PL239590A1 - Process for preparing novel derivatives of penicicillin and inhibitor of beta-lactomase connected with bis-hydroxymethyl bridge - Google Patents

Process for preparing novel derivatives of penicicillin and inhibitor of beta-lactomase connected with bis-hydroxymethyl bridge

Info

Publication number
PL239590A1
PL239590A1 PL23959082A PL23959082A PL239590A1 PL 239590 A1 PL239590 A1 PL 239590A1 PL 23959082 A PL23959082 A PL 23959082A PL 23959082 A PL23959082 A PL 23959082A PL 239590 A1 PL239590 A1 PL 239590A1
Authority
PL
Poland
Prior art keywords
beta
bis
hydroxymethyl
bridge
inhibitor
Prior art date
Application number
PL23959082A
Other versions
PL140375B1 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PL239590A1 publication Critical patent/PL239590A1/en
Publication of PL140375B1 publication Critical patent/PL140375B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/06—Preparation of esters of carbonic or haloformic acids from organic carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Abstract

Antibacterial agents in which a penicillin and a beta-lactamase inhibitor are linked by means of a bis-hydroxymethyl carbonate bridge are of the formula: <IMAGE> (I) and pharmaceutically acceptable acid addition salts thereof, wherein R1 is hydrogen, hydroxy, certain acyloxy or certain alkoxycarbonyloxy groups, a method for their use, pharmaceutical compositions thereof, and intermediates useful in their production.
PL1982239590A 1981-12-22 1982-12-17 Process for preparing novel derivatives of penicicillin and inhibitor of beta-lactomase connected with bis-hydroxymethyl bridge PL140375B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/334,017 US4359472A (en) 1981-12-22 1981-12-22 Bis-hydroxymethyl carbonate bridged antibacterial agents
AU23672/84A AU560708B2 (en) 1981-12-22 1984-01-20 Penicillin intermediates

Publications (2)

Publication Number Publication Date
PL239590A1 true PL239590A1 (en) 1985-01-16
PL140375B1 PL140375B1 (en) 1987-04-30

Family

ID=25619060

Family Applications (2)

Application Number Title Priority Date Filing Date
PL1982248638A PL140731B1 (en) 1981-12-22 1982-12-17 Method of obtaining new penicillin derivatives
PL1982239590A PL140375B1 (en) 1981-12-22 1982-12-17 Process for preparing novel derivatives of penicicillin and inhibitor of beta-lactomase connected with bis-hydroxymethyl bridge

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL1982248638A PL140731B1 (en) 1981-12-22 1982-12-17 Method of obtaining new penicillin derivatives

Country Status (25)

Country Link
US (1) US4359472A (en)
EP (1) EP0082666B1 (en)
JP (1) JPS58116490A (en)
KR (1) KR860001362B1 (en)
AT (1) ATE17853T1 (en)
AU (2) AU535634B2 (en)
CS (1) CS236779B2 (en)
DD (3) DD216024A5 (en)
DE (1) DE3269029D1 (en)
DK (1) DK565582A (en)
EG (1) EG15866A (en)
ES (3) ES518490A0 (en)
FI (1) FI75570C (en)
GR (1) GR77097B (en)
HU (1) HU188825B (en)
IE (1) IE54334B1 (en)
IL (1) IL67523A (en)
NO (2) NO160300C (en)
NZ (1) NZ202855A (en)
PH (1) PH18490A (en)
PL (2) PL140731B1 (en)
PT (1) PT76011B (en)
SU (2) SU1217261A3 (en)
YU (1) YU42823B (en)
ZA (1) ZA829375B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4359472A (en) * 1981-12-22 1982-11-16 Pfizer Inc. Bis-hydroxymethyl carbonate bridged antibacterial agents
US4434173A (en) * 1982-08-23 1984-02-28 Pfizer Inc. Bis-esters of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole as antibacterial agents
US4448732A (en) * 1982-09-07 1984-05-15 Pfizer Inc. 2-Oxo-1,3-dioxol-4-ylmethyl esters of penicillanic acid 1,1-dioxide
US4530792A (en) * 1982-11-01 1985-07-23 Pfizer Inc. Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate
CN112724162B (en) * 2020-12-28 2022-06-10 华南农业大学 Synthesis method and application of amoxicillin-sulbactam hybrid molecule

