DE68912819D1 - Gabapentinmonohydrat und Verfahren zu dessen Herstellung. - Google Patents

Gabapentinmonohydrat und Verfahren zu dessen Herstellung.

Info

Publication number
DE68912819D1
DE68912819D1 DE89107795T DE68912819T DE68912819D1 DE 68912819 D1 DE68912819 D1 DE 68912819D1 DE 89107795 T DE89107795 T DE 89107795T DE 68912819 T DE68912819 T DE 68912819T DE 68912819 D1 DE68912819 D1 DE 68912819D1
Authority
DE
Germany
Prior art keywords
preparation
novel
gabapentin
gabapentin monohydrate
monohydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE89107795T
Other languages
English (en)
Other versions
DE68912819T2 (de
Inventor
Donald Eugene Butler
Barbara Jean Greenman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22694659&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE68912819(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of DE68912819D1 publication Critical patent/DE68912819D1/de
Application granted granted Critical
Publication of DE68912819T2 publication Critical patent/DE68912819T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE68912819T 1988-05-02 1989-04-28 Gabapentinmonohydrat und Verfahren zu dessen Herstellung. Expired - Lifetime DE68912819T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/188,819 US4894476A (en) 1988-05-02 1988-05-02 Gabapentin monohydrate and a process for producing the same

Publications (2)

Publication Number Publication Date
DE68912819D1 true DE68912819D1 (de) 1994-03-17
DE68912819T2 DE68912819T2 (de) 1994-05-19

Family

ID=22694659

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68912819T Expired - Lifetime DE68912819T2 (de) 1988-05-02 1989-04-28 Gabapentinmonohydrat und Verfahren zu dessen Herstellung.

Country Status (12)

