DE69622193D1 - Verfahren zur winnung von ampicillin - Google Patents

Verfahren zur winnung von ampicillin

Info

Publication number
DE69622193D1
DE69622193D1 DE69622193T DE69622193T DE69622193D1 DE 69622193 D1 DE69622193 D1 DE 69622193D1 DE 69622193 T DE69622193 T DE 69622193T DE 69622193 T DE69622193 T DE 69622193T DE 69622193 D1 DE69622193 D1 DE 69622193D1
Authority
DE
Germany
Prior art keywords
ampicillin
apa
recovered
mixture
winning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69622193T
Other languages
English (en)
Other versions
DE69622193T2 (de
Inventor
Hubertus Boesten
Monro Moody
Cornelis Roos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Application granted granted Critical
Publication of DE69622193D1 publication Critical patent/DE69622193D1/de
Publication of DE69622193T2 publication Critical patent/DE69622193T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacturing Of Electric Cables (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Ticket-Dispensing Machines (AREA)
  • Bipolar Transistors (AREA)
DE69622193T 1995-03-31 1996-03-25 Verfahren zur winnung von ampicillin Expired - Fee Related DE69622193T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE9500291A BE1009264A3 (nl) 1995-03-31 1995-03-31 Werkwijze voor de winning van ampicilline.
PCT/NL1996/000128 WO1996030376A1 (en) 1995-03-31 1996-03-25 Process for the recovery of ampicillin

Publications (2)

Publication Number Publication Date
DE69622193D1 true DE69622193D1 (de) 2002-08-08
DE69622193T2 DE69622193T2 (de) 2003-03-20

Family

ID=3888891

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69622193T Expired - Fee Related DE69622193T2 (de) 1995-03-31 1996-03-25 Verfahren zur winnung von ampicillin

Country Status (13)

Country Link
EP (1) EP0869960B1 (de)
JP (1) JPH11502832A (de)
KR (1) KR100442040B1 (de)
CN (1) CN1103777C (de)
AT (1) ATE220069T1 (de)
AU (1) AU4958296A (de)
BE (1) BE1009264A3 (de)
CZ (1) CZ307497A3 (de)
DE (1) DE69622193T2 (de)
ES (1) ES2179180T3 (de)
IN (1) IN183010B (de)
MX (1) MX9707550A (de)
WO (1) WO1996030376A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1006266C2 (nl) * 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
NL1007076C2 (nl) * 1997-09-19 1999-03-22 Dsm Nv Werkwijze voor de winning van een ß-lactam antibioticum.
NL1007077C2 (nl) * 1997-09-19 1999-03-22 Dsm Nv Werkwijze voor de winning van een ß-lactam antibioticum.
PE20000879A1 (es) * 1998-04-29 2000-09-23 Dsm Nv METODO PARA CRISTALIZAR UN ANTIBIOTICO ß-LACTAMICO

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1178434B (de) * 1962-09-04 1964-09-24 Bayer Ag Verfahren zur Trennung von 6-Aminopenicillan-saeure und ª‡-Aminobenzylpenicillin
FR2188608A5 (en) * 1972-06-14 1974-01-18 Aries Robert Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids
US3980637A (en) * 1975-03-17 1976-09-14 Bristol-Myers Company Production of amoxicillin
US4354971A (en) * 1981-06-22 1982-10-19 Eli Lilly And Company Non-extractive penicillin V recovery process
BE1007296A3 (nl) * 1993-07-19 1995-05-09 Dsm Nv Werkwijze voor de bereiding van een beta-lactamderivaat.

Also Published As

Publication number Publication date
KR100442040B1 (ko) 2005-08-05
EP0869960B1 (de) 2002-07-03
DE69622193T2 (de) 2003-03-20
ATE220069T1 (de) 2002-07-15
BE1009264A3 (nl) 1997-01-07
ES2179180T3 (es) 2003-01-16
KR19980703622A (ko) 1998-12-05
IN183010B (de) 1999-08-21
CN1103777C (zh) 2003-03-26
EP0869960A1 (de) 1998-10-14
CN1185157A (zh) 1998-06-17
MX9707550A (es) 1997-11-29
JPH11502832A (ja) 1999-03-09
CZ307497A3 (cs) 1998-01-14
WO1996030376A1 (en) 1996-10-03
AU4958296A (en) 1996-10-16

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: DSM IP ASSETS B.V., HEERLEN, NL

8339 Ceased/non-payment of the annual fee