BR9812338A - Processo para recuperação de um antibiótico de beta-lactama - Google Patents

Processo para recuperação de um antibiótico de beta-lactama

Info

Publication number
BR9812338A
BR9812338A BR9812338-6A BR9812338A BR9812338A BR 9812338 A BR9812338 A BR 9812338A BR 9812338 A BR9812338 A BR 9812338A BR 9812338 A BR9812338 A BR 9812338A
Authority
BR
Brazil
Prior art keywords
lactam antibiotic
solid
temperature
beta
lactam
Prior art date
Application number
BR9812338-6A
Other languages
English (en)
Inventor
Wilhelmus Hubertus Jos Boesten
Harold Monro Moody
Hubertus Maria Jozef Grooten
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Publication of BR9812338A publication Critical patent/BR9812338A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/18—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Abstract

Patente de Invenção: <B>"PROCESSO PARA RECUPERAçãO DE UM ANTIBIóTICO DE BETA-LACTAMA"<D>. A presente invenção refere-se a um processo para recuperação de um antibiótico de <225>-lactama de uma mistura que contém o antibiótico de <225>-lactama e D-fenil glicina (FG) em solução, com a mistura sendo trazida para um pH entre 3 e 8, a uma temperatura entre -5 e 20°C e a uma concentração tal que FG permanece em solução, o antibiótico sólido de <225>-lactama obtido sendo recuperado e o líquido restante sendo submetido a um aumento de temperatura, para uma temperatura entre 10 e 60°C, com formação de FG sólida, a FG sendo separada como sólida e o licor mãe sendo pelo menos parcialmente recirculado. Preferencialmente, o uso é feito a partir de uma mistura inicial, contendo substancialmente o antibiótico de <225>-lactama e a D-fenil glicina FG, originários de uma reação de acilação enzimática, em que o núcleo correspondente de <225>-lactama, em particular o ácido 6-aminopenicilânico, o ácido 7-aminodesacetoxicefalosporânico e o ácido 7-amino-3-cloro-cef-3-em-4-carboxílico, são acilados com um derivado de D-fenil glicina.
BR9812338-6A 1997-09-19 1998-09-18 Processo para recuperação de um antibiótico de beta-lactama BR9812338A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1007076A NL1007076C2 (nl) 1997-09-19 1997-09-19 Werkwijze voor de winning van een ß-lactam antibioticum.
PCT/NL1998/000539 WO1999015532A1 (en) 1997-09-19 1998-09-18 PROCESS FOR RECOVERY OF A β-LACTAM ANTIBIOTIC

Publications (1)

Publication Number Publication Date
BR9812338A true BR9812338A (pt) 2000-09-19

Family

ID=19765706

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812338-6A BR9812338A (pt) 1997-09-19 1998-09-18 Processo para recuperação de um antibiótico de beta-lactama

Country Status (10)

Country Link
EP (1) EP1017699A1 (pt)
KR (1) KR20010024027A (pt)
CN (1) CN1279684A (pt)
AU (1) AU9189898A (pt)
BR (1) BR9812338A (pt)
EG (1) EG21220A (pt)
IN (1) IN187839B (pt)
NL (1) NL1007076C2 (pt)
TR (1) TR200000881T2 (pt)
WO (1) WO1999015532A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1006266C2 (nl) 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
CN102851332A (zh) * 2012-09-07 2013-01-02 石药集团中诺药业（石家庄）有限公司 一种酶法氨苄西林母液中d（-）苯甘氨酸的回收方法
CN103193800B (zh) * 2013-04-08 2016-03-02 中国医药集团总公司四川抗菌素工业研究所 一种从头孢克洛酶促反应液中分离纯化各组分的方法
CN106220646B (zh) * 2016-07-29 2018-08-24 华北制药河北华民药业有限责任公司 一种酶法合成头孢氨苄母液的循环利用的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034522A (en) * 1988-08-02 1991-07-23 Biocraft Laboratories, Inc. Method for the production of 3-methyl cephem derivatives
BE1007296A3 (nl) * 1993-07-19 1995-05-09 Dsm Nv Werkwijze voor de bereiding van een beta-lactamderivaat.
PL321626A1 (en) * 1995-02-02 1997-12-08 Chemferm Vof Method of recovering ceophalexin
BE1009264A3 (nl) * 1995-03-31 1997-01-07 Dsm Nv Werkwijze voor de winning van ampicilline.
CN1107070C (zh) * 1995-12-08 2003-04-30 吉斯特·布罗卡迪斯股份有限公司 制备抗生素的方法
NL1002818C2 (nl) * 1996-04-09 1997-10-15 Chemferm Vof Werkwijze voor de bereiding van beta-lactam antibiotica.

Also Published As

Publication number Publication date
IN187839B (pt) 2002-06-29
EG21220A (en) 2001-02-28
NL1007076C2 (nl) 1999-03-22
EP1017699A1 (en) 2000-07-12
KR20010024027A (ko) 2001-03-26
TR200000881T2 (tr) 2001-07-23
CN1279684A (zh) 2001-01-10
WO1999015532A1 (en) 1999-04-01
AU9189898A (en) 1999-04-12

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5O, 6O, 7O, 8O E 9O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1909 DE 07/08/2007.