PT918878E - Processo melhorado para a producao fermentativa de cefalosporina - Google Patents

Processo melhorado para a producao fermentativa de cefalosporina

Info

Publication number
PT918878E
PT918878E PT98925484T PT98925484T PT918878E PT 918878 E PT918878 E PT 918878E PT 98925484 T PT98925484 T PT 98925484T PT 98925484 T PT98925484 T PT 98925484T PT 918878 E PT918878 E PT 918878E
Authority
PT
Portugal
Prior art keywords
organic solvent
extraction
cephalosporin
cephalosporin compound
substituted
Prior art date
Application number
PT98925484T
Other languages
English (en)
Inventor
John Krijgsman
Erik De Vroom
Smeets Jan Willem Hubert
De Braal Henriette Elisab Anna
Fasel Herman Pieter
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of PT918878E publication Critical patent/PT918878E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT98925484T 1997-04-22 1998-04-22 Processo melhorado para a producao fermentativa de cefalosporina PT918878E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97201201 1997-04-22
PCT/EP1998/002459 WO1998048036A1 (en) 1997-04-22 1998-04-22 Improved process for the fermentative production of cephalosporin

Publications (1)

Publication Number Publication Date
PT918878E true PT918878E (pt) 2005-05-31

Family

ID=8228241

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98925484T PT918878E (pt) 1997-04-22 1998-04-22 Processo melhorado para a producao fermentativa de cefalosporina

Country Status (16)

Country Link
US (1) US6319684B1 (pt)
EP (1) EP0918878B1 (pt)
JP (1) JP2000512510A (pt)
CN (1) CN1137271C (pt)
AT (1) ATE288962T1 (pt)
AU (1) AU7759298A (pt)
BR (1) BR9804855A (pt)
DE (1) DE69828940T2 (pt)
ES (1) ES2237840T3 (pt)
PL (1) PL330706A1 (pt)
PT (1) PT918878E (pt)
RO (1) RO120653B1 (pt)
RU (1) RU2203323C2 (pt)
TW (1) TW565612B (pt)
WO (1) WO1998048036A1 (pt)
ZA (1) ZA983383B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2186347T3 (es) * 1998-03-27 2003-05-01 Dsm Nv Nuevo procedimiento de produccion por fermentacion de cefalosporina.
CA2408853C (en) * 2000-05-13 2012-01-10 Smithkline Beecham P.L.C. Process
JP2002316991A (ja) * 2001-04-18 2002-10-31 Otsuka Chem Co Ltd ペニシリン及びセファロスポリン化合物
CN103108879B (zh) 2010-09-07 2016-08-17 中化帝斯曼制药有限公司荷兰公司 用于生产头孢菌素类的方法
EP2681224B1 (en) * 2011-03-03 2016-06-22 DSM Sinochem Pharmaceuticals Netherlands B.V. Degradation of penicillin compounds
CN111875621A (zh) * 2020-08-26 2020-11-03 山东鲁抗医药股份有限公司 一种注射用头孢菌素盐的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1299883A (fr) * 1961-09-06 1962-07-27 Pfizer & Co C Perfectionnements apportés aux procédés pour séparer des amino-acides amphotères de leurs solutions aqueuses
GB1473100A (pt) * 1973-05-10 1977-05-11
DE3729338A1 (de) * 1987-09-02 1989-03-23 Biotechnolog Forschung Gmbh Verfahren zur abtrennung von penicillin g aus einem fermentationsmedium durch extraktion
US5318896A (en) 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정
DE69434023D1 (de) 1993-07-30 2004-10-28 Dsm Ip Assets Bv Verfahren zur effizienten Herstellung von 7-ADCA via 2-(carboxyethylthio)acetyl-7-ADCA und 3-(carboxymethylthio)propionyl-7-ADCA
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G

Also Published As

Publication number Publication date
BR9804855A (pt) 1999-08-24
JP2000512510A (ja) 2000-09-26
CN1224470A (zh) 1999-07-28
RO120653B1 (ro) 2006-05-30
RU2203323C2 (ru) 2003-04-27
US6319684B1 (en) 2001-11-20
CN1137271C (zh) 2004-02-04
EP0918878B1 (en) 2005-02-09
EP0918878A1 (en) 1999-06-02
ES2237840T3 (es) 2005-08-01
DE69828940D1 (de) 2005-03-17
ATE288962T1 (de) 2005-02-15
PL330706A1 (en) 1999-05-24
WO1998048036A1 (en) 1998-10-29
ZA983383B (en) 1998-10-27
AU7759298A (en) 1998-11-13
TW565612B (en) 2003-12-11
DE69828940T2 (de) 2005-12-29

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