EP1102578A4 - A new analgesic, anti-inflammatory and wound healing agent - Google Patents

A new analgesic, anti-inflammatory and wound healing agent

Info

Publication number
EP1102578A4
EP1102578A4 EP99942002A EP99942002A EP1102578A4 EP 1102578 A4 EP1102578 A4 EP 1102578A4 EP 99942002 A EP99942002 A EP 99942002A EP 99942002 A EP99942002 A EP 99942002A EP 1102578 A4 EP1102578 A4 EP 1102578A4
Authority
EP
European Patent Office
Prior art keywords
inflammatory
wound healing
healing agent
new analgesic
analgesic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99942002A
Other languages
German (de)
French (fr)
Other versions
EP1102578A1 (en
Inventor
Jonathan W Nyce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenesis Pharmaceuticals Inc
Original Assignee
Epigenesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenesis Pharmaceuticals Inc filed Critical Epigenesis Pharmaceuticals Inc
Publication of EP1102578A1 publication Critical patent/EP1102578A1/en
Publication of EP1102578A4 publication Critical patent/EP1102578A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
EP99942002A 1998-08-03 1999-08-03 A new analgesic, anti-inflammatory and wound healing agent Withdrawn EP1102578A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9509098P 1998-08-03 1998-08-03
US95090P 1998-08-03
PCT/US1999/017642 WO2000007566A1 (en) 1998-08-03 1999-08-03 A new analgesic, anti-inflammatory and wound healing agent

Publications (2)

Publication Number Publication Date
EP1102578A1 EP1102578A1 (en) 2001-05-30
EP1102578A4 true EP1102578A4 (en) 2005-05-18

Family

ID=22249490

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99942002A Withdrawn EP1102578A4 (en) 1998-08-03 1999-08-03 A new analgesic, anti-inflammatory and wound healing agent

Country Status (6)

Country Link
EP (1) EP1102578A4 (en)
CN (1) CN1311665A (en)
AU (1) AU5547099A (en)
CA (1) CA2348637A1 (en)
MX (1) MXPA01000973A (en)
WO (1) WO2000007566A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000040172A1 (en) * 1999-01-05 2000-07-13 East Carolina University Composition and formulations and their use as nociceptic, anti-anxiolytic and anabolic agents
MXPA06014026A (en) * 2004-07-02 2007-02-08 Warner Lambert Co Compositions and methods for treating pathological infections.
HU227970B1 (en) 2007-07-10 2012-07-30 Egis Gyogyszergyar Nyrt Pharmaceutical compositions containing silicones of high volatility
CN101417121B (en) * 2007-10-27 2011-09-28 董昌金 Medicine capable of curing skin burning and freezing injury
US10045935B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US11154535B2 (en) 2012-07-31 2021-10-26 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
JP6362268B2 (en) * 2012-11-05 2018-07-25 塩野義製薬株式会社 Method for evaluating drug efficacy and screening method for EL activity inhibitory substance having therapeutic or preventive effect on diseases associated with EL activity

