BR9812482A - Processo para recuperação de um antibiótico de beta-lactama - Google Patents
Processo para recuperação de um antibiótico de beta-lactamaInfo
- Publication number
- BR9812482A BR9812482A BR9812482-0A BR9812482A BR9812482A BR 9812482 A BR9812482 A BR 9812482A BR 9812482 A BR9812482 A BR 9812482A BR 9812482 A BR9812482 A BR 9812482A
- Authority
- BR
- Brazil
- Prior art keywords
- lactam
- antibiotic
- solid
- lactam antibiotic
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/18—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Patente de Invenção: <B>"PROCESSO PARA RECUPERAçãO DE UM ANTI-BIóTICO DE BETA-LACTAMA"<D>. A presente invenção refere-se a um Processo para recuperação de um antibiótico de ß-lactama de uma mistura que contém o antibiótico de ß-lactama e D-fenil glicina (FG) em solução, com a mistura sendo trazida para um pH entre 3 e 8, a uma concentração tal que a FG permanece em solução, o antibiótico sólido de ß-lactama obtido sendo recuperado e o líquido restante sendo submetido a uma etapa de concentração, em que se desenvolve uma pasta fluida com o antibiótico sólido de ß-lactama e a FG sólida, a pasta fluida sendo trazida para um pH em que o antibiótico de ß-lactama se dissolve, a FG sendo separada como um sólido e o antibiótico de ß-lactama presente no licor mãe sendo pelo menos parcialmente utilizado. Preferencialmente, o uso é feito a partir de uma mistura inicial, contendo substancialmente o antibiótico de ß-lactama e FG, originários de uma reação de acilação enzimática, em que o núcleo correspondente de ß-lactama, em particular o ácido 6-aminopenicilânico, o ácido 7-aminodesacetoxicefalosporânico e o ácido 7-amino-3-cloro-cef-3-em-4-carboxílico, são acilados com um derivado de D-fenil glicina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1007077A NL1007077C2 (nl) | 1997-09-19 | 1997-09-19 | Werkwijze voor de winning van een ß-lactam antibioticum. |
| PCT/NL1998/000538 WO1999015531A1 (en) | 1997-09-19 | 1998-09-18 | PROCEDE FOR RECOVERY OF A β-LACTAM ANTIBIOTIC |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9812482A true BR9812482A (pt) | 2000-09-19 |
Family
ID=19765707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9812482-0A BR9812482A (pt) | 1997-09-19 | 1998-09-18 | Processo para recuperação de um antibiótico de beta-lactama |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1017698A1 (pt) |
| KR (1) | KR20010024028A (pt) |
| CN (1) | CN1279685A (pt) |
| AU (1) | AU9189798A (pt) |
| BR (1) | BR9812482A (pt) |
| IN (1) | IN188409B (pt) |
| NL (1) | NL1007077C2 (pt) |
| TR (1) | TR200000880T2 (pt) |
| WO (1) | WO1999015531A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1006266C2 (nl) | 1997-06-10 | 1998-12-14 | Chemferm Vof | Werkwijze voor de bereiding van ampicilline. |
| CN102851332A (zh) * | 2012-09-07 | 2013-01-02 | 石药集团中诺药业（石家庄）有限公司 | 一种酶法氨苄西林母液中d（-）苯甘氨酸的回收方法 |
| CN103805671B (zh) * | 2013-11-11 | 2015-08-26 | 华北制药河北华民药业有限责任公司 | 一种制备头孢氨苄的方法 |
| CN106317076B (zh) * | 2016-07-29 | 2018-08-24 | 华北制药河北华民药业有限责任公司 | 一种7-adca母液回收的方法 |
| CN106220646B (zh) * | 2016-07-29 | 2018-08-24 | 华北制药河北华民药业有限责任公司 | 一种酶法合成头孢氨苄母液的循环利用的方法 |
| CN106526106A (zh) * | 2016-12-07 | 2017-03-22 | 百奥森（江苏）食品安全科技有限公司 | 一种乳品中β‑内酰胺的检测方法 |
| CN108084206B (zh) * | 2018-02-09 | 2019-04-26 | 国药集团威奇达药业有限公司 | 从酶法合成氨苄西林母液中回收氨苄西林的方法 |
| CN111269076A (zh) * | 2020-03-12 | 2020-06-12 | 山东钧睿科技服务有限公司 | 一种酶法合成β-内酰胺类抗生素离心母液回收处理工艺 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034522A (en) * | 1988-08-02 | 1991-07-23 | Biocraft Laboratories, Inc. | Method for the production of 3-methyl cephem derivatives |
| BE1007296A3 (nl) * | 1993-07-19 | 1995-05-09 | Dsm Nv | Werkwijze voor de bereiding van een beta-lactamderivaat. |
| ATE204580T1 (de) * | 1995-02-02 | 2001-09-15 | Dsm Nv | Verfahren zur gewinnung von cephalexin |
| BE1009264A3 (nl) * | 1995-03-31 | 1997-01-07 | Dsm Nv | Werkwijze voor de winning van ampicilline. |
| DE69626842D1 (de) * | 1995-12-08 | 2003-04-24 | Dsm Nv | Verfahren zur herstellung eines anitibiotkums |
| NL1002818C2 (nl) * | 1996-04-09 | 1997-10-15 | Chemferm Vof | Werkwijze voor de bereiding van beta-lactam antibiotica. |
-
1997
- 1997-09-19 NL NL1007077A patent/NL1007077C2/nl not_active IP Right Cessation
-
1998
- 1998-09-08 IN IN2016MA1998 patent/IN188409B/en unknown
- 1998-09-18 WO PCT/NL1998/000538 patent/WO1999015531A1/en not_active Application Discontinuation
- 1998-09-18 TR TR2000/00880T patent/TR200000880T2/xx unknown
- 1998-09-18 CN CN98811310A patent/CN1279685A/zh active Pending
- 1998-09-18 KR KR1020007002763A patent/KR20010024028A/ko not_active Application Discontinuation
- 1998-09-18 EP EP98944337A patent/EP1017698A1/en not_active Withdrawn
- 1998-09-18 BR BR9812482-0A patent/BR9812482A/pt not_active IP Right Cessation
- 1998-09-18 AU AU91897/98A patent/AU9189798A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU9189798A (en) | 1999-04-12 |
| IN188409B (pt) | 2002-09-21 |
| TR200000880T2 (tr) | 2000-11-21 |
| NL1007077C2 (nl) | 1999-03-22 |
| WO1999015531A1 (en) | 1999-04-01 |
| EP1017698A1 (en) | 2000-07-12 |
| CN1279685A (zh) | 2001-01-10 |
| KR20010024028A (ko) | 2001-03-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5O,6O,7O,8O E 9O ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007. |