HUP0105286A2 - Eljárás pszeudomonsav A izolálására pszeudomonsav-komplex tartalmú fermentléből - Google Patents
Eljárás pszeudomonsav A izolálására pszeudomonsav-komplex tartalmú fermentlébőlInfo
- Publication number
- HUP0105286A2 HUP0105286A2 HU0105286A HUP0105286A HUP0105286A2 HU P0105286 A2 HUP0105286 A2 HU P0105286A2 HU 0105286 A HU0105286 A HU 0105286A HU P0105286 A HUP0105286 A HU P0105286A HU P0105286 A2 HUP0105286 A2 HU P0105286A2
- Authority
- HU
- Hungary
- Prior art keywords
- pseudomonic acid
- pseudomonic
- isolation
- culture broth
- containing culture
- Prior art date
Links
- MINDHVHHQZYEEK-UHFFFAOYSA-N (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-(beta)-methyl-2H-pyran-2-crotonic acid ester with 9-hydroxynonanoic acid Natural products CC(O)C(C)C1OC1CC1C(O)C(O)C(CC(C)=CC(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-UHFFFAOYSA-N 0.000 title abstract 11
- MINDHVHHQZYEEK-HBBNESRFSA-N mupirocin Chemical compound C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-HBBNESRFSA-N 0.000 title abstract 9
- 229960003128 mupirocin Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 229930194369 pseudomonic acid Natural products 0.000 title abstract 2
- 238000002955 isolation Methods 0.000 title 1
- 229930187697 mupirocin Natural products 0.000 abstract 2
- DDHVILIIHBIMQU-YJGQQKNPSA-L mupirocin calcium hydrate Chemical compound O.O.[Ca+2].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1.C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1 DDHVILIIHBIMQU-YJGQQKNPSA-L 0.000 abstract 2
- 241000589516 Pseudomonas Species 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- GJRQTCIYDGXPES-UHFFFAOYSA-N iso-butyl acetate Chemical class CC(C)COC(C)=O GJRQTCIYDGXPES-UHFFFAOYSA-N 0.000 abstract 1
- FGKJLKRYENPLQH-UHFFFAOYSA-M isocaproate Chemical class CC(C)CCC([O-])=O FGKJLKRYENPLQH-UHFFFAOYSA-M 0.000 abstract 1
- OQAGVSWESNCJJT-UHFFFAOYSA-N isovaleric acid methyl ester Chemical class COC(=O)CC(C)C OQAGVSWESNCJJT-UHFFFAOYSA-N 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
A találmány tárgya eljárás pszeudomonsav A (mupirocin) izolálásárapszeudomonsav-komplex tartalmú fermentléből. A mupirocinként is ismertpszeudomonsav A egy antibiotikum, amely a következő (I) általánosképlettel rendelkezik: A találmány szerinti eljárás a következőlépésekből áll: a Pseudomonas baktériumnemzetség pszeudomonsav A-ttermelő faj tenyészetéből savas pH-a klórozott alifás szénhidrogénvagy izobutil-acetát alkalmazásával extrahálják a pszeudomonsav A-t,oly módon, hogy pszeudomonsav A-t tartalmazó extraktumot nyernek, és apszeudomonsav A-t az extraktumból tisztítják. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11844799P | 1999-02-03 | 1999-02-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0105286A2 true HUP0105286A2 (hu) | 2002-05-29 |
| HUP0105286A3 HUP0105286A3 (en) | 2003-03-28 |
Family
