ATE226954T1 - Verfahren zur fermentativen herstellung von cephalosporin - Google Patents
Verfahren zur fermentativen herstellung von cephalosporinInfo
- Publication number
- ATE226954T1 ATE226954T1 AT99915731T AT99915731T ATE226954T1 AT E226954 T1 ATE226954 T1 AT E226954T1 AT 99915731 T AT99915731 T AT 99915731T AT 99915731 T AT99915731 T AT 99915731T AT E226954 T1 ATE226954 T1 AT E226954T1
- Authority
- AT
- Austria
- Prior art keywords
- mixture
- complex mixture
- adipyl
- general formula
- steps
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 238000012262 fermentative production Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 5
- -1 cephalosporanic acid compound Chemical class 0.000 abstract 4
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 2
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
- RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical class OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/08—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin disubstituted in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C12P17/183—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing an indolo[4,3-F,G]quinoleine nucleus, e.g. compound containing the lysergic acid nucleus as well as the dimeric ergot nucleus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98201011 | 1998-03-27 | ||
| PCT/EP1999/002247 WO1999050271A1 (en) | 1998-03-27 | 1999-03-26 | Novel process for the fermentative production of cephalosporin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE226954T1 true ATE226954T1 (de) | 2002-11-15 |
Family
ID=8233541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99915731T ATE226954T1 (de) | 1998-03-27 | 1999-03-26 | Verfahren zur fermentativen herstellung von cephalosporin |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6552185B1 (de) |
| EP (1) | EP1066294B1 (de) |
| JP (1) | JP2002509933A (de) |
| KR (1) | KR100594774B1 (de) |
| CN (1) | CN1138781C (de) |
| AT (1) | ATE226954T1 (de) |
| AU (1) | AU3419399A (de) |
| BR (1) | BR9909108A (de) |
| DE (1) | DE69903719T2 (de) |
| ES (1) | ES2186347T3 (de) |
| ID (1) | ID26888A (de) |
| PL (1) | PL343099A1 (de) |
| PT (1) | PT1066294E (de) |
| RU (1) | RU2219182C2 (de) |
| SI (1) | SI1066294T1 (de) |
| WO (1) | WO1999050271A1 (de) |
| ZA (1) | ZA200004801B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1138781C (zh) * | 1998-03-27 | 2004-02-18 | Dsm公司 | 从发酵液中回收头孢菌素类化合物的方法 |
| WO2001023393A1 (en) * | 1999-09-30 | 2001-04-05 | Otsuka Kagaku Kabushiki Kaisha | 3-cephem derivative crystal and method for preparing the same |
| JP2002316991A (ja) * | 2001-04-18 | 2002-10-31 | Otsuka Chem Co Ltd | ペニシリン及びセファロスポリン化合物 |
| CN1912130B (zh) * | 2005-08-08 | 2011-06-15 | 百瑞全球有限公司 | 一种用于制备7-氨基头孢霉烷酸的两步酶法 |
| WO2012032040A1 (en) | 2010-09-07 | 2012-03-15 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Process for the production of cephalosporins |
| EP3666074A1 (de) * | 2018-12-16 | 2020-06-17 | Sandoz GmbH | Adjuvanszusammensetzung, verfahren zur herstellung der adjuvanszusammensetzung und deren verwendung |
| CN112625053B (zh) * | 2020-12-30 | 2022-08-09 | 伊犁川宁生物技术股份有限公司 | 一种具有低含量最大未知单杂的7-aca及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE465649A (de) * | 1944-06-19 | |||
| GB810196A (en) * | 1955-02-02 | 1959-03-11 | Nat Res Dev | Cephalosporin c |
| GB1272769A (en) * | 1968-08-02 | 1972-05-03 | Glaxo Lab Ltd | Improvements in or relating to cephalosporin derivatives |
