DE69029186D1 - 3-Indolbrenztraubensäure, Verfahren zu deren Herstellung und deren therapeutische Verwendung - Google Patents

3-Indolbrenztraubensäure, Verfahren zu deren Herstellung und deren therapeutische Verwendung

Info

Publication number
DE69029186D1
DE69029186D1 DE69029186T DE69029186T DE69029186D1 DE 69029186 D1 DE69029186 D1 DE 69029186D1 DE 69029186 T DE69029186 T DE 69029186T DE 69029186 T DE69029186 T DE 69029186T DE 69029186 D1 DE69029186 D1 DE 69029186D1
Authority
DE
Germany
Prior art keywords
preparation
therapeutic use
pyruvic acid
indole pyruvic
indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69029186T
Other languages
English (en)
Other versions
DE69029186T2 (de
Inventor
Vincenzo Politi
Luca Giovanna De
Stazio Giovanni Di
Mario Materazzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polifarma SpA
Original Assignee
Polifarma SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polifarma SpA filed Critical Polifarma SpA
Publication of DE69029186D1 publication Critical patent/DE69029186D1/de
Application granted granted Critical
Publication of DE69029186T2 publication Critical patent/DE69029186T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
DE69029186T 1989-10-04 1990-09-07 3-Indolbrenztraubensäure, Verfahren zu deren Herstellung und deren therapeutische Verwendung Expired - Fee Related DE69029186T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT04842689A IT1237472B (it) 1989-10-04 1989-10-04 Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.

Publications (2)

Publication Number Publication Date
DE69029186D1 true DE69029186D1 (de) 1997-01-02
DE69029186T2 DE69029186T2 (de) 1997-03-27

Family

ID=11266474

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69029186T Expired - Fee Related DE69029186T2 (de) 1989-10-04 1990-09-07 3-Indolbrenztraubensäure, Verfahren zu deren Herstellung und deren therapeutische Verwendung

Country Status (4)

Country Link
US (1) US5210215A (de)
EP (1) EP0421946B1 (de)
DE (1) DE69029186T2 (de)
IT (1) IT1237472B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643365B2 (en) * 1991-02-28 1993-11-11 Aventisub Ii Inc. NMDA antagonists
US5484814A (en) * 1991-02-28 1996-01-16 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
US5360814A (en) * 1991-02-28 1994-11-01 Merrell Dow Pharmaceuticals Inc. NMDA antagonists
CN1079395C (zh) * 1998-03-18 2002-02-20 谭敦宪 N－乙酰－5,6－二甲氧基色胺的生产方法
US6608196B2 (en) 2001-05-03 2003-08-19 Galileo Pharmaceuticals, Inc. Process for solid supported synthesis of pyruvate-derived compounds
US6916850B2 (en) 2001-05-03 2005-07-12 Galileo Pharmaceuticals, Inc. Pyruvate derivatives
KR100673283B1 (ko) 2001-12-27 2007-01-24 아지노모토 가부시키가이샤 글루탐산 유도체의 제조방법
US7781396B2 (en) 2002-01-31 2010-08-24 Tel Aviv University Future Technology Development L.P. Peptides directed for diagnosis and treatment of amyloid-associated disease
US20040052928A1 (en) 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
ITRM20020255A1 (it) * 2002-05-09 2003-11-10 Polifarma Spa Tautomero enolico dell'acido 3-indolilpiruvico, suoi sali e usi terapeutici.
US7491699B2 (en) 2002-12-09 2009-02-17 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
EP1583713B1 (de) 2003-01-07 2009-03-25 Ramot at Tel Aviv University Ltd. Peptidenanostrukturen die fremdmaterial enthalten, und verfahren zur herstellung derselben
JP5137400B2 (ja) 2003-06-30 2013-02-06 テル アヴィヴ ユニヴァーシティ フューチャー テクノロジー ディヴェロップメント エル．ピー． アミロイド関連疾患を診断および処置するためのペプチド、それに対する抗体、ならびにその使用方法
EP1663199B1 (de) 2003-09-25 2013-04-03 Tel Aviv University Future Technology Development L.P. Zusammensetzungen und diese verwendende verfahren zur behandlung von amyloid-bedingten erkrankungen
WO2005031362A2 (en) * 2003-10-02 2005-04-07 Ramot At Tel Aviv University Ltd. Novel antibacterial agents and methods of identifying and utilizing same
PT1670444E (pt) 2003-10-03 2011-07-29 Veijlen N V Utilização de derivados do ácido indoleacético que aumentam o nível de igf-1 no soro para a preparação de uma composição terapêutica para o tratamento de várias doenças
US20070184091A1 (en) 2003-10-03 2007-08-09 Gillessen Hubert Jean M F Animal feed composition
US20090156471A1 (en) * 2004-07-15 2009-06-18 Ramot At Tel Aviv University Ltd. Use of anti-amyloid agents for treating and typing pathogen infections
WO2006013552A2 (en) 2004-08-02 2006-02-09 Ramot At Tel Aviv University Ltd. Articles of peptide nanostructures and method of forming the same
WO2006018850A2 (en) * 2004-08-19 2006-02-23 Tel Aviv University Future Technology Development L.P. Compositions for treating amyloid associated diseases
WO2006027780A2 (en) 2004-09-08 2006-03-16 Ramot At Tel Aviv University Ltd. Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same
WO2007043048A2 (en) 2005-10-11 2007-04-19 Ramot At Tel Aviv University Ltd. Self-assembled fmoc-ff hydrogels
US7879212B2 (en) 2005-11-03 2011-02-01 Ramot At Tel-Aviv University Ltd. Peptide nanostructure-coated electrodes
WO2009028338A1 (ja) 2007-08-24 2009-03-05 Ajinomoto Co., Inc. 新規オキシダーゼ遺伝子、および該遺伝子を利用する３－インドールピルビン酸の製造方法
CN102741406A (zh) 2010-10-14 2012-10-17 味之素株式会社 用于产生莽那亭的方法
TW201225972A (en) 2010-11-15 2012-07-01 Univ Ramot Dipeptide analogs for treating conditions associated with amyloid fibril formation
CN108315370A (zh) * 2018-01-19 2018-07-24 滨海吉尔多肽有限公司 一种卤素色氨酸的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2306693A1 (fr) * 1975-04-11 1976-11-05 Roussel Uclaf Nouveaux derives du /9h/pyrido/3,4-b/ indole et leurs sels, procede de preparation et application a titre de medicaments
IT1148618B (it) * 1982-10-11 1986-12-03 Polifarma Spa Procedimento enzimatico per la produzione di acido 3-indolpiruvico e utilizzazione farmaceutica di questo
DE3328348A1 (de) * 1983-08-05 1985-02-14 Degussa Ag, 6000 Frankfurt Verfahren zur duennschichtchromatographischen trennung von enantiomeren
IT1184282B (it) * 1985-06-28 1987-10-22 Polifarma Spa Procedimento per la produzione di alfa-chetoacidi indolici a partire da un rispettivo alfa-ammino-acido,particolarmente per produrre acido indolpiruvico
IT1206078B (it) * 1987-06-03 1989-04-14 Polifarma Spa Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico

Also Published As

Publication number Publication date
EP0421946A3 (en) 1992-01-22
IT1237472B (it) 1993-06-07
EP0421946B1 (de) 1996-11-20
DE69029186T2 (de) 1997-03-27
EP0421946A2 (de) 1991-04-10
IT8948426A0 (it) 1989-10-04
US5210215A (en) 1993-05-11

Similar Documents

Publication Publication Date Title
DE69029186T2 (de) 3-Indolbrenztraubensäure, Verfahren zu deren Herstellung und deren therapeutische Verwendung
DE58909834D1 (de) Phthalimidoperoxihexansäure, Verfahren zu deren Herstellung und deren Verwendung
DE69006290T2 (de) N-Substituierte Benzyloxyiminderivate, Verfahren zu deren Herstellung und deren Verwendung.
DE3786781T2 (de) 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-en-2-carbonsäure-Derivate und Verfahren zu deren Herstellung.
DE69029151D1 (de) Modifizierte Polyesterzusammensetzung, Verfahren zu deren Herstellung und deren Verwendung
DE19581622T1 (de) Wäßrige Harzzusammensetzung, Verfahren zu deren Herstellung und deren Verwendung
DE69125557T2 (de) Sauerstoffelektrode und Verfahren zu deren Herstellung
DE3650018T2 (de) Chinolin-Derivate und Verfahren zu deren Herstellung.
DE68928437T2 (de) Elektrode und Verfahren zu deren Herstellung
DE69122687T2 (de) Cellulase, Verfahren zu deren Herstellung und deren Verwendung
DE3689748D1 (de) Benzimidazolderivate, Verfahren zu deren Herstellung und deren therapeutische Anwendung.
DE3853608T2 (de) Zyklische Anthranil-carbonsäurederivate und Verfahren zu deren Herstellung.
ATA56790A (de) Thieno-triazolo-diazepinderivate, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
DE69105369D1 (de) Pastenzusammensetzung und Verfahren zu deren Herstellung.
ATA95690A (de) Thieno-triazolo-diazepinderivate, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
ATA260590A (de) Glyzerinderivate, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
DE68920063D1 (de) Derivate von Benzoesäure und Verfahren zu deren Herstellung.
ATA328587A (de) Neue furanuronsaeure-derivate, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
PT84123A (de) Substituierte 4-amino-3-hydroxybuttersaure-derivate verfahren zu deren herstellung diese enthaltende mittel und ihre verwendung
ATA146488A (de) 2-methoxymethylpenemverbindungen, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
PT84565A (de) Substituierte 4-amino-3-hydroxybuttersauere-derivate verfahren zu deren herstellung diese enthaltende mittel und ihre verwendung
DE69024910D1 (de) Natürliche Delta-Lactone und Verfahren zu deren Herstellung
DE68923442T2 (de) N-substituierte Acylaminosäure-Verbindungen, Verfahren zu deren Herstellung und deren Verwendung.
DE69021127T2 (de) Polyisocyanatoalkylphenyl-isocyanurates, Verfahren zu deren Herstellung und deren Verwendung.
ATA259590A (de) 3-(n-methyl-n-alkyl)-amino-2-methoxymethylenpro an-1-ol-derivate, verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee