DE69626842D1 - Verfahren zur herstellung eines anitibiotkums - Google Patents

Verfahren zur herstellung eines anitibiotkums

Info

Publication number
DE69626842D1
DE69626842D1 DE69626842T DE69626842T DE69626842D1 DE 69626842 D1 DE69626842 D1 DE 69626842D1 DE 69626842 T DE69626842 T DE 69626842T DE 69626842 T DE69626842 T DE 69626842T DE 69626842 D1 DE69626842 D1 DE 69626842D1
Authority
DE
Germany
Prior art keywords
beta
antibiotic
lactam core
anitibiot
seal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69626842T
Other languages
English (en)
Inventor
Hubertus Boesten
Den Tweel Johannes Van
Marinus Dekkers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Application granted granted Critical
Publication of DE69626842D1 publication Critical patent/DE69626842D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE69626842T 1995-12-08 1996-12-06 Verfahren zur herstellung eines anitibiotkums Expired - Lifetime DE69626842D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE9501015 1995-12-08
PCT/NL1996/000479 WO1997022610A1 (en) 1995-12-08 1996-12-06 Process for the preparation of an antibiotic

Publications (1)

Publication Number Publication Date
DE69626842D1 true DE69626842D1 (de) 2003-04-24

Family

ID=3889338

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69626842T Expired - Lifetime DE69626842D1 (de) 1995-12-08 1996-12-06 Verfahren zur herstellung eines anitibiotkums

Country Status (10)

Country Link
US (1) US6503727B1 (de)
EP (1) EP0865443B1 (de)
KR (1) KR100455252B1 (de)
CN (1) CN1107070C (de)
AT (1) ATE234846T1 (de)
AU (1) AU7711496A (de)
DE (1) DE69626842D1 (de)
ES (1) ES2195024T3 (de)
PL (1) PL327134A1 (de)
WO (1) WO1997022610A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000382A1 (fr) 1996-07-02 1998-01-08 Toray Industries, Inc. Procedes de preparation de cetones optiquement actives
WO1998048038A1 (en) * 1997-04-22 1998-10-29 Gist-Brocades B.V. A METHOD FOR PREPARING A β-LACTAM ANTIBIOTIC
NL1007076C2 (nl) * 1997-09-19 1999-03-22 Dsm Nv Werkwijze voor de winning van een ß-lactam antibioticum.
NL1007077C2 (nl) * 1997-09-19 1999-03-22 Dsm Nv Werkwijze voor de winning van een ß-lactam antibioticum.
NL1007302C2 (nl) * 1997-10-17 1999-04-20 Dsm Nv Werkwijze voor de bereiding van een ß-lactam antibioticum.
NL1010506C2 (nl) * 1998-11-06 2000-05-09 Dsm Nv Werkwijze voor de bereiding van bêta-lactam antibiotica.
BRPI0711924B1 (pt) * 2006-05-19 2023-11-28 Centrient Pharmaceuticals Netherlands B.V. Processo para a preparação de cefadroxil monoidratado em forma de cristal
CN102392060B (zh) * 2011-09-16 2013-07-31 石药集团中润制药(内蒙古)有限公司 一种利用纳滤回收酶法阿莫西林母液中有效成份的方法
CN103193800B (zh) * 2013-04-08 2016-03-02 中国医药集团总公司四川抗菌素工业研究所 一种从头孢克洛酶促反应液中分离纯化各组分的方法
CN103805672B (zh) * 2014-02-25 2016-05-25 华北制药集团先泰药业有限公司 一种酶法制备氨苄西林的工艺
CN104628587B (zh) * 2015-02-12 2016-06-22 艾美科健（中国）生物医药有限公司 一种回收阿莫西林生产废液中d-对羟基苯甘氨酸的方法
CN105294734B (zh) * 2015-10-16 2018-02-13 华北制药河北华民药业有限责任公司 一种制备头孢尼西二苄基乙二胺盐的方法
CN105603037B (zh) * 2015-12-24 2020-07-31 天津大学 一种酶催化酰化制备头孢菌素的方法
CN105567777A (zh) * 2016-03-07 2016-05-11 内蒙古常盛制药有限公司 一种循环利用阿莫西林母液的方法
CN111269076A (zh) * 2020-03-12 2020-06-12 山东钧睿科技服务有限公司 一种酶法合成β-内酰胺类抗生素离心母液回收处理工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003896A (en) * 1974-12-17 1977-01-18 Novo Industri A/S Method of preparing a sparingly soluble complex of cephalexin
JPS5645196A (en) * 1979-09-19 1981-04-24 Shionogi & Co Ltd Enzymatic synthesis of beta-lactam antibacterial agent
ATE317912T1 (de) * 1990-07-04 2006-03-15 Dsm Ip Assets Bv Verfahren zur herstellung von beta-lactamen
DE618979T1 (de) * 1991-12-19 1995-05-18 Novo Nordisk As Verbesserte methode zur herstellung von bestimmten -g(b)-lactam-antibiotika.
JPH11503408A (ja) * 1995-02-02 1999-03-26 ケムファーム ブイ．オー．エフ． セファレキシンの回収方法

Also Published As

Publication number Publication date
ES2195024T3 (es) 2003-12-01
AU7711496A (en) 1997-07-14
KR100455252B1 (ko) 2005-01-15
CN1207742A (zh) 1999-02-10
EP0865443B1 (de) 2003-03-19
PL327134A1 (en) 1998-11-23
ATE234846T1 (de) 2003-04-15
KR20000064370A (ko) 2000-11-06
WO1997022610A1 (en) 1997-06-26
US6503727B1 (en) 2003-01-07
CN1107070C (zh) 2003-04-30
EP0865443A1 (de) 1998-09-23

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Legal Events

Date Code Title Description
8332 No legal effect for de