| FR2404642A1 (fr) * | 1977-09-29 | 1979-04-27 | Roussel Uclaf | Nouveau derive de la cephalosporine c, procede de preparation et application du nouveau produit a la preparation de l'acide 7-amino cephalosporanique |
| DE4127648C1 (de) * | 1991-08-21 | 1993-01-14 | Hoechst Ag, 6230 Frankfurt, De | |
| US5318896A (en) * | 1991-09-11 | 1994-06-07 | Merck & Co., Inc. | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) |
| KR100227711B1 (ko) | 1991-10-15 | 1999-12-01 | 한스 발터 라벤 | 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정 |
| DE69434023D1 (de) | 1993-07-30 | 2004-10-28 | Dsm Ip Assets Bv | Verfahren zur effizienten Herstellung von 7-ADCA via 2-(carboxyethylthio)acetyl-7-ADCA und 3-(carboxymethylthio)propionyl-7-ADCA |
| BE1009070A3 (nl) * | 1995-02-02 | 1996-11-05 | Dsm Nv | Werkwijze voor de winning van een beta-lactam antibioticum. |
| WO1998004565A1 (en) * | 1996-07-29 | 1998-02-05 | Bristol-Myers Squibb Company | Solvent extraction of 3-hydroxymethylcephalosporins |
| BE1010651A3 (nl) * | 1996-09-27 | 1998-11-03 | Dsm Nv | Werkwijze voor het zuiveren van cefalexine. |
| ZA983383B (en) * | 1997-04-22 | 1998-10-27 | Gist Brocades Bv | Process for the fermentative production of cephalosporin |
| CN1138781C (zh) * | 1998-03-27 | 2004-02-18 | Dsm公司 | 从发酵液中回收头孢菌素类化合物的方法 |
-
1999
- 1999-03-26 CN CNB998045500A patent/CN1138781C/zh not_active Expired - Lifetime
- 1999-03-26 WO PCT/EP1999/002247 patent/WO1999050271A1/en not_active Ceased
- 1999-03-26 KR KR1020007010705A patent/KR100594774B1/ko not_active Expired - Fee Related
- 1999-03-26 EP EP99915731A patent/EP1066294B1/de not_active Expired - Lifetime
- 1999-03-26 BR BR9909108-9A patent/BR9909108A/pt not_active Application Discontinuation
- 1999-03-26 ID IDW20001865A patent/ID26888A/id unknown
- 1999-03-26 AU AU34193/99A patent/AU3419399A/en not_active Abandoned
- 1999-03-26 PT PT99915731T patent/PT1066294E/pt unknown
- 1999-03-26 JP JP2000541174A patent/JP2002509933A/ja not_active Withdrawn
- 1999-03-26 ES ES99915731T patent/ES2186347T3/es not_active Expired - Lifetime
- 1999-03-26 PL PL99343099A patent/PL343099A1/xx not_active Application Discontinuation
- 1999-03-26 RU RU2000127023/04A patent/RU2219182C2/ru not_active IP Right Cessation
- 1999-03-26 SI SI9930176T patent/SI1066294T1/xx unknown
- 1999-03-26 AT AT99915731T patent/ATE226954T1/de not_active IP Right Cessation
- 1999-03-26 DE DE69903719T patent/DE69903719T2/de not_active Expired - Fee Related
- 1999-03-27 US US09/647,056 patent/US6552185B1/en not_active Expired - Fee Related
-
2000
- 2000-09-11 ZA ZA200004801A patent/ZA200004801B/xx unknown
-
2002
- 2002-09-24 US US10/254,622 patent/US6803460B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL343099A1 (en) | 2001-07-30 |
| EP1066294A1 (de) | 2001-01-10 |
| DE69903719T2 (de) | 2003-09-18 |
| BR9909108A (pt) | 2000-12-12 |
| US6803460B2 (en) | 2004-10-12 |
| ZA200004801B (en) | 2001-07-25 |
| CN1138781C (zh) | 2004-02-18 |
| CN1295575A (zh) | 2001-05-16 |
| AU3419399A (en) | 1999-10-18 |
| US6552185B1 (en) | 2003-04-22 |
| SI1066294T1 (en) | 2003-04-30 |
| US20030139595A1 (en) | 2003-07-24 |
| JP2002509933A (ja) | 2002-04-02 |
| KR100594774B1 (ko) | 2006-07-03 |
| WO1999050271A1 (en) | 1999-10-07 |
| ID26888A (id) | 2001-02-15 |
| DE69903719D1 (de) | 2002-12-05 |
| KR20010034700A (ko) | 2001-04-25 |
| RU2219182C2 (ru) | 2003-12-20 |
| EP1066294B1 (de) | 2002-10-30 |
| PT1066294E (pt) | 2003-03-31 |
| ES2186347T3 (es) | 2003-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1066294 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |