ES2186347T3 - Nuevo procedimiento de produccion por fermentacion de cefalosporina. - Google Patents

Nuevo procedimiento de produccion por fermentacion de cefalosporina.

Info

Publication number
ES2186347T3
ES2186347T3 ES99915731T ES99915731T ES2186347T3 ES 2186347 T3 ES2186347 T3 ES 2186347T3 ES 99915731 T ES99915731 T ES 99915731T ES 99915731 T ES99915731 T ES 99915731T ES 2186347 T3 ES2186347 T3 ES 2186347T3
Authority
ES
Spain
Prior art keywords
mixture
complex mixture
cephalosporine
fermentation
adipyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99915731T
Other languages
English (en)
Inventor
Ilco Adrianus Lambertu Boogers
De Sandt Emilius Johannes Van
Dick Schipper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Application granted granted Critical
Publication of ES2186347T3 publication Critical patent/ES2186347T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/08—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin disubstituted in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/183—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing an indolo[4,3-F,G]quinoleine nucleus, e.g. compound containing the lysergic acid nucleus as well as the dimeric ergot nucleus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin

Abstract

Un método para la recuperación de un compuesto de ácido cefalosporánico N-sustituido de fórmula general (I):**Fórmula** en la que ¿ R0 es hidrógeno o alcoxilo C1_3; ¿ Y es CH2, oxígeno, azufre, o una forma oxidada del azufre; ¿ R1 es cualquiera de los grupos seleccionados del grupo consistente en - hidrógeno, hidroxilo, - halógeno, - alquilo saturado o insaturado, de cadena lineal o ramificada (1-5 átomos de carbono; reemplazados opcionalmente por uno o más heteroátomos), sustituido opcionalmente con hidroxilo, halógeno, arilo, alcoxilo (1-3 átomos de carbono), o acilo; - alcoxilo (1-3 átomos de carbono; reemplazados opcionalmente por uno o más heteroátomos), sustituido opcionalmente con hidroxilo o halógeno; o - cicloalquilo (3-8 átomos de carbono) sustituido opcionalmente con hidroxilo, halógeno, amino, arilo; - heteroarilo; y ¿ R2 se selecciona del grupo consistente en adipil(1, 4-dicarboxibutano), succinilo, glutarilo, adipilo, pimelilo, suberilo, 2-(carboxietiltio)acetilo, 3-(carboxietiltio)pro- pionilo, ácidos dicarboxilícos de alquilo superior saturado y alquilo superior insaturado, de una mezcla compleja que comprende además del compuesto de la fórmula general ácido 6-aminopenicilánico (6-APA) y opcionalmente uno o más compuestos /3-lactama N-sustituidos, que comprende las etapas de: (a) acidificar la mezcla compleja hasta un pH menor de 6, 5 y mantener la mezcla por debajo de dicho pH a una temperatura entre 50°C y 130°C; y/o (b) poner en contacto la mezcla compleja con una fuente de dióxido de carbono; y (c) someter la mezcla obtenida después de las etapas (a) y/o (b) a cromatografía para recuperar el compuesto de ácido cefalosporánico de fórmula (I).
ES99915731T 1998-03-27 1999-03-26 Nuevo procedimiento de produccion por fermentacion de cefalosporina. Expired - Lifetime ES2186347T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98201011 1998-03-27

Publications (1)

Publication Number Publication Date
ES2186347T3 true ES2186347T3 (es) 2003-05-01

Family

ID=8233541

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99915731T Expired - Lifetime ES2186347T3 (es) 1998-03-27 1999-03-26 Nuevo procedimiento de produccion por fermentacion de cefalosporina.

Country Status (17)

