BR0009178A - Processo para o isolamento de ácidopseudomÈnico a partir de ácido pseudomÈnicocomplexo contendo fluido de cultura - Google Patents
Processo para o isolamento de ácidopseudomÈnico a partir de ácido pseudomÈnicocomplexo contendo fluido de culturaInfo
- Publication number
- BR0009178A BR0009178A BR0009178-2A BR0009178A BR0009178A BR 0009178 A BR0009178 A BR 0009178A BR 0009178 A BR0009178 A BR 0009178A BR 0009178 A BR0009178 A BR 0009178A
- Authority
- BR
- Brazil
- Prior art keywords
- pseudomonic
- acid
- aqueous
- isolation
- extract
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
Abstract
"PROCESSO PARA O ISOLAMENTO DE áCIDOPSEUDOMÈNICO A PARTIR DE áCIDO PSEUDOMÈNICOCOMPLEXO CONTENDO FLUIDO DE CULTURA". é divulgadoum processo para o isolamento do antibiótico de ácidopseudomónico A de qualidade farmacêutica a partir de fluido decultura de uma das espécies de produção de ácido pseudomónicoA do gênero de bactéria Pseudomonas que consiste na extraçãodo ácido pseudomónico A biossintetizado do fluido de cultura empH acidífero com um hidrocarboneto alifático clorado ou isobutylacetato, seguido pela purificação. A invenção inclui processos depurificação do ácido pseudomónico A isolado, incluindo (a) adistribuição do resíduo de extrato evaporado entre o álcool aquosoe algum hidrocarboneto alifático ou aromático e, em seguida, aextração de água aumentada contendo fase alcoólica aquosa comcloreto metileno, acetato etílico ou isobutyl acetato; (b) extração doextrato com solução de carbonato de hidrogênio de amóniaaquosa, hidróxido de metal alcalino ou hidróxido de amónia e aacidificação do extrato aquoso alcalino e, em seguida, reextraçãocom um hidrocarboneto alifático clorado ou isobutyl acetato; e (c) aconcentração do extrato e a recristalização do ácidopseudomónico A cristalino em uma mistura de isobutyl acetato eéter de petróleo ou acetonitrila ou acetonitrila aquosa.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11844799P | 1999-02-03 | 1999-02-03 | |
| PCT/US2000/002824 WO2000046388A1 (en) | 1999-02-03 | 2000-02-03 | Process for the isolation of pseudomonic acid a from pseudomonic acid complex-containing culture broth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0009178A true BR0009178A (pt) | 2001-11-20 |
Family
ID=22378653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0009178-2A BR0009178A (pt) | 1999-02-03 | 2000-02-03 | Processo para o isolamento de ácidopseudomÈnico a partir de ácido pseudomÈnicocomplexo contendo fluido de cultura |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6245921B1 (pt) |
| EP (1) | EP1147210A4 (pt) |
| JP (1) | JP2002535996A (pt) |
| KR (1) | KR20010112258A (pt) |
| CN (1) | CN1345377A (pt) |
| AU (1) | AU771214B2 (pt) |
| BG (1) | BG105775A (pt) |
| BR (1) | BR0009178A (pt) |
| CA (1) | CA2360840A1 (pt) |
| CZ (1) | CZ20012725A3 (pt) |
| HK (1) | HK1041294A1 (pt) |
| HR (1) | HRP20010570A2 (pt) |
| HU (1) | HUP0105286A3 (pt) |
| IL (1) | IL144678A0 (pt) |
| IS (1) | IS6034A (pt) |
| MX (1) | MXPA01007805A (pt) |
| NO (1) | NO20013790L (pt) |
| PL (1) | PL349153A1 (pt) |
| SK (1) | SK10902001A3 (pt) |
| TR (1) | TR200102232T2 (pt) |
| WO (1) | WO2000046388A1 (pt) |
| YU (1) | YU55501A (pt) |
| ZA (1) | ZA200106057B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200102234T2 (tr) | 1999-02-03 | 2002-10-21 | Biogal Gyogyszergyar Rt. | Psödomonik asit A antibiyotiğinin mikrobiyolojik yöntem ile hazırlanması için işlem |
| US7439045B2 (en) | 2001-06-21 | 2008-10-21 | TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság | pH controlled fermentation process for pseudomonic acid production |
| DE20220885U1 (de) * | 2001-12-28 | 2004-06-24 | BIOGAL Gyógyszergyár Rt. | Kristallines und amorphes Mupirocin-Calcium |
| IL150907A (en) * | 2002-07-25 | 2007-07-04 | Stephan Cherkez | Process for the preparation of stable amorphous calcium pseudomonate |
| DE602005019509D1 (de) | 2004-06-01 | 2010-04-08 | Teva Gyogyszergyar Zartkoeruen | Verfahren für die zubereitung der amorphen form eines medikamentes |
