ATE192045T1 - Verwendung von substituierten adeninderivaten zur behandlung von multiplesklerose - Google Patents

Verwendung von substituierten adeninderivaten zur behandlung von multiplesklerose

Info

Publication number
ATE192045T1
ATE192045T1 AT93906071T AT93906071T ATE192045T1 AT E192045 T1 ATE192045 T1 AT E192045T1 AT 93906071 T AT93906071 T AT 93906071T AT 93906071 T AT93906071 T AT 93906071T AT E192045 T1 ATE192045 T1 AT E192045T1
Authority
AT
Austria
Prior art keywords
multiple sclerosis
treatment
adenine derivatives
substituted adenine
formula
Prior art date
Application number
AT93906071T
Other languages
English (en)
Inventor
Ernest Beutler
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE192045T1 publication Critical patent/ATE192045T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT93906071T 1992-02-19 1993-02-18 Verwendung von substituierten adeninderivaten zur behandlung von multiplesklerose ATE192045T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/838,546 US5310732A (en) 1986-02-03 1992-02-19 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
PCT/US1993/001467 WO1993016706A1 (en) 1992-02-19 1993-02-18 Use of substituted adenine derivatives for treating multiple sclerosis

Publications (1)

Publication Number Publication Date
ATE192045T1 true ATE192045T1 (de) 2000-05-15

Family

ID=25277387

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93906071T ATE192045T1 (de) 1992-02-19 1993-02-18 Verwendung von substituierten adeninderivaten zur behandlung von multiplesklerose

Country Status (15)

Country Link
US (4) US5310732A (de)
EP (1) EP0626853B1 (de)
JP (1) JP2688113B2 (de)
AT (1) ATE192045T1 (de)
AU (1) AU682818B2 (de)
BR (1) BR9305907A (de)
CA (1) CA2130275C (de)
CH (1) CH684310A5 (de)
DE (1) DE69328474T2 (de)
DK (1) DK0626853T3 (de)
FI (1) FI943805L (de)
HU (1) HU218656B (de)
NO (2) NO309025B1 (de)
RU (1) RU2130308C1 (de)
WO (1) WO1993016706A1 (de)

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US5424296A (en) * 1993-04-15 1995-06-13 The Scripps Research Institute 2-Halo-2'-deoxyadenosines as therapeutic agents against malignant astrocytoma
US5672622A (en) * 1994-04-21 1997-09-30 Berlex Laboratories, Inc. Treatment of multiple sclerosis
US5773570A (en) * 1994-05-20 1998-06-30 The Regents Of The University Of California Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis
US7094597B1 (en) * 1994-05-20 2006-08-22 The Regents Of The University Of California Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis
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US6060501A (en) * 1994-06-02 2000-05-09 Schering Aktiengesellschaft Combined treatment of multiple sclerosis
WO1996003134A1 (en) * 1994-07-21 1996-02-08 Thomas Jefferson University Treatment of diarrhea with 2-substituted adenosine derivatives
US5510336A (en) * 1994-09-06 1996-04-23 Saven; Alan 2-halo-2'-deoxyadenosine treatment for histiocytosis
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US5811073A (en) * 1995-06-19 1998-09-22 President And Fellows Of Harvard College Method for radioisotopic detection and localization of inflammation in a host
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WO2002036611A2 (en) 2000-11-01 2002-05-10 The Regents Of The University Of California Immunomodulatory peptides derived from heat shock proteins and uses thereof
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US7368423B1 (en) * 2001-12-05 2008-05-06 The Scripps Research Institute Composition and method for treating chronic allograft rejection
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JP2008524310A (ja) * 2004-12-22 2008-07-10 ラボラトワール セローノ ソシエテ アノニム 多発性硬化症の組み合せ治療
US8658622B2 (en) 2005-01-14 2014-02-25 Regents Of The University Of California Methods and compositions for preventing and treating a disease related to glycan dysregulation
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EP2343074A1 (de) 2009-12-23 2011-07-13 Merck Serono S.A. Verwendung von Purinanaloga zur Behandlung von Atemwegserkrankungen
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EP2971287B1 (de) 2013-03-15 2019-08-14 GPB Scientific, LLC Mikrofluidische on-chip-verarbeitung von partikeln
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
EP3608022A1 (de) 2013-03-15 2020-02-12 The Trustees of Princeton University Verfahren und vorrichtungen für reinigung mit hohem durchsatz
GB201401465D0 (en) 2014-01-29 2014-03-12 Roach Arthur H Use of cladribine for treating autoimmune inflammatory disease
US9839625B2 (en) 2014-11-06 2017-12-12 Northwestern University Inhibition of cancer cell motility
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CA2996529A1 (en) * 2015-08-24 2017-03-02 Gpb Scientific, Llc Methods and devices for multi-step cell purification and concentration
GB2564717A (en) 2017-07-21 2019-01-23 Chord Therapeutics S A R L Use of cladribine for treating autoimmune neuromuscular disease
CN119097635A (zh) 2017-11-24 2024-12-10 默克专利股份公司 用于治疗进展型形式的多发性硬化症的克拉屈滨疗法
US20240226284A1 (en) 2020-09-10 2024-07-11 Merck Patent Gmbh Novel treatment regimen for the treatment of autoimmune disorders
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Also Published As

Publication number Publication date
FI943805A7 (fi) 1994-10-19
US5506213A (en) 1996-04-09
JPH07507540A (ja) 1995-08-24
WO1993016706A1 (en) 1993-09-02
NO20000762L (no) 1994-09-13
NO309025B1 (no) 2000-12-04
HU218656B (hu) 2000-10-28
CH684310A5 (de) 1994-08-31
DK0626853T3 (da) 2000-08-07
NO942765L (no) 1994-09-13
DE69328474D1 (de) 2000-05-31
FI943805A0 (fi) 1994-08-18
JP2688113B2 (ja) 1997-12-08
RU94038043A (ru) 1996-11-20
EP0626853A1 (de) 1994-12-07
RU2130308C1 (ru) 1999-05-20
US5541164A (en) 1996-07-30
US5310732A (en) 1994-05-10
DE69328474T2 (de) 2000-09-28
CA2130275A1 (en) 1993-09-02
NO322328B1 (no) 2006-09-18
US5506214A (en) 1996-04-09
HUT68030A (en) 1995-05-29
FI943805L (fi) 1994-10-19
HU9402392D0 (en) 1994-10-28
EP0626853B1 (de) 2000-04-26
CA2130275C (en) 1999-06-29
NO20000762D0 (no) 2000-02-16
NO942765D0 (no) 1994-07-25
AU682818B2 (en) 1997-10-23
BR9305907A (pt) 1997-10-21
AU3724993A (en) 1993-09-13

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