YU55501A - Proces za izolaciju pseudomonične kiseline a iz kompleksa pseudomonične kiseline sadržanog u kulturnom bujonu - Google Patents
Proces za izolaciju pseudomonične kiseline a iz kompleksa pseudomonične kiseline sadržanog u kulturnom bujonuInfo
- Publication number
- YU55501A YU55501A YU55501A YUP55501A YU55501A YU 55501 A YU55501 A YU 55501A YU 55501 A YU55501 A YU 55501A YU P55501 A YUP55501 A YU P55501A YU 55501 A YU55501 A YU 55501A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- pseudomonic acid
- aqueous
- extract
- isobutyl acetate
- culture broth
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Otkriven je proces za izolaciju antibiotika pseudomonicne kiseline A iz kulturnog buljona iz jedne od vrsta bakterijskog roda Pseudomonas koji produkuje pseudomonicnu kiselinu A, koji sadrzi ekstrakciju biosintetizovane pseudomonicne kiseline A iz kulturnog buljona na kiselom pH sa hlorinisanim alifaticnim ugljovodonikom ili izobutil acetatom, pracenu preciscavanjem. Pronalazak ukljucuje procese preciscavanja izolovane pseudomonicne kiseline A, ukljucujuci (a) pomocu distribucije isparenog ostatka ekstrakta izmedju voda-alkohol i nekog alifaticnog ili aromaticnog ugljovodonika, i zatim ekstrakciju povecane voda-alkohol faze koja sadrzi vodu sa metilen hloridom, etil acetatom, ili izobutil acetatom; (b) putem ekstrakcije ekstrakta sa vodenim amonijum hidrogen karbonatom, alkalnim metal hidroksidom ili rastvorom amonijum hidroksida i zakiseljavanjem nastalog alkalnog vodenog ekstrakta, zatim ponovne reekstrakcije sa hlorinisanim alifaticnim ugljovodonikom ili izobutil acetatom; i (c) koncentrisanje ekstrakta i rekristalizaciju kristalne pseudomonicne kiseline A u mesavini izobutil acetata i petroleum etra, ili acetonitrila, ili vodenog acetonitrila.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11844799P | 1999-02-03 | 1999-02-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU55501A true YU55501A (sh) | 2003-07-07 |
Family
ID=22378653
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU55501A YU55501A (sh) | 1999-02-03 | 2000-02-03 | Proces za izolaciju pseudomonične kiseline a iz kompleksa pseudomonične kiseline sadržanog u kulturnom bujonu |
Country Status (23)
Country | Link |
---|---|
US (1) | US6245921B1 (sh) |
EP (1) | EP1147210A4 (sh) |
JP (1) | JP2002535996A (sh) |
KR (1) | KR20010112258A (sh) |
CN (1) | CN1345377A (sh) |
AU (1) | AU771214B2 (sh) |
BG (1) | BG105775A (sh) |
BR (1) | BR0009178A (sh) |
CA (1) | CA2360840A1 (sh) |
CZ (1) | CZ20012725A3 (sh) |
HK (1) | HK1041294A1 (sh) |
HR (1) | HRP20010570A2 (sh) |
HU (1) | HUP0105286A3 (sh) |
IL (1) | IL144678A0 (sh) |
IS (1) | IS6034A (sh) |
MX (1) | MXPA01007805A (sh) |
NO (1) | NO20013790L (sh) |
PL (1) | PL349153A1 (sh) |
SK (1) | SK10902001A3 (sh) |
TR (1) | TR200102232T2 (sh) |
WO (1) | WO2000046388A1 (sh) |
YU (1) | YU55501A (sh) |
ZA (1) | ZA200106057B (sh) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000046389A1 (en) * | 1999-02-03 | 2000-08-10 | Biogal Gyogyszergyar Rt | Process for the preparation of pseudomonic acid a antibiotic by microbiological method |
AU2002345856A1 (en) * | 2001-06-21 | 2003-01-08 | Biogal Gyogyszergyar Rt | Metabolic controlled fermentation process for pseudomonic acid production |
DE20220885U1 (de) * | 2001-12-28 | 2004-06-24 | BIOGAL Gyógyszergyár Rt. | Kristallines und amorphes Mupirocin-Calcium |
IL150907A (en) * | 2002-07-25 | 2007-07-04 | Stephan Cherkez | Process for the preparation of stable amorphous calcium pseudomonate |
WO2005117837A1 (en) * | 2004-06-01 | 2005-12-15 | Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg | Process for preparation of amorphous form of a drug |
US7619102B2 (en) | 2005-02-21 | 2009-11-17 | Axellia Pharmaceuticals Aps | Purification of mupirocin |
GB2441328A (en) * | 2006-08-30 | 2008-03-05 | Alpharma Aps | A method for obtaining mupirocin calcium |
