EP0937084A1 - Verfahren zur herstellung von clavulansäure-salzen und estern - Google Patents

Verfahren zur herstellung von clavulansäure-salzen und estern

Info

Publication number
EP0937084A1
EP0937084A1 EP97951881A EP97951881A EP0937084A1 EP 0937084 A1 EP0937084 A1 EP 0937084A1 EP 97951881 A EP97951881 A EP 97951881A EP 97951881 A EP97951881 A EP 97951881A EP 0937084 A1 EP0937084 A1 EP 0937084A1
Authority
EP
European Patent Office
Prior art keywords
clavulanic acid
amine
clavulanate
addition
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97951881A
Other languages
English (en)
French (fr)
Inventor
Johannes Booij
Antonius Van Den Heuvel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM Delft BV
Original Assignee
Gist Brocades BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades BV filed Critical Gist Brocades BV
Priority to EP97951881A priority Critical patent/EP0937084A1/de
Publication of EP0937084A1 publication Critical patent/EP0937084A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP97951881A 1996-11-11 1997-11-10 Verfahren zur herstellung von clavulansäure-salzen und estern Withdrawn EP0937084A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP97951881A EP0937084A1 (de) 1996-11-11 1997-11-10 Verfahren zur herstellung von clavulansäure-salzen und estern

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP96203117 1996-11-11
EP96203117 1996-11-11
EP97951881A EP0937084A1 (de) 1996-11-11 1997-11-10 Verfahren zur herstellung von clavulansäure-salzen und estern
PCT/EP1997/006263 WO1998021212A1 (en) 1996-11-11 1997-11-10 Process for the preparation of salts and esters of clavulanic acid

Publications (1)

Publication Number Publication Date
EP0937084A1 true EP0937084A1 (de) 1999-08-25

Family

ID=8224563

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97951881A Withdrawn EP0937084A1 (de) 1996-11-11 1997-11-10 Verfahren zur herstellung von clavulansäure-salzen und estern

Country Status (11)

Country Link
EP (1) EP0937084A1 (de)
JP (1) JP2001503763A (de)
CN (1) CN1238776A (de)
AU (1) AU5551698A (de)
BR (1) BR9713339A (de)
CA (1) CA2271847A1 (de)
NO (1) NO992225D0 (de)
PL (1) PL333247A1 (de)
TR (1) TR199901631T2 (de)
WO (1) WO1998021212A1 (de)
ZA (1) ZA9710141B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
WO2000004028A1 (en) * 1998-07-16 2000-01-27 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid
CN1209099C (zh) * 1999-04-01 2005-07-06 Dsm公司 结晶化附聚物
DE60105016T3 (de) * 2000-05-13 2009-06-25 Smithkline Beecham P.L.C., Brentford Verfahren zur reinigung eines salzes der clavulansäure
WO2008065160A1 (en) * 2006-12-01 2008-06-05 Dsm Ip Assets B.V. Process for the production of clavulanic acid

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) * 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9821212A1 *

Also Published As

Publication number Publication date
AU5551698A (en) 1998-06-03
NO992225L (no) 1999-05-07
BR9713339A (pt) 2000-05-09
CA2271847A1 (en) 1998-05-22
JP2001503763A (ja) 2001-03-21
CN1238776A (zh) 1999-12-15
PL333247A1 (en) 1999-11-22
ZA9710141B (en) 1998-06-25
NO992225D0 (no) 1999-05-07
TR199901631T2 (xx) 1999-09-21
WO1998021212A1 (en) 1998-05-22

Similar Documents

Publication Publication Date Title
JP5184465B2 (ja) クラブラン酸カリウムの製造方法
HU212583B (en) New process for producing potassium salt of clavulanic acid
RU2206613C2 (ru) Способ выделения клавулановой кислоты
EP0813536B1 (de) Verfahren zur herstellung von pharmazeutisch verträglichen salzen der clavulansäure
EP0937084A1 (de) Verfahren zur herstellung von clavulansäure-salzen und estern
EP0821687B1 (de) Herstellung von clavunalat-salzen
JPH11501023A (ja) クラブラン酸塩
EP0941229B1 (de) Reinigung von fermentierter clavulansäure
US6417352B1 (en) Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
CA2337072A1 (en) Improved process for the preparation of salts and esters of clavulanic acid
MXPA99004322A (en) Process for the preparation of salts and esters of clavulanic acid
US20010029038A1 (en) Purification of fermented clavulanic acid
WO1998042858A1 (en) Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
RU2522806C1 (ru) Усовершенствованный способ очистки правастатина
AU692091C (en) Preparation of clavulanate salts

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990427

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RAX Requested extension states of the european patent have changed

Free format text: AL PAYMENT 19990427;LT PAYMENT 19990427;LV PAYMENT 19990427;MK PAYMENT 19990427;RO PAYMENT 19990427;SI PAYMENT 19990427

17Q First examination report despatched

Effective date: 20010830

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20020312