ATE101116T1 - Gabapentinmonohydrat und verfahren zu dessen herstellung. - Google Patents

Gabapentinmonohydrat und verfahren zu dessen herstellung.

Info

Publication number
ATE101116T1
ATE101116T1 AT89107795T AT89107795T ATE101116T1 AT E101116 T1 ATE101116 T1 AT E101116T1 AT 89107795 T AT89107795 T AT 89107795T AT 89107795 T AT89107795 T AT 89107795T AT E101116 T1 ATE101116 T1 AT E101116T1
Authority
AT
Austria
Prior art keywords
production
novel
gabapentin
gabapentin monohydrate
monohydrate
Prior art date
Application number
AT89107795T
Other languages
English (en)
Inventor
Donald Eugene Butler
Barbara Jean Greenman
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22694659&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE101116(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE101116T1 publication Critical patent/ATE101116T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT89107795T 1988-05-02 1989-04-28 Gabapentinmonohydrat und verfahren zu dessen herstellung. ATE101116T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/188,819 US4894476A (en) 1988-05-02 1988-05-02 Gabapentin monohydrate and a process for producing the same
EP89107795A EP0340677B1 (de) 1988-05-02 1989-04-28 Gabapentinmonohydrat und Verfahren zu dessen Herstellung

Publications (1)

Publication Number Publication Date
ATE101116T1 true ATE101116T1 (de) 1994-02-15

Family

ID=22694659

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89107795T ATE101116T1 (de) 1988-05-02 1989-04-28 Gabapentinmonohydrat und verfahren zu dessen herstellung.

Country Status (12)