ID=22378653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0105286A HUP0105286A3 (en) | 1999-02-03 | 2000-02-03 | Process for the isolation of pseudomonic acid a from pseudomonic acid complex-containing culture broth |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6245921B1 (hu) |
| EP (1) | EP1147210A4 (hu) |
| JP (1) | JP2002535996A (hu) |
| KR (1) | KR20010112258A (hu) |
| CN (1) | CN1345377A (hu) |
| AU (1) | AU771214B2 (hu) |
| BG (1) | BG105775A (hu) |
| BR (1) | BR0009178A (hu) |
| CA (1) | CA2360840A1 (hu) |
| CZ (1) | CZ20012725A3 (hu) |
| HK (1) | HK1041294A1 (hu) |
| HR (1) | HRP20010570A2 (hu) |
| HU (1) | HUP0105286A3 (hu) |
| IL (1) | IL144678A0 (hu) |
| IS (1) | IS6034A (hu) |
| MX (1) | MXPA01007805A (hu) |
| NO (1) | NO20013790L (hu) |
| PL (1) | PL349153A1 (hu) |
| SK (1) | SK10902001A3 (hu) |
| TR (1) | TR200102232T2 (hu) |
| WO (1) | WO2000046388A1 (hu) |
| YU (1) | YU55501A (hu) |
| ZA (1) | ZA200106057B (hu) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000046389A1 (en) * | 1999-02-03 | 2000-08-10 | Biogal Gyogyszergyar Rt | Process for the preparation of pseudomonic acid a antibiotic by microbiological method |
| AU2002345856A1 (en) * | 2001-06-21 | 2003-01-08 | Biogal Gyogyszergyar Rt | Metabolic controlled fermentation process for pseudomonic acid production |
| DE20220885U1 (de) * | 2001-12-28 | 2004-06-24 | BIOGAL Gyógyszergyár Rt. | Kristallines und amorphes Mupirocin-Calcium |
| IL150907A (en) * | 2002-07-25 | 2007-07-04 | Stephan Cherkez | Process for the preparation of stable amorphous calcium pseudomonate |
| WO2005117837A1 (en) * | 2004-06-01 | 2005-12-15 | Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg | Process for preparation of amorphous form of a drug |
| US7619102B2 (en) | 2005-02-21 | 2009-11-17 | Axellia Pharmaceuticals Aps | Purification of mupirocin |
| GB2441328A (en) * | 2006-08-30 | 2008-03-05 | Alpharma Aps | A method for obtaining mupirocin calcium |
| US8268975B2 (en) * | 2009-04-03 | 2012-09-18 | Dow Agrosciences Llc | Demulsification compositions, systems and methods for demulsifying and separating aqueous emulsions |
| CN104370896A (zh) * | 2013-11-29 | 2015-02-25 | 江苏汉邦科技有限公司 | 一种纯化假单孢菌素的方法 |
| CN103820369B (zh) * | 2014-03-07 | 2015-11-18 | 浙江瑞邦药业有限公司 | 一种萤光假单胞菌及其应用 |
| CN109053707B (zh) * | 2018-09-19 | 2021-08-17 | 福建康鸿生物科技有限公司 | 一种莫匹罗星的提纯方法 |
| CN110823649A (zh) * | 2019-10-21 | 2020-02-21 | 河南中烟工业有限责任公司 | 一种卷烟主流烟气中有机酸的收集方法和检测方法 |
| US20230312540A1 (en) * | 2020-08-25 | 2023-10-05 | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd | Method for extracting mupirocin |
| CN116867905A (zh) * | 2021-02-07 | 2023-10-10 | 杭州中美华东制药有限公司 | 一种莫匹罗星的发酵方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1395907A (en) | 1971-06-12 | 1975-05-29 | Beecham Group Ltd | Antibiotics |
| JPS5270083A (en) | 1975-12-04 | 1977-06-10 | Yoshitomi Pharmaceut Ind Ltd | Manufacture of an antibiotics, trans-pseudomonic acid |
| CA1103264A (en) * | 1977-09-30 | 1981-06-16 | Norman H. Rogers | Purification of pseudomonic acid |