Country Link
US (1) US4894476A (de)
EP (1) EP0340677B1 (de)
JP (1) JP2619951B2 (de)
AT (1) ATE101116T1 (de)
AU (1) AU624130B2 (de)
CA (1) CA1306755C (de)
DE (1) DE68912819T2 (de)
DK (1) DK175400B1 (de)
ES (1) ES2061774T3 (de)
FI (1) FI892067A (de)
HK (1) HK1000798A1 (de)
IE (1) IE62958B1 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3928182A1 (de) * 1989-08-25 1991-02-28 Goedecke Ag Verfahren zur herstellung von gabapentin
PH27359A (en) * 1989-08-25 1993-06-21 Warner Lambert Co Process for cyclic amino acid anticonvulsant compounds
DE3928184A1 (de) * 1989-08-25 1991-02-28 Goedecke Ag Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte
DE3928183A1 (de) * 1989-08-25 1991-02-28 Goedecke Ag Lactamfreie cyclische aminosaeuren
EP0458751A1 (de) * 1990-05-25 1991-11-27 Warner-Lambert Company System zur Freisetzung von cyclischen Aminosäuren mit verbessertem Geschmack, Struktur und Komprimierbarkeit
IL125544A (en) * 1996-03-14 2002-03-10 Warner Lambert Co Transformed cyclic amino acids and pharmaceutical preparations containing them
US6372792B1 (en) 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
US6255526B1 (en) 1996-12-24 2001-07-03 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin
AU9318398A (en) 1997-10-07 1999-04-27 Warner-Lambert Company Process for preparing a cyclic amino acid anticonvulsant compound
ES2137137B1 (es) 1998-05-25 2000-08-16 Medichem Sa Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica.
ITMI981535A1 (it) * 1998-07-03 2000-01-03 Zambon Spa Processo per la preparazione di gabapentina
HU225502B1 (en) * 1998-12-29 2007-01-29 Richter Gedeon Vegyeszet Process for producing 1-(amino-metyl)-cyclohexene-acetic-acid and intermediates
IT1311984B1 (it) 1999-03-26 2002-03-22 Bioindustria Lab Italiano Medi Procedimento per la preparzione di gabapentin.
EP1169060B1 (de) * 1999-04-09 2005-08-31 Euro-Celtique S.A. Natrium kanalblocker zusammensetzungen und deren verwendung
ES2164527B1 (es) * 1999-04-26 2003-04-01 Medichen S A Procedimiento de obtencion de gabapentina de calidad farmaceutica.
US6294198B1 (en) 1999-08-24 2001-09-25 Purepac Pharmaceutical Co. Pharmaceutical tablet formulation containing gabapentin with improved physical and chemical characteristics and method of making the same
US6333352B1 (en) 2000-04-05 2001-12-25 Mimicking Man Manually, Inc. Method of treating benign positional vertigo
JP2003535885A (ja) * 2000-06-16 2003-12-02 テバ ファーマシューティカル インダストリーズ リミティド 制御された範囲内にｐＨを持つ安定なギャバペンチン
US6531509B2 (en) 2000-06-16 2003-03-11 Teva Pharmaceutical Industries Ltd. Stable gabapentin containing more than 20 ppm of chlorine ion
EP1384473A1 (de) * 2000-06-16 2004-01-28 Teva Pharmaceutical Industries Ltd. Stabiles Gabapentin das mehr als 20 ppm Chlor enthält
ITMI20011132A1 (it) 2001-05-29 2002-11-29 Procos Spa Procedimento per la preparazione dell'acido 1-amminometil-1-cicloesanacetico
JP4350508B2 (ja) * 2001-09-03 2009-10-21 ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー ガバペンチンまたはその類似体とα−アミノアミドとを含む薬剤組成物およびその鎮痛用途
US6800782B2 (en) * 2001-10-09 2004-10-05 Warner-Lambert Co. Anhydrous crystalline forms of gabapentin
TWI312285B (en) 2001-10-25 2009-07-21 Depomed Inc Methods of treatment using a gastric retained gabapentin dosage
US20070184104A1 (en) * 2001-10-25 2007-08-09 Depomed, Inc. Gastric retentive gabapentin dosage forms and methods for using same
US20060159743A1 (en) * 2001-10-25 2006-07-20 Depomed, Inc. Methods of treating non-nociceptive pain states with gastric retentive gabapentin
US7612112B2 (en) 2001-10-25 2009-11-03 Depomed, Inc. Methods of treatment using a gastric retained gabapentin dosage
US20030119908A1 (en) * 2001-12-21 2003-06-26 Zambon Group S.P.A. Stable gabapentin compositions
US6682759B2 (en) 2002-02-01 2004-01-27 Depomed, Inc. Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs
US7217696B2 (en) 2002-02-28 2007-05-15 A & D Bioscience, Inc. Glycuronamides, glycosides and orthoester glycosides of fluoxetine, analogs and uses thereof
WO2003079980A2 (en) * 2002-03-19 2003-10-02 A & D Bioscience, Inc. Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
US20050255038A1 (en) * 2002-04-12 2005-11-17 A And D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents and uses thereof
AU2003262383A1 (en) * 2002-04-16 2003-11-03 Taro Pharmaceutical Industries Ltd. Process for preparing gabapentin
EP1549323A2 (de) * 2002-05-07 2005-07-06 A & D Bioscience, Inc. Konjugate mit einem wirkstoff für das zentrale nervensystem
US20050215487A1 (en) * 2002-06-27 2005-09-29 Holick Michael F Conjugates comprising an nsaid and a sugar and uses thereof
CA2472815A1 (en) * 2002-11-18 2004-06-03 Nicholas Piramal India Limited Improved process for preparation of gabapentin
US20040214893A1 (en) * 2003-04-11 2004-10-28 Matthew Peterson Gabapentin compositions
WO2004093780A2 (en) * 2003-04-21 2004-11-04 Matrix Laboratories Ltd Process for the preparation of gabapentin form-ii
US20070043236A1 (en) * 2003-05-19 2007-02-22 Chandiran Thakashina M Process for preparation of gabapentin
WO2004106281A1 (en) * 2003-05-30 2004-12-09 Ranbaxy Laboratories Limited Crystalline gabapentin
US20050013863A1 (en) 2003-07-18 2005-01-20 Depomed, Inc., A Corporation Of The State Of California Dual drug dosage forms with improved separation of drugs
US20050187295A1 (en) * 2004-02-19 2005-08-25 Surendra Kalyan Processes for the preparation of gabapentin
ITMI20040579A1 (it) * 2004-03-25 2004-06-25 Zambon Spa Processo di preparazione di gabapentina
GB0416228D0 (en) 2004-07-20 2004-08-25 Sandoz Ind Products S A Process for the preparation of gabapentin
BRPI0515154A (pt) * 2004-09-10 2008-07-08 Newron Pharm Spa uso de (halobenzilóxi)benzilamino-propanamidas para a fabricação de medicamentos ativos, compostos e composição farmacêutica
ITMI20042418A1 (it) * 2004-12-17 2005-03-17 Zambon Spa Processo per la purificazione della gabapentina
US7071356B1 (en) * 2005-12-01 2006-07-04 Isp Investments Inc. Process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid
US20090176882A1 (en) * 2008-12-09 2009-07-09 Depomed, Inc. Gastric retentive gabapentin dosage forms and methods for using same
US20110217387A1 (en) * 2008-05-16 2011-09-08 Axis, Inc. Pharmaceutical composition for treatment of fibromyalgia
US8431739B2 (en) 2010-06-14 2013-04-30 Divi's Laboratories, Ltd. Process for the preparation of gabapentin
WO2015144825A1 (en) 2014-03-27 2015-10-01 Sanovel Ilac Sanayi Ve Ticaret A.S. Oral liquid pharmaceutical solution of gabapentin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
US4014175A (en) * 1975-05-05 1977-03-29 Brink Douglas F Cable and pipe laying machine
US4087594A (en) * 1977-03-21 1978-05-02 Gte Laboratories, Incorporated Reactivation of primary electrochemical cells
PH27359A (en) * 1989-08-25 1993-06-21 Warner Lambert Co Process for cyclic amino acid anticonvulsant compounds