Country Link
US (1) US4894476A (de)
EP (1) EP0340677B1 (de)
JP (1) JP2619951B2 (de)
AT (1) ATE101116T1 (de)
AU (1) AU624130B2 (de)
CA (1) CA1306755C (de)
DE (1) DE68912819T2 (de)
DK (1) DK175400B1 (de)
ES (1) ES2061774T3 (de)
FI (1) FI892067A (de)
HK (1) HK1000798A1 (de)
IE (1) IE62958B1 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU633612B2 (en) * 1989-08-25 1993-02-04 Warner-Lambert Company Improved process for cyclic amino acid anticonvulsant compounds
DE3928183A1 (de) * 1989-08-25 1991-02-28 Goedecke Ag Lactamfreie cyclische aminosaeuren
DE3928182A1 (de) * 1989-08-25 1991-02-28 Goedecke Ag Verfahren zur herstellung von gabapentin
DE3928184A1 (de) * 1989-08-25 1991-02-28 Goedecke Ag Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte
EP0458751A1 (de) * 1990-05-25 1991-11-27 Warner-Lambert Company System zur Freisetzung von cyclischen Aminosäuren mit verbessertem Geschmack, Struktur und Komprimierbarkeit
KR100512506B1 (ko) * 1996-03-14 2005-12-21 워너-램버트 캄파니 엘엘씨 제약제제로서신규한치환시클릭아미노산
US6372792B1 (en) 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
US6255526B1 (en) 1996-12-24 2001-07-03 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin
AU9318398A (en) 1997-10-07 1999-04-27 Warner-Lambert Company Process for preparing a cyclic amino acid anticonvulsant compound
ES2137137B1 (es) 1998-05-25 2000-08-16 Medichem Sa Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica.
ITMI981535A1 (it) * 1998-07-03 2000-01-03 Zambon Spa Processo per la preparazione di gabapentina
HU225502B1 (en) * 1998-12-29 2007-01-29 Richter Gedeon Vegyeszet Process for producing 1-(amino-metyl)-cyclohexene-acetic-acid and intermediates
IT1311984B1 (it) * 1999-03-26 2002-03-22 Bioindustria Lab Italiano Medi Procedimento per la preparzione di gabapentin.
EP1169060B1 (de) * 1999-04-09 2005-08-31 Euro-Celtique S.A. Natrium kanalblocker zusammensetzungen und deren verwendung
ES2164527B1 (es) * 1999-04-26 2003-04-01 Medichen S A Procedimiento de obtencion de gabapentina de calidad farmaceutica.
US6294198B1 (en) 1999-08-24 2001-09-25 Purepac Pharmaceutical Co. Pharmaceutical tablet formulation containing gabapentin with improved physical and chemical characteristics and method of making the same
US6333352B1 (en) 2000-04-05 2001-12-25 Mimicking Man Manually, Inc. Method of treating benign positional vertigo
EP1384473A1 (de) * 2000-06-16 2004-01-28 Teva Pharmaceutical Industries Ltd. Stabiles Gabapentin das mehr als 20 ppm Chlor enthält
WO2001097612A1 (en) * 2000-06-16 2001-12-27 Teva Pharmaceutical Industries Ltd. Stable gabapentin containing more than 2o ppm of chlorine ion
NZ523546A (en) * 2000-06-16 2005-04-29 Teva Pharma Stable pharmaceutical compositions of gabapentin having PH within the range 6.8 to 7.3 comprising less than 0.5% by weight of a corresponding lactum
ITMI20011132A1 (it) 2001-05-29 2002-11-29 Procos Spa Procedimento per la preparazione dell'acido 1-amminometil-1-cicloesanacetico
PT1423168E (pt) 2001-09-03 2006-05-31 Newron Pharm Spa Composicao farmaceutica que compreende gabapentina ou um seu analogo e uma x-aminoamida e a sua utilizacao como analgesico
US6800782B2 (en) * 2001-10-09 2004-10-05 Warner-Lambert Co. Anhydrous crystalline forms of gabapentin
US20060159743A1 (en) * 2001-10-25 2006-07-20 Depomed, Inc. Methods of treating non-nociceptive pain states with gastric retentive gabapentin
TWI312285B (en) 2001-10-25 2009-07-21 Depomed Inc Methods of treatment using a gastric retained gabapentin dosage
US7612112B2 (en) * 2001-10-25 2009-11-03 Depomed, Inc. Methods of treatment using a gastric retained gabapentin dosage
US20070184104A1 (en) * 2001-10-25 2007-08-09 Depomed, Inc. Gastric retentive gabapentin dosage forms and methods for using same
US20030119908A1 (en) * 2001-12-21 2003-06-26 Zambon Group S.P.A. Stable gabapentin compositions
US6682759B2 (en) 2002-02-01 2004-01-27 Depomed, Inc. Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs
WO2003073988A2 (en) 2002-02-28 2003-09-12 A & D Bioscience, Inc. Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof
WO2003079980A2 (en) * 2002-03-19 2003-10-02 A & D Bioscience, Inc. Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
WO2003086475A1 (en) * 2002-04-12 2003-10-23 A & D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof
US20040034248A1 (en) * 2002-04-16 2004-02-19 Taro Pharmaceutical Industries, Ltd. Process for preparing gabapentin
CA2484891A1 (en) * 2002-05-07 2003-11-20 A & D Bioscience, Inc. Conjugates comprising central nervous system active drug
US20050215487A1 (en) * 2002-06-27 2005-09-29 Holick Michael F Conjugates comprising an nsaid and a sugar and uses thereof
AU2002356424A1 (en) * 2002-11-18 2004-06-15 Nicholas Piramal India Limited Improved process for preparation of gabapentin
WO2004091278A2 (en) * 2003-04-11 2004-10-28 Transform Pharmaceuticals, Inc. Gabapentin compositions
US7439387B2 (en) * 2003-04-21 2008-10-21 Matrix Laboratories Ltd. Process for the preparation of Gabapentin form-II
US20070043236A1 (en) * 2003-05-19 2007-02-22 Chandiran Thakashina M Process for preparation of gabapentin
WO2004106281A1 (en) * 2003-05-30 2004-12-09 Ranbaxy Laboratories Limited Crystalline gabapentin
US20050013863A1 (en) 2003-07-18 2005-01-20 Depomed, Inc., A Corporation Of The State Of California Dual drug dosage forms with improved separation of drugs
US20050187295A1 (en) * 2004-02-19 2005-08-25 Surendra Kalyan Processes for the preparation of gabapentin
ITMI20040579A1 (it) * 2004-03-25 2004-06-25 Zambon Spa Processo di preparazione di gabapentina
GB0416228D0 (en) 2004-07-20 2004-08-25 Sandoz Ind Products S A Process for the preparation of gabapentin
CN101018546B (zh) * 2004-09-10 2013-06-12 纽朗制药有限公司 作为钠和/或钙通道选择性调节剂的(卤代苄氧基)苄氨基-丙酰胺类
ITMI20042418A1 (it) * 2004-12-17 2005-03-17 Zambon Spa Processo per la purificazione della gabapentina
US7071356B1 (en) * 2005-12-01 2006-07-04 Isp Investments Inc. Process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid
US20090176882A1 (en) * 2008-12-09 2009-07-09 Depomed, Inc. Gastric retentive gabapentin dosage forms and methods for using same
CA2740029C (en) * 2008-05-16 2016-12-20 Axis, Inc. Pharmaceutical composition for treatment of fibromyalgia
US8431739B2 (en) 2010-06-14 2013-04-30 Divi's Laboratories, Ltd. Process for the preparation of gabapentin
EP2923694B1 (de) 2014-03-27 2018-11-14 Sanovel Ilac Sanayi ve Ticaret A.S. Orale flüssige pharmazeutische lösung von gabapentin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
US4014175A (en) * 1975-05-05 1977-03-29 Brink Douglas F Cable and pipe laying machine
US4087594A (en) * 1977-03-21 1978-05-02 Gte Laboratories, Incorporated Reactivation of primary electrochemical cells
AU633612B2 (en) * 1989-08-25 1993-02-04 Warner-Lambert Company Improved process for cyclic amino acid anticonvulsant compounds