| CA1115699A (en) | 1978-05-20 | 1982-01-05 | Alan D. Curzons | Lithium pseudomonate and its preparation |
| IS1606B (is) * | 1991-05-07 | 1996-10-18 | Sankyo Company Limited | Aðferð til framleiðslu nýs sýkladrepandi efnasambands Thiomarinol, fengið með ræktun Alteromanas rava SANK 73390 |
-
2000
- 2000-02-03 HU HU0105286A patent/HUP0105286A3/hu unknown
- 2000-02-03 KR KR1020017009823A patent/KR20010112258A/ko not_active Application Discontinuation
- 2000-02-03 SK SK1090-2001A patent/SK10902001A3/sk unknown
- 2000-02-03 BR BR0009178-2A patent/BR0009178A/pt not_active IP Right Cessation
- 2000-02-03 YU YU55501A patent/YU55501A/sh unknown
- 2000-02-03 TR TR2001/02232T patent/TR200102232T2/xx unknown
- 2000-02-03 EP EP00908467A patent/EP1147210A4/en not_active Withdrawn
- 2000-02-03 CA CA002360840A patent/CA2360840A1/en not_active Abandoned
- 2000-02-03 CN CN00805537A patent/CN1345377A/zh active Pending
- 2000-02-03 IL IL14467800A patent/IL144678A0/xx unknown
- 2000-02-03 US US09/497,806 patent/US6245921B1/en not_active Expired - Fee Related
- 2000-02-03 WO PCT/US2000/002824 patent/WO2000046388A1/en not_active Application Discontinuation
- 2000-02-03 MX MXPA01007805A patent/MXPA01007805A/es unknown
- 2000-02-03 CZ CZ20012725A patent/CZ20012725A3/cs unknown
- 2000-02-03 AU AU29802/00A patent/AU771214B2/en not_active Ceased
- 2000-02-03 PL PL00349153A patent/PL349153A1/xx not_active Application Discontinuation
- 2000-02-03 JP JP2000597447A patent/JP2002535996A/ja active Pending
-
2001
- 2001-07-24 ZA ZA200106057A patent/ZA200106057B/en unknown
- 2001-07-27 HR HR20010570A patent/HRP20010570A2/hr not_active Application Discontinuation
- 2001-08-01 IS IS6034A patent/IS6034A/is unknown
- 2001-08-02 NO NO20013790A patent/NO20013790L/no not_active Application Discontinuation
- 2001-08-03 BG BG105775A patent/BG105775A/xx active Pending
-
2002
- 2002-04-22 HK HK02103004.6A patent/HK1041294A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0009178A (pt) | 2001-11-20 |
| MXPA01007805A (es) | 2003-06-04 |
| ZA200106057B (en) | 2002-07-24 |
| US6245921B1 (en) | 2001-06-12 |
| AU771214B2 (en) | 2004-03-18 |
| EP1147210A1 (en) | 2001-10-24 |
| IS6034A (is) | 2001-08-01 |
| HRP20010570A2 (en) | 2002-08-31 |
| NO20013790D0 (no) | 2001-08-02 |
| CN1345377A (zh) | 2002-04-17 |
| KR20010112258A (ko) | 2001-12-20 |
| BG105775A (en) | 2002-03-29 |
| HK1041294A1 (zh) | 2002-07-05 |
| IL144678A0 (en) | 2002-06-30 |
| EP1147210A4 (en) | 2004-06-02 |
| JP2002535996A (ja) | 2002-10-29 |
| AU2980200A (en) | 2000-08-25 |
| CA2360840A1 (en) | 2000-08-10 |
| CZ20012725A3 (cs) | 2002-03-13 |
| WO2000046388A1 (en) | 2000-08-10 |
| SK10902001A3 (sk) | 2002-04-04 |
| YU55501A (sh) | 2003-07-07 |
| NO20013790L (no) | 2001-10-02 |
| TR200102232T2 (tr) | 2002-02-21 |
| PL349153A1 (en) | 2002-07-01 |
| HUP0105286A3 (en) | 2003-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |