TR200102234T2 - Psödomonik asit A antibiyotiğinin mikrobiyolojik yöntem ile hazırlanması için işlem - Google Patents

Psödomonik asit A antibiyotiğinin mikrobiyolojik yöntem ile hazırlanması için işlem

Info

Publication number
TR200102234T2
TR200102234T2 TR2001/02234T TR200102234T TR200102234T2 TR 200102234 T2 TR200102234 T2 TR 200102234T2 TR 2001/02234 T TR2001/02234 T TR 2001/02234T TR 200102234 T TR200102234 T TR 200102234T TR 200102234 T2 TR200102234 T2 TR 200102234T2
Authority
TR
Turkey
Prior art keywords
pseudomonic acid
preparation
antibiotic
procedure
pseudomonas
Prior art date
Application number
TR2001/02234T
Other languages
English (en)
Inventor
Szell Valeria
Lang Ildiko
Barta Istvan
Tegdes Aniko
Albrecht Karoly
Mozes Nee Suto Julianna
M. Szabo Istvan
Petroczki Magdolna
Erdei Janos
Gulyas Eva
Balogh Gabor
Original Assignee
Biogal Gyogyszergyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt. filed Critical Biogal Gyogyszergyar Rt.
Publication of TR200102234T2 publication Critical patent/TR200102234T2/tr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/38—Pseudomonas

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Fermentasyon yoluyla havalandirma kosullarinda esas olarak saf psödomonik asit A'nin biyosentezini yapabilen bir Pseudomonas bakteryum türünün daldirmayla yetistirilmesini ve istenen bilesigin izolasyonunu içeren, psödomonik asit A'nin hazirlanmasi için bir prosedür anlatilmistir. Özelde, bu bulusun prosedürü, organik azot ve karbon kaynaklarini ve istege göre mineral tuzlarini ihtiva eden, 23-30 C arasindaki sicaklikta bir ortam üzerinde, Ulusal Tarimsal ve Endüstriyel Mikroorganizmalar Koleksiyonu, Budapeste, Macaristan adresinde NCAIM (P)B 001235 erisim sayisi altinda biriktirilen No.19/26 Pseudomonas sp. bakteryum türünün ya da bu türün psödomonik asit A-üreten mutant ya da varyantinin yetistirilmesini içermektedir.
TR2001/02234T 1999-02-03 2000-02-03 Psödomonik asit A antibiyotiğinin mikrobiyolojik yöntem ile hazırlanması için işlem TR200102234T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11845799P 1999-02-03 1999-02-03
US13733499P 1999-06-03 1999-06-03

Publications (1)

Publication Number Publication Date
TR200102234T2 true TR200102234T2 (tr) 2002-10-21

Family

ID=26816383

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02234T TR200102234T2 (tr) 1999-02-03 2000-02-03 Psödomonik asit A antibiyotiğinin mikrobiyolojik yöntem ile hazırlanması için işlem

Country Status (22)

Country Link
US (3) US6509177B1 (tr)
EP (1) EP1151131A4 (tr)
JP (1) JP2003515311A (tr)
KR (1) KR20010113674A (tr)
CN (2) CN1203184C (tr)
AU (1) AU762768B2 (tr)
BG (1) BG105776A (tr)
BR (1) BR0009179A (tr)
CA (1) CA2360865A1 (tr)
CZ (1) CZ20012724A3 (tr)
HK (1) HK1041903A1 (tr)
HR (1) HRP20010576A2 (tr)
HU (1) HUP0300363A2 (tr)
IL (2) IL144679A0 (tr)
IS (1) IS6028A (tr)
MX (1) MXPA01007806A (tr)
NO (1) NO20013791L (tr)
PL (1) PL358615A1 (tr)
SK (1) SK10892001A3 (tr)
TR (1) TR200102234T2 (tr)
WO (1) WO2000046389A1 (tr)
YU (1) YU55601A (tr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000046389A1 (en) 1999-02-03 2000-08-10 Biogal Gyogyszergyar Rt Process for the preparation of pseudomonic acid a antibiotic by microbiological method
AU2002345856A1 (en) 2001-06-21 2003-01-08 Biogal Gyogyszergyar Rt Metabolic controlled fermentation process for pseudomonic acid production
DE20220885U1 (de) * 2001-12-28 2004-06-24 BIOGAL Gyógyszergyár Rt. Kristallines und amorphes Mupirocin-Calcium
IL150907A (en) * 2002-07-25 2007-07-04 Stephan Cherkez Process for the preparation of stable amorphous calcium pseudomonate
WO2005117837A1 (en) 2004-06-01 2005-12-15 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Process for preparation of amorphous form of a drug
US7619102B2 (en) 2005-02-21 2009-11-17 Axellia Pharmaceuticals Aps Purification of mupirocin
WO2009117310A2 (en) * 2008-03-17 2009-09-24 Cedars-Sinai Medical Center Methods for treatment and prevention of mrsa/mssa
CN104370896A (zh) * 2013-11-29 2015-02-25 江苏汉邦科技有限公司 一种纯化假单孢菌素的方法
CN103820369B (zh) * 2014-03-07 2015-11-18 浙江瑞邦药业有限公司 一种萤光假单胞菌及其应用
CN108277243B (zh) * 2018-01-19 2021-03-12 浙江瑞邦药业股份有限公司 一种假单胞菌酸a的制备方法
CN108949845B (zh) * 2018-08-08 2021-08-10 福建康鸿生物科技有限公司 一种发酵培养基及由发酵培养基制备莫匹罗星的方法
CN116867905A (zh) 2021-02-07 2023-10-10 杭州中美华东制药有限公司 一种莫匹罗星的发酵方法

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GB1395907A (en) 1971-06-12 1975-05-29 Beecham Group Ltd Antibiotics
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GB1577730A (en) 1976-10-23 1980-10-29 Beecham Group Ltd Treatment of infections with pseudomonicacid salts or esters thereof
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CN1239427A (zh) 1996-10-01 1999-12-22 史密丝克莱恩比彻姆公司 Mupirocin在制备用于治疗与病原生物体鼻咽建群有关的细菌感染的药物中的应用
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Also Published As

Publication number Publication date
EP1151131A1 (en) 2001-11-07
KR20010113674A (ko) 2001-12-28
BR0009179A (pt) 2001-11-27
MXPA01007806A (es) 2003-06-04
PL358615A1 (en) 2004-08-09
CN1203184C (zh) 2005-05-25
IL144679A (en) 2007-06-17
HK1041903A1 (zh) 2002-07-26
AU762768B2 (en) 2003-07-03
CN1670217A (zh) 2005-09-21
IS6028A (is) 2001-07-31
WO2000046389A9 (en) 2001-09-07
AU2980800A (en) 2000-08-25
JP2003515311A (ja) 2003-05-07
IL144679A0 (en) 2002-06-30
YU55601A (sh) 2003-02-28
NO20013791L (no) 2001-10-02
HRP20010576A2 (en) 2002-08-31
US20030100083A1 (en) 2003-05-29
SK10892001A3 (sk) 2002-06-04
CN1354798A (zh) 2002-06-19
HUP0300363A2 (hu) 2004-06-28
CZ20012724A3 (cs) 2001-12-12
US7078223B2 (en) 2006-07-18
WO2000046389A1 (en) 2000-08-10
CA2360865A1 (en) 2000-08-10
US6509177B1 (en) 2003-01-21
EP1151131A4 (en) 2004-05-12
BG105776A (en) 2002-05-31
US20020042103A1 (en) 2002-04-11
US6506591B2 (en) 2003-01-14
NO20013791D0 (no) 2001-08-02

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