Also Published As

Publication number Publication date
AU624130B2 (en) 1992-06-04
DE68912819T2 (de) 1994-05-19
US4894476A (en) 1990-01-16
EP0340677B1 (de) 1994-02-02
DE68912819D1 (de) 1994-03-17
DK212689A (da) 1989-11-03
JP2619951B2 (ja) 1997-06-11
HK1000798A1 (en) 1998-05-01
DK175400B1 (da) 2004-09-27
FI892067A (fi) 1989-11-03
JPH0211546A (ja) 1990-01-16
IE62958B1 (en) 1995-03-08
EP0340677A2 (de) 1989-11-08
DK212689D0 (da) 1989-05-01
ES2061774T3 (es) 1994-12-16
IE891142L (en) 1989-11-02
AU3267889A (en) 1989-11-02
EP0340677A3 (en) 1990-12-27
FI892067A0 (fi) 1989-04-28
CA1306755C (en) 1992-08-25

Similar Documents

Publication Publication Date Title
ATE101116T1 (de) Gabapentinmonohydrat und verfahren zu dessen herstellung.
DE69120326T2 (de) Verfahren zur Herstellung eines Siliziumeinkristalles
DE69313869D1 (de) Verfahren zur Herstellung von Kalium Clavulanat
DE69214409T3 (de) Verfahren zur Herstellung unreinen Sauerstoffs
DE59303857D1 (de) Verfahren zur Herstellung von Dinitrotoluol
DE69403210T3 (de) Verfahren zur herstellung von n-acetylneuraminsäure
DE69221841T2 (de) Verfahren zur Herstellung von gereinigtem Xanthangummi
DE69319296T2 (de) Verfahren zur Reinigung von roher Clavulansäure
ATE218131T1 (de) Verfahren zur herstellung von mono-n- substituierten tetraazamakrocyclen
DE69317820D1 (de) Verfahren zur Herstellung hochreiner Monoalkylphosphine
DE69301035D1 (de) Verfahren zur Herstellung eines Silizium-Einkristalls
DE69304494T2 (de) Verfahren zur Herstellung von aktivem Magnesiumhydroxid
DE69402024D1 (de) Verfahren zur Herstellung eines Diamanthalbleiters
DE69331256T2 (de) Verfahren zur Herstellung von Chlorogalliumphtalocyaninkristallen
AU2038988A (en) A process for the manufacture of novel unsaturated amino acid compounds
DE59307005D1 (de) Verfahren zur Herstellung von Ph3C[B(C6F5)4]
DE69325742D1 (de) Verfahren zur Herstellung eines KTiOPO4-Einkristalles
DE68925459D1 (de) Verfahren zur Herstellung dünner Schichten metastabiler binärer Verbindungen
DE3883466T2 (de) Verfahren zur Herstellung kristalliner (Metallo)silikate.
FI102083B (fi) Menetelmä L-karnitiinin valmistamiseksi epäjatkuvasti mikrobiologista tietä
MX9803887A (es) Produccion de una sal de acido clavulanico.
DE69012279D1 (de) Verfahren zur Herstellung ungesättigter Verbindungen.
ATE200776T1 (de) Verfahren zur herstellung von 2,4,5-tribrompyrrol-3-carbonitril
DE69411660T2 (de) Vorrichtung zur Herstellung von Silizium-Einkristallen durch das Czochralski-Verfahren
DE69602475T2 (de) Verfahren zur Gewinnung von optisch reinen Aminosäure-Derivaten

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time