Country Link
US (2) US6552185B1 (es)
EP (1) EP1066294B1 (es)
JP (1) JP2002509933A (es)
KR (1) KR100594774B1 (es)
CN (1) CN1138781C (es)
AT (1) ATE226954T1 (es)
AU (1) AU3419399A (es)
BR (1) BR9909108A (es)
DE (1) DE69903719T2 (es)
ES (1) ES2186347T3 (es)
ID (1) ID26888A (es)
PL (1) PL343099A1 (es)
PT (1) PT1066294E (es)
RU (1) RU2219182C2 (es)
SI (1) SI1066294T1 (es)
WO (1) WO1999050271A1 (es)
ZA (1) ZA200004801B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE226954T1 (de) * 1998-03-27 2002-11-15 Dsm Nv Verfahren zur fermentativen herstellung von cephalosporin
KR100494825B1 (ko) * 1999-09-30 2005-06-14 오쯔까 가가꾸 가부시키가이샤 3-세펨 유도체 결정 및 그 제조 방법
JP2002316991A (ja) * 2001-04-18 2002-10-31 Otsuka Chem Co Ltd ペニシリン及びセファロスポリン化合物
CN1912130B (zh) * 2005-08-08 2011-06-15 百瑞全球有限公司 一种用于制备7-氨基头孢霉烷酸的两步酶法
WO2012032040A1 (en) 2010-09-07 2012-03-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the production of cephalosporins
EP3666074A1 (en) * 2018-12-16 2020-06-17 Sandoz GmbH Adjuvant composition, method of producing the adjuvant composi-tion and uses thereof
CN112625053B (zh) * 2020-12-30 2022-08-09 伊犁川宁生物技术股份有限公司 一种具有低含量最大未知单杂的7-aca及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE465649A (es) * 1944-06-19
GB810196A (en) * 1955-02-02 1959-03-11 Nat Res Dev Cephalosporin c
GB1272769A (en) * 1968-08-02 1972-05-03 Glaxo Lab Ltd Improvements in or relating to cephalosporin derivatives
FR2404642A1 (fr) * 1977-09-29 1979-04-27 Roussel Uclaf Nouveau derive de la cephalosporine c, procede de preparation et application du nouveau produit a la preparation de l'acide 7-amino cephalosporanique
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
SK280569B6 (sk) 1991-10-15 2000-03-13 Gist-Brocades B.V. Biologický spôsob výroby kyseliny7-aminodeacetylce
SK282624B6 (sk) 1993-07-30 2002-10-08 Dsm N. V. Spôsob výroby a izolácie 7-aminodesacetoxycefalosporánovej kyseliny
BE1009070A3 (nl) * 1995-02-02 1996-11-05 Dsm Nv Werkwijze voor de winning van een beta-lactam antibioticum.
AU3661597A (en) * 1996-07-29 1998-02-20 Bristol-Myers Squibb Company Solvent extraction of 3-hydroxymethylcephalosporins
BE1010651A3 (nl) * 1996-09-27 1998-11-03 Dsm Nv Werkwijze voor het zuiveren van cefalexine.
WO1998048036A1 (en) 1997-04-22 1998-10-29 Gist-Brocades B.V. Improved process for the fermentative production of cephalosporin
ATE226954T1 (de) * 1998-03-27 2002-11-15 Dsm Nv Verfahren zur fermentativen herstellung von cephalosporin

Also Published As

Publication number Publication date
RU2219182C2 (ru) 2003-12-20
WO1999050271A1 (en) 1999-10-07
BR9909108A (pt) 2000-12-12
EP1066294A1 (en) 2001-01-10
US6552185B1 (en) 2003-04-22
ATE226954T1 (de) 2002-11-15
KR100594774B1 (ko) 2006-07-03
DE69903719D1 (de) 2002-12-05
PL343099A1 (en) 2001-07-30
JP2002509933A (ja) 2002-04-02
PT1066294E (pt) 2003-03-31
SI1066294T1 (en) 2003-04-30
US20030139595A1 (en) 2003-07-24
KR20010034700A (ko) 2001-04-25
CN1295575A (zh) 2001-05-16
AU3419399A (en) 1999-10-18
US6803460B2 (en) 2004-10-12
ID26888A (id) 2001-02-15
CN1138781C (zh) 2004-02-18
DE69903719T2 (de) 2003-09-18
ZA200004801B (en) 2001-07-25
EP1066294B1 (en) 2002-10-30

Similar Documents

Publication Publication Date Title
DE60311599D1 (de) Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten
ES2186347T3 (es) Nuevo procedimiento de produccion por fermentacion de cefalosporina.
DE3685371D1 (de) Verfahren zur herstellung eines amids durch verwendung eines mikroorganismus.
DE58900982D1 (de) Verfahren zur herstellung von alpha, beta -ungesaettigten ketonen.
ATE35826T1 (de) Verfahren zur herstellung von l-alphaaminos|uren.
DE69828940D1 (de) Verbessertes verfahren zur fermentativen herstellung von cephalosporin
LV10504A (lv) Mikrobiologiskais panemiens slapekli saturoso heterociklisko karbonskabju hidroksilesanai
JP2002509933A5 (es)
RS49832B (sr) Postupak za dobijanje aminskih derivata alkiloksifuranona, dobijanje jedinjenja i upotreba ovih jedinjenja
ATE144794T1 (de) Verfahren zur enzymatischen herstellung von 7- amino-cephalosporansäure
KR880006250A (ko) 3-치환된 세팔로스포린의 제조 방법
ATE183778T1 (de) Verfahren zur herstellung von cephalosporinen
NZ508179A (en) Process for preparing crystalline salts of amoxycillin
ATE245136T1 (de) Verfahren zum herstellen eines tert-alkylesters einer carbonsäure
ATE231125T1 (de) Einfaches verfahren zur herstellung von hochwertigem captropril
KR870003122A (ko) 3-비닐 세팔로스포린 유도체의 제조방법
KR930021796A (ko) 미생물에 의한 말로닐-7-아미노세팔로스포린산 유도체의 제조방법
MXPA02005084A (es) Procedimiento para fabricar tienopirimidinas.
ATE66961T1 (de) Verfahren zur herstellung von penemen.
JPS55138396A (en) Production of cephalosporin analogs
GB1467102A (en) Process for the production of carboxylic compounds
MY105302A (en) Process for dehydrating corticosteroid intermediates.
ATE516361T1 (de) Verfahren zur herstellung eines carbonsäure- isomers
TH2899EX (th) กรรมวิธีในการเตรียมอนุพันธ์ของกรดควิโนลีนคาร์บอกซิลิค