ES480721A1 - Un procedimiento para aislar pseudomonato de litio. - Google Patents

Un procedimiento para aislar pseudomonato de litio.

Info

Publication number
ES480721A1
ES480721A1 ES480721A ES480721A ES480721A1 ES 480721 A1 ES480721 A1 ES 480721A1 ES 480721 A ES480721 A ES 480721A ES 480721 A ES480721 A ES 480721A ES 480721 A1 ES480721 A1 ES 480721A1
Authority
ES
Spain
Prior art keywords
isolation
hydrolysis
pseudomonate
lithium pseudomonate
lithium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES480721A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES480721A1 publication Critical patent/ES480721A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un procedimiento para aislar psudomonato de litio de fórmula **(Fórmula)** de una preparación cruda que contiene ácido pseudomónico, que comprende: a) extraer la preparación cruda con un disolvente orgánico polar, no miscible con agua, en el que es soluble el ácido pseudomónico; b) hacer reaccionar el extracto procedente de la etapa anterior con una sal de litio que sea por lo menos ligeramente soluble en el disolvente no miscible con agua; c) separar el pseudomonato de litio procedente de la etapa anterior; y d) opcionalmente, someter a reacción de hidrólisis el pseudomonato de litio obtenido para producir ácido pseudomónico.
ES480721A 1978-05-20 1979-05-18 Un procedimiento para aislar pseudomonato de litio. Expired ES480721A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2095878 1978-05-20

Publications (1)

Publication Number Publication Date
ES480721A1 true ES480721A1 (es) 1980-07-01

Family

ID=10154713

Family Applications (1)

Application Number Title Priority Date Filing Date
ES480721A Expired ES480721A1 (es) 1978-05-20 1979-05-18 Un procedimiento para aislar pseudomonato de litio.

Country Status (12)

Country Link
US (2) US4639534A (es)
EP (1) EP0005614B1 (es)
JP (1) JPS54154771A (es)
AT (1) AT364461B (es)
AU (1) AU519228B2 (es)
CA (1) CA1115699A (es)
DE (1) DE2962176D1 (es)
DK (1) DK147914C (es)
ES (1) ES480721A1 (es)
HK (1) HK55183A (es)
KE (1) KE3285A (es)
MY (1) MY8500045A (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8313035D0 (en) * 1983-05-12 1983-06-15 Beecham Group Plc Compound
GB8415579D0 (en) * 1984-06-19 1984-07-25 Beecham Group Plc Compounds
MX7417E (es) * 1984-10-27 1988-10-14 Antibioticos Sa Metodo para la preparacion de acido clavulanico y sus derivados
US5273998A (en) * 1990-05-11 1993-12-28 Yoshitomi Pharmaceutical Industries, Ltd. Process for making an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound
US5594026A (en) * 1990-12-11 1997-01-14 Smithkline Beecham Group P.L.C. Polymorphs of crystalline mupirocin
GB9026873D0 (en) * 1990-12-11 1991-01-30 Beecham Group Plc Novel compounds
HUP0105286A3 (en) 1999-02-03 2003-03-28 Biogal Gyogyszergyar Process for the isolation of pseudomonic acid a from pseudomonic acid complex-containing culture broth
TR200102234T2 (tr) 1999-02-03 2002-10-21 Biogal Gyogyszergyar Rt. Psödomonik asit A antibiyotiğinin mikrobiyolojik yöntem ile hazırlanması için işlem
CA2448547A1 (en) 2001-06-21 2003-01-03 Biogal Gyogyszergyar Rt. Metabolic controlled fermentation process for pseudomonic acid production
HUP0600679A2 (en) 2001-12-28 2008-06-30 Biogal Gyogyszergyar Processes for preparing crystalline and amorphous mupirocin calcium and pharmaceutical compositions containing the same
IL150907A (en) * 2002-07-25 2007-07-04 Stephan Cherkez Process for the preparation of stable amorphous calcium pseudomonate
ES2339682T3 (es) 2004-06-01 2010-05-24 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Procedimiento para la preparacion de la forma amorfa de un farmaco.
GB2441328A (en) * 2006-08-30 2008-03-05 Alpharma Aps A method for obtaining mupirocin calcium
US8267358B1 (en) * 2011-05-10 2012-09-18 Letson Philip D Bag holder

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR510052A (fr) * 1919-02-26 1920-11-26 Salvatore Faso Dispositif de roulement pour tracteurs à chenilles
IL30058A (en) * 1967-08-10 1972-09-28 Lilly Co Eli Process for preparing antibiotic a10388(pyrrolnitrin)
GB1395907A (en) * 1971-06-12 1975-05-29 Beecham Group Ltd Antibiotics
US4071536A (en) * 1971-06-12 1978-01-31 Beecham Group Limited Antibiotics
JPS5270083A (en) * 1975-12-04 1977-06-10 Yoshitomi Pharmaceut Ind Ltd Manufacture of an antibiotics, trans-pseudomonic acid

Also Published As

Publication number Publication date
US4639534A (en) 1987-01-27
CA1115699A (en) 1982-01-05
DK206579A (da) 1979-11-21
HK55183A (en) 1983-11-25
ATA359779A (de) 1981-03-15
EP0005614B1 (en) 1982-02-24
JPS6340192B2 (es) 1988-08-10
MY8500045A (en) 1985-12-31
JPS54154771A (en) 1979-12-06
AU519228B2 (en) 1981-11-19
KE3285A (en) 1983-06-17
DE2962176D1 (en) 1982-03-25
EP0005614A1 (en) 1979-11-28
AU4679179A (en) 1979-11-22
US4786742A (en) 1988-11-22
AT364461B (de) 1981-10-27
DK147914B (da) 1985-01-07
DK147914C (da) 1985-08-26

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