ES2118870T3 - Procedimiento para la purificacion de acido clavulanico en bruto. - Google Patents

Procedimiento para la purificacion de acido clavulanico en bruto.

Info

Publication number
ES2118870T3
ES2118870T3 ES93116779T ES93116779T ES2118870T3 ES 2118870 T3 ES2118870 T3 ES 2118870T3 ES 93116779 T ES93116779 T ES 93116779T ES 93116779 T ES93116779 T ES 93116779T ES 2118870 T3 ES2118870 T3 ES 2118870T3
Authority
ES
Spain
Prior art keywords
clavulanic acid
purification
raw
procedure
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93116779T
Other languages
English (en)
Inventor
Ho Suk Yang
Nam Hee Choi
Sang Chul Lee
Yun Beom Ham
Kyeong Bok Min
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PHARMA DEV Ltd
Original Assignee
PHARMA DEV Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PHARMA DEV Ltd filed Critical PHARMA DEV Ltd
Application granted granted Critical
Publication of ES2118870T3 publication Critical patent/ES2118870T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA LA PREPARACION DE ACIDO CLAVULANICO PURO Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE SE UTILIZA UNA SAL AMINA DEL ACIDO COMO INTERMEDIARIA
ES93116779T 1992-10-21 1993-10-18 Procedimiento para la purificacion de acido clavulanico en bruto. Expired - Lifetime ES2118870T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR920019353 1992-10-21

Publications (1)

Publication Number Publication Date
ES2118870T3 true ES2118870T3 (es) 1998-10-01

Family

ID=19341504

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93116779T Expired - Lifetime ES2118870T3 (es) 1992-10-21 1993-10-18 Procedimiento para la purificacion de acido clavulanico en bruto.

Country Status (16)

Country Link
EP (1) EP0594099B1 (es)
JP (1) JPH06197782A (es)
KR (1) KR100200239B1 (es)
AT (1) ATE167677T1 (es)
AU (1) AU669212B2 (es)
CA (1) CA2107928A1 (es)
CZ (1) CZ221193A3 (es)
DE (1) DE69319296T2 (es)
DK (1) DK0594099T3 (es)
ES (1) ES2118870T3 (es)
GR (1) GR3027699T3 (es)
HU (1) HUT66020A (es)
NZ (1) NZ248917A (es)
PL (1) PL300747A1 (es)
SI (1) SI9300556A (es)
ZA (1) ZA937638B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
GB2282810B (en) * 1992-06-11 1997-02-26 Smithkline Beecham Plc Preparation or purification of clavulanic acid
DK0658558T3 (da) 1993-11-17 2001-04-17 Biochemie Gmbh Adskillelse af cephalosporinisomere
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
EP0937084A1 (en) * 1996-11-11 1999-08-25 Gist-Brocades B.V. Process for the preparation of salts and esters of clavulanic acid
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
DZ2456A1 (fr) 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
EP1095046A1 (en) * 1998-07-16 2001-05-02 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid
DK1284978T4 (da) * 2000-05-13 2009-01-05 Smithkline Beecham Plc Fremgangsmåde til oprensning af et salt af clavulansyre
CN108558909B (zh) * 2018-05-17 2019-09-17 国药集团威奇达药业有限公司 综合回收克拉维酸叔丁胺盐结晶母液中有效成分的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1543563A (en) * 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
BE862211A (fr) * 1977-12-22 1978-06-22 Beecham Group Ltd Agents antibacteriens
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline

Also Published As

Publication number Publication date
KR940009194A (ko) 1994-05-20
HU9302876D0 (en) 1993-12-28
DE69319296D1 (de) 1998-07-30
GR3027699T3 (en) 1998-11-30
ATE167677T1 (de) 1998-07-15
CA2107928A1 (en) 1994-04-22
EP0594099B1 (en) 1998-06-24
CZ221193A3 (en) 1994-05-18
DK0594099T3 (da) 1999-02-15
PL300747A1 (en) 1994-05-16
AU669212B2 (en) 1996-05-30
SI9300556A (en) 1994-06-30
KR100200239B1 (ko) 1999-06-15
AU4900893A (en) 1994-05-05
HUT66020A (en) 1994-08-29
EP0594099A1 (en) 1994-04-27
ZA937638B (en) 1994-05-05
DE69319296T2 (de) 1998-11-05
NZ248917A (en) 1995-08-28
JPH06197782A (ja) 1994-07-19

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