ES2031853T3 - Un procedimiento para preparar derivados de isoquinolina sustituidos. - Google Patents

Un procedimiento para preparar derivados de isoquinolina sustituidos.

Info

Publication number
ES2031853T3
ES2031853T3 ES198787109407T ES87109407T ES2031853T3 ES 2031853 T3 ES2031853 T3 ES 2031853T3 ES 198787109407 T ES198787109407 T ES 198787109407T ES 87109407 T ES87109407 T ES 87109407T ES 2031853 T3 ES2031853 T3 ES 2031853T3
Authority
ES
Spain
Prior art keywords
hydrogen
procedure
isoquinoline derivatives
preparing substituted
substituted isoquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787109407T
Other languages
English (en)
Inventor
Kentaro 720 Uematsu-Cho Hirai
Yukio Mizushima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2031853T3 publication Critical patent/ES2031853T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN COMPUESTO DE FORMULA (I) (DONDE R ES HIDROGENO, HIDROXI, METOXI, ACETOXI, ACETOXIMETILO O TRIFLUOROMETILO; R1,R2,R3 Y R4 SON CADA UNO HIDROGENO, HIDROXI, ALCOXI C1-C5 OPCIONALMENTE SUSTITUIDO, ACETOXI, PROPINILOXI, ALILOXI O BENCILOXI; O R2 Y R3 TOMADOS JUNTOS FORMAN METILENDIOXI; R5 ES HIDROGENO, HIDROXIMETILO, ALCOXICARBONILO C2-C4, ACILOXIMETILO C2-C5 O FTALIDILO; Y N ES 0 O 1 EXCEPTO EN EL CASO EN QUE R ES METOXI Y R1,R2,R3,R4 Y R5 SON, CADA UNO, HIDROGENO). EL COMPUESTO O SUS SALES FARMACOLOGICAMENTE ACEPTABLES, QUE SON UTILES COMO AGENTES ANTIULCEROSOS, SE OBTIENE POR VARIAS VIAS.
ES198787109407T 1986-07-01 1987-06-30 Un procedimiento para preparar derivados de isoquinolina sustituidos. Expired - Lifetime ES2031853T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15541286 1986-07-01

Publications (1)

Publication Number Publication Date
ES2031853T3 true ES2031853T3 (es) 1993-01-01

Family

ID=15605425

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787109407T Expired - Lifetime ES2031853T3 (es) 1986-07-01 1987-06-30 Un procedimiento para preparar derivados de isoquinolina sustituidos.

Country Status (9)

Country Link
US (1) US4882338A (es)
EP (1) EP0251294B1 (es)
JP (1) JPH064625B2 (es)
KR (1) KR900000367B1 (es)
AT (1) ATE56717T1 (es)
AU (1) AU603810B2 (es)
DE (1) DE3765030D1 (es)
ES (1) ES2031853T3 (es)
GR (1) GR3001138T3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839365A (en) * 1987-05-19 1989-06-13 Shinogi & Co., Ltd. Thienopyridine derivatives useful in treating gastric ulcers
GB0011944D0 (en) * 2000-05-17 2000-07-05 Novartis Ag Organic compounds
GB201321746D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
JP7456621B2 (ja) * 2018-08-07 2024-03-27 慶應義塾 神経機能調節物質の動態の検出剤、及び神経機能調節物質の検出方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
CA1259070A (en) * 1983-07-01 1989-09-05 Upjohn Company (The) Substituted 2-¬monoannelated(3,4-,4,5-, and 5,6-)- pyridylalkylenesulfinyl|-benzimidazoles

Also Published As

Publication number Publication date
KR900000367B1 (ko) 1990-01-25
DE3765030D1 (de) 1990-10-25
JPS63179871A (ja) 1988-07-23
AU603810B2 (en) 1990-11-29
AU7500187A (en) 1988-01-07
KR880001637A (ko) 1988-04-25
EP0251294B1 (en) 1990-09-19
EP0251294A1 (en) 1988-01-07
JPH064625B2 (ja) 1994-01-19
GR3001138T3 (en) 1992-06-25
ATE56717T1 (de) 1990-10-15
US4882338A (en) 1989-11-21

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