DE69319296T2 - Verfahren zur Reinigung von roher Clavulansäure - Google Patents

Verfahren zur Reinigung von roher Clavulansäure

Info

Publication number
DE69319296T2
DE69319296T2 DE69319296T DE69319296T DE69319296T2 DE 69319296 T2 DE69319296 T2 DE 69319296T2 DE 69319296 T DE69319296 T DE 69319296T DE 69319296 T DE69319296 T DE 69319296T DE 69319296 T2 DE69319296 T2 DE 69319296T2
Authority
DE
Germany
Prior art keywords
clavulanic acid
purification
raw
acid
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69319296T
Other languages
English (en)
Other versions
DE69319296D1 (de
Inventor
Ho Suk Yang
Nam Hee Choi
Sang Chul Lee
Yun Beom Ham
Kyeong Bok Min
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PHARMA DEV Ltd
Original Assignee
PHARMA DEV Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PHARMA DEV Ltd filed Critical PHARMA DEV Ltd
Publication of DE69319296D1 publication Critical patent/DE69319296D1/de
Application granted granted Critical
Publication of DE69319296T2 publication Critical patent/DE69319296T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69319296T 1992-10-21 1993-10-18 Verfahren zur Reinigung von roher Clavulansäure Expired - Fee Related DE69319296T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR920019353 1992-10-21

Publications (2)

Publication Number Publication Date
DE69319296D1 DE69319296D1 (de) 1998-07-30
DE69319296T2 true DE69319296T2 (de) 1998-11-05

Family

ID=19341504

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69319296T Expired - Fee Related DE69319296T2 (de) 1992-10-21 1993-10-18 Verfahren zur Reinigung von roher Clavulansäure

Country Status (16)

Country Link
EP (1) EP0594099B1 (de)
JP (1) JPH06197782A (de)
KR (1) KR100200239B1 (de)
AT (1) ATE167677T1 (de)
AU (1) AU669212B2 (de)
CA (1) CA2107928A1 (de)
CZ (1) CZ221193A3 (de)
DE (1) DE69319296T2 (de)
DK (1) DK0594099T3 (de)
ES (1) ES2118870T3 (de)
GR (1) GR3027699T3 (de)
HU (1) HUT66020A (de)
NZ (1) NZ248917A (de)
PL (1) PL300747A1 (de)
SI (1) SI9300556A (de)
ZA (1) ZA937638B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
GB2282810B (en) * 1992-06-11 1997-02-26 Smithkline Beecham Plc Preparation or purification of clavulanic acid
DK0658558T3 (da) 1993-11-17 2001-04-17 Biochemie Gmbh Adskillelse af cephalosporinisomere
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
EP0937084A1 (de) * 1996-11-11 1999-08-25 Gist-Brocades B.V. Verfahren zur herstellung von clavulansäure-salzen und estern
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
DZ2456A1 (fr) 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
EP1095046A1 (de) * 1998-07-16 2001-05-02 Dsm N.V. Verbessertes verfahren zur herstellung von clavulansäure-salzen und -estern
DK1284978T4 (da) * 2000-05-13 2009-01-05 Smithkline Beecham Plc Fremgangsmåde til oprensning af et salt af clavulansyre
CN108558909B (zh) * 2018-05-17 2019-09-17 国药集团威奇达药业有限公司 综合回收克拉维酸叔丁胺盐结晶母液中有效成分的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1543563A (en) * 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
BE862211A (fr) * 1977-12-22 1978-06-22 Beecham Group Ltd Agents antibacteriens
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline

Also Published As

Publication number Publication date
KR940009194A (ko) 1994-05-20
HU9302876D0 (en) 1993-12-28
DE69319296D1 (de) 1998-07-30
GR3027699T3 (en) 1998-11-30
ATE167677T1 (de) 1998-07-15
CA2107928A1 (en) 1994-04-22
EP0594099B1 (de) 1998-06-24
ES2118870T3 (es) 1998-10-01
CZ221193A3 (en) 1994-05-18
DK0594099T3 (da) 1999-02-15
PL300747A1 (en) 1994-05-16
AU669212B2 (en) 1996-05-30
SI9300556A (en) 1994-06-30
KR100200239B1 (ko) 1999-06-15
AU4900893A (en) 1994-05-05
HUT66020A (en) 1994-08-29
EP0594099A1 (de) 1994-04-27
ZA937638B (en) 1994-05-05
NZ248917A (en) 1995-08-28
JPH06197782A (ja) 1994-07-19

Similar Documents

Publication Publication Date Title
FI951414A (fi) Menetelmä epäpuhtaan klavulaanihapon puhdistamiseksi
DE69319296T2 (de) Verfahren zur Reinigung von roher Clavulansäure
ATE101116T1 (de) Gabapentinmonohydrat und verfahren zu dessen herstellung.
EP0291799A3 (en) Dioxyalkylenearyl-dihydropyridines and their intermediary compounds, process for their preparation and their use
DE69328962D1 (de) Verfahren zur herstellng von cyano-methoxyiminomethylderivaten
DE69221841T2 (de) Verfahren zur Herstellung von gereinigtem Xanthangummi
DE69233249D1 (de) Verfahren zur Herstellung von einem 3-Cephem-4-Carbonsäurederivat
ATE190614T1 (de) Dihydrat des n-(4-amino-6,7-dimethoxychinazol-2- yl)-n-methyl-n'-(tetrahydrofuroyl-2)- propylendiamin hydrochlorids(=alfuzosin hydrochlorid dihydrat) und ein verfahren zur herstellung
GB9304704D0 (en) Process for the production of clavulanic acid salts
OA09027A (fr) Procédé d'inhibition. d'un virus
HUT63734A (en) Fish-breeding method
ATE54148T1 (de) Neue cephalosporine und verfahren zu ihrer herstellung.
ATE224393T1 (de) Verfahren zur herstellung von cephalosporinen und zwischenverbindungen in diesem verfahren
DE59205377D1 (de) Mikrobiologisches Verfahren zur Herstellung von 5-Hydroxypyrazincarbonsäure
PL239590A1 (en) Process for preparing novel derivatives of penicicillin and inhibitor of beta-lactomase connected with bis-hydroxymethyl bridge
ATE179417T1 (de) Glyceraldehyd-3-pentanid und verfahren zu ihrer herstellung
ATE110730T1 (de) Verfahren zur herstellung von cephalosporinen.
DE59302496D1 (de) Verfahren zur Herstellung von Alkalisalzen der 3-Sulfobenzoesäure
ATE164573T1 (de) Verfahren zur herstellung von 1-unsubstituierten 3-aminopyrrolen
ATE132865T1 (de) 3-anilino-2-hydroxycarbonyl-4-thiophenessigsäur n
ES2095831T3 (es) Acidos tetrahidro-4-fenilimino-3-tiofeno-aceticos.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee