DE69614711D1 - Verfahren zur gewinnung von cephalexin - Google Patents
Verfahren zur gewinnung von cephalexinInfo
- Publication number
- DE69614711D1 DE69614711D1 DE69614711T DE69614711T DE69614711D1 DE 69614711 D1 DE69614711 D1 DE 69614711D1 DE 69614711 T DE69614711 T DE 69614711T DE 69614711 T DE69614711 T DE 69614711T DE 69614711 D1 DE69614711 D1 DE 69614711D1
- Authority
- DE
- Germany
- Prior art keywords
- cephalexin
- adca
- recovered
- disclosed process
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 title abstract 6
- 229940106164 cephalexin Drugs 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- NVIAYEIXYQCDAN-CLZZGJSISA-N 7beta-aminodeacetoxycephalosporanic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](N)[C@@H]12 NVIAYEIXYQCDAN-CLZZGJSISA-N 0.000 abstract 4
- 238000005917 acylation reaction Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 230000010933 acylation Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 150000005331 phenylglycines Chemical class 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE9500081A BE1009071A3 (nl) | 1995-02-02 | 1995-02-02 | Werkwijze voor de bereiding van een beta-lactam antibioticum. |
| BE9500205A BE1009194A3 (nl) | 1995-03-09 | 1995-03-09 | Werkwijze voor de winning van cefalexine. |
| BE9500290A BE1009263A3 (nl) | 1995-03-31 | 1995-03-31 | Werkwijze voor de winning van cefalexine. |
| PCT/NL1996/000051 WO1996023796A1 (en) | 1995-02-02 | 1996-02-01 | Process for the recovery of cephalexin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69614711D1 true DE69614711D1 (de) | 2001-09-27 |
| DE69614711T2 DE69614711T2 (de) | 2002-06-27 |
Family
ID=27159841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69614711T Expired - Fee Related DE69614711T2 (de) | 1995-02-02 | 1996-02-01 | Verfahren zur gewinnung von cephalexin |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5874571A (de) |
| EP (1) | EP0869961B1 (de) |
| JP (1) | JPH11503408A (de) |
| KR (1) | KR100439322B1 (de) |
| CN (1) | CN1101395C (de) |
| AT (1) | ATE204580T1 (de) |
| AU (1) | AU4846196A (de) |
| CZ (1) | CZ241997A3 (de) |
| DE (1) | DE69614711T2 (de) |
| ES (1) | ES2163002T3 (de) |
| MX (1) | MX9705917A (de) |
| PL (1) | PL321626A1 (de) |
| WO (1) | WO1996023796A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE234846T1 (de) * | 1995-12-08 | 2003-04-15 | Dsm Nv | Verfahren zur herstellung eines anitibiotkums |
| BE1010651A3 (nl) * | 1996-09-27 | 1998-11-03 | Dsm Nv | Werkwijze voor het zuiveren van cefalexine. |
| NL1007076C2 (nl) * | 1997-09-19 | 1999-03-22 | Dsm Nv | Werkwijze voor de winning van een ß-lactam antibioticum. |
| NL1007077C2 (nl) * | 1997-09-19 | 1999-03-22 | Dsm Nv | Werkwijze voor de winning van een ß-lactam antibioticum. |
| US20040033262A1 (en) * | 2002-08-19 | 2004-02-19 | Orchid Health Care | Sustained release pharmaceutical composition of a cephalosporin antibiotic |
| CN1976747A (zh) * | 2004-06-30 | 2007-06-06 | 帝斯曼知识产权资产管理有限公司 | 包含beta－内酰胺抗生素的产品 |
| EP2723881A2 (de) | 2011-06-23 | 2014-04-30 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Neues kristallines cefoperazon-zwischenprodukt |
| WO2012175585A1 (en) | 2011-06-23 | 2012-12-27 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Process for preparing 3'-thiosubstituted cephalosporins employing a penicillin g acylase |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1001615A (en) * | 1971-12-04 | 1976-12-14 | Takeda Chemical Industries Ltd. | Method for purification of cephalexin |
| US4003896A (en) * | 1974-12-17 | 1977-01-18 | Novo Industri A/S | Method of preparing a sparingly soluble complex of cephalexin |
| JPS52111589A (en) * | 1976-03-16 | 1977-09-19 | Sangyo Kagaku Kenkyu Kyokai | Purification of antibiotics |
| JPH07502168A (ja) * | 1991-12-19 | 1995-03-09 | ジスト―ブロカデス ベスローテン フェンノートシャップ | 或る種のβ−ラクタム抗生物質の改善された製造方法 |
-
1996
- 1996-02-01 JP JP8523436A patent/JPH11503408A/ja active Pending
- 1996-02-01 DE DE69614711T patent/DE69614711T2/de not_active Expired - Fee Related
- 1996-02-01 AU AU48461/96A patent/AU4846196A/en not_active Abandoned
- 1996-02-01 PL PL96321626A patent/PL321626A1/xx unknown
- 1996-02-01 ES ES96904336T patent/ES2163002T3/es not_active Expired - Lifetime
- 1996-02-01 CN CN96192915A patent/CN1101395C/zh not_active Expired - Lifetime
- 1996-02-01 CZ CZ972419A patent/CZ241997A3/cs unknown
- 1996-02-01 AT AT96904336T patent/ATE204580T1/de active
- 1996-02-01 EP EP96904336A patent/EP0869961B1/de not_active Expired - Lifetime
- 1996-02-01 WO PCT/NL1996/000051 patent/WO1996023796A1/en active IP Right Grant
- 1996-02-01 KR KR1019970705249A patent/KR100439322B1/ko not_active IP Right Cessation
-
1997
- 1997-07-31 US US08/903,879 patent/US5874571A/en not_active Expired - Lifetime
- 1997-08-01 MX MX9705917A patent/MX9705917A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11503408A (ja) | 1999-03-26 |
| CN1101395C (zh) | 2003-02-12 |
| ATE204580T1 (de) | 2001-09-15 |
| ES2163002T3 (es) | 2002-01-16 |
| PL321626A1 (en) | 1997-12-08 |
| US5874571A (en) | 1999-02-23 |
| EP0869961B1 (de) | 2001-08-22 |
| KR100439322B1 (ko) | 2005-08-04 |
| EP0869961A1 (de) | 1998-10-14 |
| AU4846196A (en) | 1996-08-21 |
| CN1179779A (zh) | 1998-04-22 |
| CZ241997A3 (cs) | 1998-01-14 |
| KR19980701852A (ko) | 1998-06-25 |
| MX9705917A (es) | 1998-07-31 |
| WO1996023796A1 (en) | 1996-08-08 |
| DE69614711T2 (de) | 2002-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: DSM IP ASSETS B.V., HEERLEN, NL |
|
| 8339 | Ceased/non-payment of the annual fee |