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382019A1 (en) * 1989-01-31 1990-08-16 BIORESEARCH S.p.A. Use of 5-methyltetrahydrofolic acid, of 5-formyl-tetrahydrofolic acid and of their pharmaceutically acceptable salts for the preparation of controlled release pharmaceutical compositions suitable for the use in the therapy of depressive disturbances, and pharmaceutical compositions thus prepared
US5118505A (en) * 1988-01-28 1992-06-02 Koeltringer Peter Combination preparation for the treatment of nerve cell and nerve fibre diseases and injury
WO1998019690A1 (en) * 1996-11-06 1998-05-14 Bristol-Myers Squibb Company Method for treating alzheimer's disease
EP0898965A2 (en) * 1997-06-13 1999-03-03 EPROVA Aktiengesellschaft Use of tetrahydrofolates for modulating the homocysteine level
WO2000040172A1 (en) * 1999-01-05 2000-07-13 East Carolina University Composition and formulations and their use as nociceptic, anti-anxiolytic and anabolic agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5419996A (en) * 1977-07-08 1979-02-15 Wellcome Found Pyrimido*4*55c*pyridazines
CH673459A5 (en) * 1987-05-15 1990-03-15 Eprova Ag
US5534513A (en) * 1991-09-05 1996-07-09 Taiho Pharmaceutical Company, Ltd. Antitumor potentiator and antitumor composition
US5438075A (en) * 1993-03-30 1995-08-01 Skubitz; Keith M. Oral glutamine to reduce stomatitis
US5660835A (en) * 1995-02-24 1997-08-26 East Carolina University Method of treating adenosine depletion
PT877563E (en) * 1996-01-31 2004-08-31 Univ South Alabama FOOD AND VITAMINIC PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118505A (en) * 1988-01-28 1992-06-02 Koeltringer Peter Combination preparation for the treatment of nerve cell and nerve fibre diseases and injury
EP0382019A1 (en) * 1989-01-31 1990-08-16 BIORESEARCH S.p.A. Use of 5-methyltetrahydrofolic acid, of 5-formyl-tetrahydrofolic acid and of their pharmaceutically acceptable salts for the preparation of controlled release pharmaceutical compositions suitable for the use in the therapy of depressive disturbances, and pharmaceutical compositions thus prepared
WO1998019690A1 (en) * 1996-11-06 1998-05-14 Bristol-Myers Squibb Company Method for treating alzheimer's disease
EP0898965A2 (en) * 1997-06-13 1999-03-03 EPROVA Aktiengesellschaft Use of tetrahydrofolates for modulating the homocysteine level
WO2000040172A1 (en) * 1999-01-05 2000-07-13 East Carolina University Composition and formulations and their use as nociceptic, anti-anxiolytic and anabolic agents

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CASTRO ALONSO F J ET AL: "Treatment of ocular toxoplasmosis", FARMACIA CLINICA, vol. 15, no. 2, March 1998 (1998-03-01), pages 119 - 124, XP009045489, ISSN: 0212-6583 *
DAVIES ET AL: "FACILITATORY AND DIRECT EXCITATORY EFFECTS OF FOLATE AND FOLINATE ON SINGLE NEURONES OF CAT CEREBRAL CORTEX", BIOCHEMICAL PHARMACOLOGY, PERGAMON, OXFORD, GB, vol. 13, no. 22, 1 July 1973 (1973-07-01), pages 1667 - 1668, XP001078712, ISSN: 0006-2952 *
KELLY G S: "Folates: supplemental forms and therapeutic applications.", ALTERNATIVE MEDICINE REVIEW : A JOURNAL OF CLINICAL THERAPEUTIC. JUN 1998, vol. 3, no. 3, June 1998 (1998-06-01), pages 208 - 220, XP009045488, ISSN: 1089-5159 *
KEPKA L ET AL: "Successful rescue in a patient with high dose methotrexate-induced nephrotoxicity and acute renal failure.", LEUKEMIA & LYMPHOMA. MAR 1998, vol. 29, no. 1-2, March 1998 (1998-03-01), pages 205 - 209, XP009045482, ISSN: 1042-8194 *
See also references of WO0007566A1 *

Also Published As

Publication number Publication date
CA2348637A1 (en) 2000-02-17
CN1311665A (en) 2001-09-05
WO2000007566A1 (en) 2000-02-17
EP1102578A1 (en) 2001-05-30
MXPA01000973A (en) 2002-06-04
AU5547099A (en) 2000-02-28

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20010131

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: EPIGENESIS PHARMACEUTICALS, INC.

A4 Supplementary search report drawn up and despatched

Effective date: 20050406

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61P 29/00 B

Ipc: 7A 61P 25/00 B

Ipc: 7A 61P 23/00 B

Ipc: 7A 61P 13/12 B

Ipc: 7A 61P 9/00 B

Ipc: 7A 61P 3/00 B

Ipc: 7A 61K 45/06 B

Ipc: 7A 61K 31/519 A

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20050301