US8268975B2 (en) * | 2009-04-03 | 2012-09-18 | Dow Agrosciences Llc | Demulsification compositions, systems and methods for demulsifying and separating aqueous emulsions |
CN104370896A (zh) * | 2013-11-29 | 2015-02-25 | 江苏汉邦科技有限公司 | 一种纯化假单孢菌素的方法 |
CN103820369B (zh) * | 2014-03-07 | 2015-11-18 | 浙江瑞邦药业有限公司 | 一种萤光假单胞菌及其应用 |
CN109053707B (zh) * | 2018-09-19 | 2021-08-17 | 福建康鸿生物科技有限公司 | 一种莫匹罗星的提纯方法 |
CN110823649A (zh) * | 2019-10-21 | 2020-02-21 | 河南中烟工业有限责任公司 | 一种卷烟主流烟气中有机酸的收集方法和检测方法 |
US20230312540A1 (en) * | 2020-08-25 | 2023-10-05 | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd | Method for extracting mupirocin |
CN116867905A (zh) * | 2021-02-07 | 2023-10-10 | 杭州中美华东制药有限公司 | 一种莫匹罗星的发酵方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1395907A (en) | 1971-06-12 | 1975-05-29 | Beecham Group Ltd | Antibiotics |
JPS5270083A (en) | 1975-12-04 | 1977-06-10 | Yoshitomi Pharmaceut Ind Ltd | Manufacture of an antibiotics, trans-pseudomonic acid |
CA1103264A (en) * | 1977-09-30 | 1981-06-16 | Norman H. Rogers | Purification of pseudomonic acid |
CA1115699A (en) | 1978-05-20 | 1982-01-05 | Alan D. Curzons | Lithium pseudomonate and its preparation |
IS1606B (is) * | 1991-05-07 | 1996-10-18 | Sankyo Company Limited | Aðferð til framleiðslu nýs sýkladrepandi efnasambands Thiomarinol, fengið með ræktun Alteromanas rava SANK 73390 |
-
2000
- 2000-02-03 HU HU0105286A patent/HUP0105286A3/hu unknown
- 2000-02-03 KR KR1020017009823A patent/KR20010112258A/ko not_active Application Discontinuation
- 2000-02-03 SK SK1090-2001A patent/SK10902001A3/sk unknown
- 2000-02-03 BR BR0009178-2A patent/BR0009178A/pt not_active IP Right Cessation
- 2000-02-03 YU YU55501A patent/YU55501A/sh unknown
- 2000-02-03 TR TR2001/02232T patent/TR200102232T2/xx unknown
- 2000-02-03 EP EP00908467A patent/EP1147210A4/en not_active Withdrawn
- 2000-02-03 CA CA002360840A patent/CA2360840A1/en not_active Abandoned
- 2000-02-03 CN CN00805537A patent/CN1345377A/zh active Pending
- 2000-02-03 IL IL14467800A patent/IL144678A0/xx unknown
- 2000-02-03 US US09/497,806 patent/US6245921B1/en not_active Expired - Fee Related
- 2000-02-03 WO PCT/US2000/002824 patent/WO2000046388A1/en not_active Application Discontinuation
- 2000-02-03 MX MXPA01007805A patent/MXPA01007805A/es unknown
- 2000-02-03 CZ CZ20012725A patent/CZ20012725A3/cs unknown
- 2000-02-03 AU AU29802/00A patent/AU771214B2/en not_active Ceased
- 2000-02-03 PL PL00349153A patent/PL349153A1/xx not_active Application Discontinuation
- 2000-02-03 JP JP2000597447A patent/JP2002535996A/ja active Pending
-
2001
- 2001-07-24 ZA ZA200106057A patent/ZA200106057B/en unknown
- 2001-07-27 HR HR20010570A patent/HRP20010570A2/hr not_active Application Discontinuation
- 2001-08-01 IS IS6034A patent/IS6034A/is unknown
- 2001-08-02 NO NO20013790A patent/NO20013790L/no not_active Application Discontinuation
- 2001-08-03 BG BG105775A patent/BG105775A/xx active Pending
-
2002
- 2002-04-22 HK HK02103004.6A patent/HK1041294A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
BR0009178A (pt) | 2001-11-20 |
MXPA01007805A (es) | 2003-06-04 |
ZA200106057B (en) | 2002-07-24 |
US6245921B1 (en) | 2001-06-12 |
AU771214B2 (en) | 2004-03-18 |
EP1147210A1 (en) | 2001-10-24 |
IS6034A (is) | 2001-08-01 |
HRP20010570A2 (en) | 2002-08-31 |
NO20013790D0 (no) | 2001-08-02 |
CN1345377A (zh) | 2002-04-17 |
KR20010112258A (ko) | 2001-12-20 |
BG105775A (en) | 2002-03-29 |
HK1041294A1 (zh) | 2002-07-05 |
IL144678A0 (en) | 2002-06-30 |
EP1147210A4 (en) | 2004-06-02 |
JP2002535996A (ja) | 2002-10-29 |
AU2980200A (en) | 2000-08-25 |
CA2360840A1 (en) | 2000-08-10 |
CZ20012725A3 (cs) | 2002-03-13 |
WO2000046388A1 (en) | 2000-08-10 |
SK10902001A3 (sk) | 2002-04-04 |
NO20013790L (no) | 2001-10-02 |
TR200102232T2 (tr) | 2002-02-21 |
PL349153A1 (en) | 2002-07-01 |
HUP0105286A3 (en) | 2003-03-28 |
HUP0105286A2 (hu) | 2002-05-29 |
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