| CN101124221B (zh) * | 2005-02-21 | 2012-05-23 | 克利亚制药股份公司 | 莫匹罗星的提纯方法 |
| GB2441328A (en) * | 2006-08-30 | 2008-03-05 | Alpharma Aps | A method for obtaining mupirocin calcium |
| US8268975B2 (en) | 2009-04-03 | 2012-09-18 | Dow Agrosciences Llc | Demulsification compositions, systems and methods for demulsifying and separating aqueous emulsions |
| CN104370896A (zh) * | 2013-11-29 | 2015-02-25 | 江苏汉邦科技有限公司 | 一种纯化假单孢菌素的方法 |
| CN103820369B (zh) * | 2014-03-07 | 2015-11-18 | 浙江瑞邦药业有限公司 | 一种萤光假单胞菌及其应用 |
| CN109053707B (zh) * | 2018-09-19 | 2021-08-17 | 福建康鸿生物科技有限公司 | 一种莫匹罗星的提纯方法 |
| CN110823649A (zh) * | 2019-10-21 | 2020-02-21 | 河南中烟工业有限责任公司 | 一种卷烟主流烟气中有机酸的收集方法和检测方法 |
| CN116018342A (zh) * | 2020-08-25 | 2023-04-25 | 杭州中美华东制药有限公司 | 一种莫匹罗星的提取方法 |
| TW202231871A (zh) * | 2021-02-07 | 2022-08-16 | 大陸商杭州中美華東製藥有限公司 | 莫匹羅星的發酵方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1395907A (en) | 1971-06-12 | 1975-05-29 | Beecham Group Ltd | Antibiotics |
| JPS5270083A (en) | 1975-12-04 | 1977-06-10 | Yoshitomi Pharmaceut Ind Ltd | Manufacture of an antibiotics, trans-pseudomonic acid |
| CA1103264A (en) * | 1977-09-30 | 1981-06-16 | Norman H. Rogers | Purification of pseudomonic acid |
| CA1115699A (en) | 1978-05-20 | 1982-01-05 | Alan D. Curzons | Lithium pseudomonate and its preparation |
| ZA923242B (en) * | 1991-05-07 | 1993-01-27 | Sankyo Co | Novel anti-bacterial compound |
-
2000
- 2000-02-03 HU HU0105286A patent/HUP0105286A3/hu unknown
- 2000-02-03 YU YU55501A patent/YU55501A/sh unknown
- 2000-02-03 MX MXPA01007805A patent/MXPA01007805A/es unknown
- 2000-02-03 CZ CZ20012725A patent/CZ20012725A3/cs unknown
- 2000-02-03 WO PCT/US2000/002824 patent/WO2000046388A1/en not_active Application Discontinuation
- 2000-02-03 CN CN00805537A patent/CN1345377A/zh active Pending
- 2000-02-03 EP EP00908467A patent/EP1147210A4/en not_active Withdrawn
- 2000-02-03 KR KR1020017009823A patent/KR20010112258A/ko not_active Application Discontinuation
- 2000-02-03 JP JP2000597447A patent/JP2002535996A/ja active Pending
- 2000-02-03 AU AU29802/00A patent/AU771214B2/en not_active Ceased
- 2000-02-03 IL IL14467800A patent/IL144678A0/xx unknown
- 2000-02-03 US US09/497,806 patent/US6245921B1/en not_active Expired - Fee Related
- 2000-02-03 PL PL00349153A patent/PL349153A1/xx not_active Application Discontinuation
- 2000-02-03 TR TR2001/02232T patent/TR200102232T2/xx unknown
- 2000-02-03 SK SK1090-2001A patent/SK10902001A3/sk unknown
- 2000-02-03 CA CA002360840A patent/CA2360840A1/en not_active Abandoned
- 2000-02-03 BR BR0009178-2A patent/BR0009178A/pt not_active IP Right Cessation
-
2001
- 2001-07-24 ZA ZA200106057A patent/ZA200106057B/en unknown
- 2001-07-27 HR HR20010570A patent/HRP20010570A2/hr not_active Application Discontinuation
- 2001-08-01 IS IS6034A patent/IS6034A/is unknown
- 2001-08-02 NO NO20013790A patent/NO20013790L/no not_active Application Discontinuation
- 2001-08-03 BG BG105775A patent/BG105775A/xx active Pending
-
2002
- 2002-04-22 HK HK02103004.6A patent/HK1041294A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1147210A1 (en) | 2001-10-24 |
| NO20013790D0 (no) | 2001-08-02 |
| NO20013790L (no) | 2001-10-02 |
| KR20010112258A (ko) | 2001-12-20 |
| HUP0105286A3 (en) | 2003-03-28 |
| US6245921B1 (en) | 2001-06-12 |
| YU55501A (sh) | 2003-07-07 |
| HRP20010570A2 (en) | 2002-08-31 |
| AU771214B2 (en) | 2004-03-18 |
| BG105775A (en) | 2002-03-29 |
| IS6034A (is) | 2001-08-01 |
| ZA200106057B (en) | 2002-07-24 |
| TR200102232T2 (tr) | 2002-02-21 |
| HUP0105286A2 (hu) | 2002-05-29 |
| MXPA01007805A (es) | 2003-06-04 |
| EP1147210A4 (en) | 2004-06-02 |
| SK10902001A3 (sk) | 2002-04-04 |
| CA2360840A1 (en) | 2000-08-10 |
| CZ20012725A3 (cs) | 2002-03-13 |
| JP2002535996A (ja) | 2002-10-29 |
| HK1041294A1 (zh) | 2002-07-05 |
| AU2980200A (en) | 2000-08-25 |
| PL349153A1 (en) | 2002-07-01 |
| WO2000046388A1 (en) | 2000-08-10 |
| CN1345377A (zh) | 2002-04-17 |
| IL144678A0 (en) | 2002-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008. |