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985648A (en) * 1958-10-06 1961-05-23 Doyle Frank Peter Alpha-aminobenzylpenicillins
BE639104A (en) * 1962-11-02
US3520876A (en) * 1967-11-01 1970-07-21 American Home Prod Process for the preparation of 6-(alpha-aminoacylamino)penicillanic acids
DE2228670A1 (en) * 1971-06-15 1973-01-11 Yamanouchi Pharma Co Ltd NEW OXYMETHYLESTER DERIVATIVES OF PENICILLIN AND CEPHALOSPORIN
GB1425827A (en) * 1972-03-13 1976-02-18 Astra Laekemedel Ab Penicillins and cephalosporins
ES436565A1 (en) * 1974-06-05 1977-04-01 Bristol Myers Co Enzymatic preparation of 6-d-(')-' -amino-' -(p-hydroxyphenylacetamino)penicillin acid
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
IE49880B1 (en) 1979-02-13 1986-01-08 Leo Pharm Prod Ltd Penicillin derivatives
KR830001903B1 (en) * 1979-02-13 1983-09-19 레오 파마슈티칼 프로덕츠 리미티드 Method for producing peniclanate derivative
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4359472A (en) * 1981-12-22 1982-11-16 Pfizer Inc. Bis-hydroxymethyl carbonate bridged antibacterial agents

Also Published As

Publication number Publication date
AU535634B2 (en) 1984-03-29
NO160300B (en) 1988-12-27
JPH0119394B2 (en) 1989-04-11
CS236779B2 (en) 1985-05-15
SU1217261A3 (en) 1986-03-07
ATE17853T1 (en) 1986-02-15
KR860001362B1 (en) 1986-09-16
FI75570B (en) 1988-03-31
EP0082666A1 (en) 1983-06-29
IL67523A0 (en) 1983-05-15
ZA829375B (en) 1983-10-26
PL248638A1 (en) 1985-05-07
DK565582A (en) 1983-06-23
AU2367284A (en) 1984-05-10
IL67523A (en) 1986-04-29
PL140731B1 (en) 1987-05-30
AU560708B2 (en) 1987-04-16
PL140375B1 (en) 1987-04-30
PT76011B (en) 1985-12-13
ES8402157A1 (en) 1984-02-01
HU188825B (en) 1986-05-28
PH18490A (en) 1985-08-02
ES524779A0 (en) 1985-01-01
DD216024A5 (en) 1984-11-28
ES8502119A1 (en) 1984-12-16
ES8502443A1 (en) 1985-01-01
DE3269029D1 (en) 1986-03-20
NO160300C (en) 1989-04-05
NO832871L (en) 1983-06-23
YU280082A (en) 1985-04-30
PT76011A (en) 1983-01-01
EP0082666B1 (en) 1986-02-05
DD222315A5 (en) 1985-05-15
GR77097B (en) 1984-09-06
NO824304L (en) 1983-06-23
ES518490A0 (en) 1984-02-01
EG15866A (en) 1986-09-30
ES524778A0 (en) 1984-12-16
YU42823B (en) 1988-12-31
IE823035L (en) 1983-06-22
AU9172282A (en) 1983-08-04
US4359472A (en) 1982-11-16
JPS58116490A (en) 1983-07-11
SU1169541A3 (en) 1985-07-23
FI824408A0 (en) 1982-12-21
NZ202855A (en) 1985-09-13
DD208621A5 (en) 1984-04-04
IE54334B1 (en) 1989-08-30
FI824408L (en) 1983-06-23
FI75570C (en) 1988-07-11

Similar Documents

Publication Publication Date Title
DE69319296T2 (en) Process for the purification of raw clavulanic acid
PL239590A1 (en) Process for preparing novel derivatives of penicicillin and inhibitor of beta-lactomase connected with bis-hydroxymethyl bridge
NO982107L (en) Preparation of a salt of clavulanic acid
SE7906681L (en) FTALAZONDERIVAT
ATE17729T1 (en) NEW CEPHALOSPORIN DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE AND INTERMEDIATE PRODUCTS THEREOF, AND RELEVANT PHARMACEUTICAL PREPARATIONS.
ES476259A1 (en) Penicillanic acid derivatives, processes for their preparation and pharmaceutical compositions containing them.
BR9810031A (en) Pyrrolidine carboxylic acid derivatives as endothelin antagonists
FI882667A (en) FOERFARANDE FOER FRAMSTAELLNING AV ANTIBAKTERISKA VID 7-STAELLNINGEN SUBSTITUERADE 1-CYCLOPROPYL-6-FLUOR -1,4-DIHYDRO-4-OXO-1,8-NAFTYRIDIN-3-CARBOXYLSYROR.