TR200000880T2 - ß-laktam antibiyotiğin geri kazanılması için bir işlem. - Google Patents

ß-laktam antibiyotiğin geri kazanılması için bir işlem.

Info

Publication number
TR200000880T2
TR200000880T2 TR2000/00880T TR200000880T TR200000880T2 TR 200000880 T2 TR200000880 T2 TR 200000880T2 TR 2000/00880 T TR2000/00880 T TR 2000/00880T TR 200000880 T TR200000880 T TR 200000880T TR 200000880 T2 TR200000880 T2 TR 200000880T2
Authority
TR
Turkey
Prior art keywords
lactam antibiotic
lactam
solid
solution
antibiotic
Prior art date
Application number
TR2000/00880T
Other languages
English (en)
Inventor
Edmund Kers Ernst
Monro Moody Harold
Original Assignee
Dsm N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm N.V. filed Critical Dsm N.V.
Publication of TR200000880T2 publication Critical patent/TR200000880T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/18—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Solüsyon halinde -laktam antibiyotik ve D-fenil glisin (FG) içeren bir karisimdan -laktam antibiyotigin geri kazanilmasi için bir islemde, karisim, FG'nin solüsyonda kalmasini saglayacak bir konsantrasyonda 3-8 arasi bir pH'a getirilir; elde edilen kati -laktam antibiyotik geri kazanilir ve geri kalan sivi, bir konsantrasyon basamagina maruz birakilir; bu basamakta, kati -laktam antibiyotik ve kati FG'ye sahip bir bulamaç gelisir; bulamaç, -laktam antibiyotigin çözündügü bir pH'a getirilir; FG bir kati olarak ayrilir ve ana çözeltide bulunan -laktam antibiyotik, en azindan kismen kullanilir. Tercihen, uygun -laktam çekirdegi, özellikle 6-aminopenisilanik asit, 7-aminodezasetoksisefalosporanik asit ve 7-amino-3-kloro-cef-3-em-4-karboksilik asidin, D-fenil glisin türevi ile asillendigi enzimatik bir asilleme reaksiyonundan kaynaklanan -laktam antibiyotik ve FG içeren bir baslangiç karisimi kullanilir.
TR2000/00880T 1997-09-19 1998-09-18 ß-laktam antibiyotiğin geri kazanılması için bir işlem. TR200000880T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL1007077A NL1007077C2 (nl) 1997-09-19 1997-09-19 Werkwijze voor de winning van een ß-lactam antibioticum.

Publications (1)

Publication Number Publication Date
TR200000880T2 true TR200000880T2 (tr) 2000-11-21

Family

ID=19765707

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00880T TR200000880T2 (tr) 1997-09-19 1998-09-18 ß-laktam antibiyotiğin geri kazanılması için bir işlem.

Country Status (9)

Country Link
EP (1) EP1017698A1 (tr)
KR (1) KR20010024028A (tr)
CN (1) CN1279685A (tr)
AU (1) AU9189798A (tr)
BR (1) BR9812482A (tr)
IN (1) IN188409B (tr)
NL (1) NL1007077C2 (tr)
TR (1) TR200000880T2 (tr)
WO (1) WO1999015531A1 (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1006266C2 (nl) 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
CN102851332A (zh) * 2012-09-07 2013-01-02 石药集团中诺药业（石家庄）有限公司 一种酶法氨苄西林母液中d（-）苯甘氨酸的回收方法
CN103805671B (zh) * 2013-11-11 2015-08-26 华北制药河北华民药业有限责任公司 一种制备头孢氨苄的方法
CN106317076B (zh) * 2016-07-29 2018-08-24 华北制药河北华民药业有限责任公司 一种7-adca母液回收的方法
CN106220646B (zh) * 2016-07-29 2018-08-24 华北制药河北华民药业有限责任公司 一种酶法合成头孢氨苄母液的循环利用的方法
CN106526106A (zh) * 2016-12-07 2017-03-22 百奥森（江苏）食品安全科技有限公司 一种乳品中β‑内酰胺的检测方法
CN108084206B (zh) * 2018-02-09 2019-04-26 国药集团威奇达药业有限公司 从酶法合成氨苄西林母液中回收氨苄西林的方法
CN111269076A (zh) * 2020-03-12 2020-06-12 山东钧睿科技服务有限公司 一种酶法合成β-内酰胺类抗生素离心母液回收处理工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5034522A (en) * 1988-08-02 1991-07-23 Biocraft Laboratories, Inc. Method for the production of 3-methyl cephem derivatives
BE1007296A3 (nl) * 1993-07-19 1995-05-09 Dsm Nv Werkwijze voor de bereiding van een beta-lactamderivaat.
EP0869961B1 (en) * 1995-02-02 2001-08-22 Dsm N.V. Process for the recovery of cephalexin
BE1009264A3 (nl) * 1995-03-31 1997-01-07 Dsm Nv Werkwijze voor de winning van ampicilline.
ATE234846T1 (de) * 1995-12-08 2003-04-15 Dsm Nv Verfahren zur herstellung eines anitibiotkums
NL1002818C2 (nl) * 1996-04-09 1997-10-15 Chemferm Vof Werkwijze voor de bereiding van beta-lactam antibiotica.

Also Published As

Publication number Publication date
WO1999015531A1 (en) 1999-04-01
EP1017698A1 (en) 2000-07-12
CN1279685A (zh) 2001-01-10
IN188409B (tr) 2002-09-21
NL1007077C2 (nl) 1999-03-22
AU9189798A (en) 1999-04-12
BR9812482A (pt) 2000-09-19
KR20010024028A (ko) 2001-03-26

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