Also Published As

Publication number Publication date
DK212689A (da) 1989-11-03
EP0340677A2 (de) 1989-11-08
ES2061774T3 (es) 1994-12-16
CA1306755C (en) 1992-08-25
EP0340677B1 (de) 1994-02-02
IE891142L (en) 1989-11-02
FI892067A0 (fi) 1989-04-28
HK1000798A1 (en) 1998-05-01
AU3267889A (en) 1989-11-02
US4894476A (en) 1990-01-16
ATE101116T1 (de) 1994-02-15
EP0340677A3 (en) 1990-12-27
DK212689D0 (da) 1989-05-01
JPH0211546A (ja) 1990-01-16
DK175400B1 (da) 2004-09-27
AU624130B2 (en) 1992-06-04
IE62958B1 (en) 1995-03-08
JP2619951B2 (ja) 1997-06-11
DE68912819T2 (de) 1994-05-19
FI892067A (fi) 1989-11-03

Similar Documents

Publication Publication Date Title
DE68912819D1 (de) Gabapentinmonohydrat und Verfahren zu dessen Herstellung.
DE69532565D1 (de) Verfahren zur Herstellung von Isoguanosin und 2'-Derivaten davon
FI951414A (fi) Menetelmä epäpuhtaan klavulaanihapon puhdistamiseksi
DE69403210T3 (de) Verfahren zur herstellung von n-acetylneuraminsäure
AU6592790A (en) Process for the synthesis of cyclic polynitrogenated compounds
DE69319296D1 (de) Verfahren zur Reinigung von roher Clavulansäure
FI103804B1 (fi) Menetelmä tetrahydrofotolaattiyhdisteiden optisesti puhtaiden diastereoisomeerien valmistamiseksi
IE890175L (en) Aminoacid glycerides.
DE59401454D1 (de) Verfahren zur Herstellung von 13-(Z)-Retinsäure
DE69317820T2 (de) Verfahren zur Herstellung hochreiner Monoalkylphosphine
DE59404418D1 (de) Verfahren zur Herstellung von aliphatischen Omega-Difluorcarboxylverbindungen
DE69301035D1 (de) Verfahren zur Herstellung eines Silizium-Einkristalls
DE69331256T2 (de) Verfahren zur Herstellung von Chlorogalliumphtalocyaninkristallen
DE59404162D1 (de) Verfahren zur Herstellung von 9-(Z)-Retinsäure
FI883589A0 (fi) Menetelmä tyydyttämättömien aminohappoyhdisteiden valmistamiseksi
DE69329591D1 (de) Verfahren zur Herstellung wasserdispergierbarer Diclofenac enthaltender Tabletten
DE69316274D1 (de) Verfahren zur Reinigung einer Hydroxylammoniumlösung
DE69325742D1 (de) Verfahren zur Herstellung eines KTiOPO4-Einkristalles
DE59309380D1 (de) Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsäure
DE69302879D1 (de) Verfahren zur optischen Trennung von (+)-cis-4-Aminocyclopent-2-en-1-Karbonsäure-Derivaten
IE891297L (en) Amino acid esters, a process for the preparation thereof,¹pharmaceuticals containing them, and the use thereof
ATE200776T1 (de) Verfahren zur herstellung von 2,4,5-tribrompyrrol-3-carbonitril
FI945353A (fi) Entsymaattinen menetelmä (S)-6-metoksyyli-alfa-metyyli-2-naftaleenietikkahapon valmistamiseksi
DE68921138D1 (de) Verfahren zur Herstellung eines Oxidverbindungssupraleiters des Bi-Sr-Ca-Cu-Systems.
DE59407069D1 (de) Verfahren zur Herstellung von Alkalisalzen des Cyanacetons

Legal Events

Date Code Title Description
8364 No opposition during term of opposition