金康和信▲薬業▼有限公司Ｌｉａｎｙｕｎｇａｎｇ Ｊｉｎｋａｎｇ Ｈｅｘｉｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． 化合物［４−（２−アミノ−１０−メチル−４−オキソ−６，７，８，９−テトラヒドロ−４ａ，７−エピミノピリミド［４，５−ｂ］［１，４］ジアゼピン−５（４Ｈ）−イル）ベンゾイル］−グルタメート及びその製造
CN104045640B (zh) * 2013-03-14 2016-04-06 天津康鸿医药科技发展有限公司 一种制备高纯度左亚叶酸钙的方法
CN104774169B (zh) * 2014-01-15 2017-02-15 上海韶远试剂有限公司 一种利用非手性助剂进行非对映异构体拆分的新方法
CN108164531B (zh) * 2018-02-12 2019-11-05 江苏红豆杉药业有限公司 一种l-5-甲基四氢叶酸钙的制备方法
CN112351818A (zh) 2018-07-06 2021-02-09 默克专利股份有限公司 5-甲基-(6s)-四氢叶酸和l-异亮氨酸乙酯的结晶盐

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468886A (en) * 1967-10-23 1969-09-23 Us Health Education & Welfare Tetrahydrohomofolic acid sulfate and synthesis thereof
DE2063027A1 (de) * 1969-12-26 1971-07-01 Yamanouchi Pharmaceutical Co Ltd , Tokio Salz einer basischen Aminosäure der 5 6,7,8 Tetrahydrofolsaure
JPS4832120A (es) * 1971-08-31 1973-04-27
US4665176A (en) * 1984-10-23 1987-05-12 Mitsui Toatsu Chemicals, Incorporated Process for the preparation of 5,6,7,8-tetrahydrofolic acid
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (es) * 1987-05-15 1990-03-15 Eprova Ag
DE3821875C1 (es) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
JPH0265787A (ja) * 1988-08-30 1990-03-06 Kyowa Hakko Kogyo Co Ltd Ｌ（‐）‐テトラヒドロ葉酸の製造法
CH676981A5 (es) * 1988-11-11 1991-03-28 Eprova Ag
FR2643081B1 (fr) * 1989-02-14 1991-06-07 Panmedica Sa Folates de magnesium, procede de preparation et compositions pharmaceutiques
US5173488A (en) * 1989-08-21 1992-12-22 American Cyanamid Company Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method
DE69027585T2 (de) * 1989-12-11 1997-01-16 American Cyanamid Co Verfahren zur Herstellung von optisch reinen Diastereoisomeren von Tetrahydrofolatverbindungen
CH680731A5 (es) * 1990-04-12 1992-10-30 Sapec Fine Chemicals

Also Published As

Publication number Publication date
LV10083A (lv) 1994-05-10
CN1063285A (zh) 1992-08-05
CN1030079C (zh) 1995-10-18
HUT60272A (en) 1992-08-28
HU9200134D0 (en) 1992-04-28
TW198033B (es) 1993-01-11
NO920197D0 (no) 1992-01-15
FI920180A (fi) 1992-07-17
ZA92291B (en) 1992-09-30
RU2099340C1 (ru) 1997-12-20
GEP19971019B (en) 1997-05-22
IE72164B1 (en) 1997-03-26
NO301422B1 (no) 1997-10-27
FI109906B (fi) 2002-10-31
KR920014812A (ko) 1992-08-25
EP0495204A1 (de) 1992-07-22
US5324836A (en) 1994-06-28
PT100014A (pt) 1993-03-31
NO920197L (no) 1992-07-17
LV10083B (en) 1995-04-20
IL100478A0 (en) 1992-09-06
JPH04312586A (ja) 1992-11-04
KR100207133B1 (ko) 1999-07-15
MX9200063A (es) 1993-01-01
CA2059103C (en) 1996-12-17
EP0495204B1 (de) 1995-06-14
CA2059103A1 (en) 1992-07-17
IE920112A1 (en) 1992-07-29
HU207083B (en) 1993-03-01
AU654993B2 (en) 1994-12-01
DE59105722D1 (de) 1995-07-20
CH681303A5 (es) 1993-02-26
DK0495204T3 (da) 1995-08-07
IL100478A (en) 1999-03-12
NZ241245A (en) 1993-11-25
ATE123777T1 (de) 1995-06-15
AU1025492A (en) 1992-07-23
JPH0739417B2 (ja) 1995-05-01
FI920180A0 (fi) 1992-01-15
PT100014B (pt) 1999-08-31

Similar Documents

Publication Publication Date Title
ES2075315T3 (es) Procedimiento para la preparacion de acidos (6s)- y (6r)-tetrahidrofolicos.
HUT58322A (en) Process for producing new n-(3-hydroxy-4-piperidinyl)-dihydro-benzofurane-, -dihydro-2h-penzopyrane- and -dihydro-benzodioxine-carboxamide derivatives and pharmaceutical compositions containing them
DK496089A (da) Biologisk aktive phenylalkansyreforbindelser og fremgangsmaade til fremstilling deraf
NO874350D0 (no) Fremgangsmaate for fremstilling av antibakterielle forbindelser.
DE3873578D1 (de) Verwendung von tetrahydrobenz(c,d)indol-6-carboxamiden zur herstellung von arzneimitteln zur behandlung von angstzustaenden.
ES2052714T3 (es) Un proceso para la preparacion de un compuesto denominado "cornexistina".
ES2053856T3 (es) Derivados del acido 4-quinoleino carboxilico utiles para el tratamiento de enfermedades de la piel y del muco-epitelio.
ES545194A0 (es) Un procedimiento para preparar derivados de purina
JPS6442472A (en) Quinazoline derivative, production thereof and brain function disorder improving agent containing said derivative as active ingredient
ES2065928T3 (es) Procedimiento para la fabricacion de derivados de acido 2,6-diclorodifenilaminacetico.
HUT46292A (en) Process for production of new salts of aryl-oxi-propanol-amines formed by diphenyl acetic acid
HUT51597A (en) Process for production of derivatives of n,n-disubstituated diaryl-alcane-carbonic acid amid and medical compositions containing them as active substances
GR3006606T3 (es)
ES2066052T3 (es) Esteres del acido cinamico.
ZA88640B (en) Novel imidazo-and triazolothiadiazines,a process for the preparation thereof,medicaments containing same,and the use thereof,and some intermediates formed in the preparation of the compounds mentioned
HUT47900A (en) Process for producing new amides of butenic acid and pharmaceutical compositions containing them as active components
HUT45062A (en) Process for producing 1-hydroxy-5-oxo-5h-pindo/3,2-a/ phenoxazine-3-carboxylic acid esters and pharmaceuticals comprising the same as active ingredient
ES540982A0 (es) Un procedimiento para la preparacion de cis-3,3,5-trimetil- ciclohexil-d,l-alda-(3-piridincarboxi)-fenilacetato
ATE132865T1 (de) 3-anilino-2-hydroxycarbonyl-4-thiophenessigsäur n
JPS5555165A (en) N-(benzoylmercapto substituted acyl)-histidine

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 495204

Country of ref document: ES