FI943805A0 - Substituoituja adeniinijohdannaisten käyttö multippeliskleroosin hoitoon - Google Patents

Substituoituja adeniinijohdannaisten käyttö multippeliskleroosin hoitoon

Info

Publication number
FI943805A0
FI943805A0 FI943805A FI943805A FI943805A0 FI 943805 A0 FI943805 A0 FI 943805A0 FI 943805 A FI943805 A FI 943805A FI 943805 A FI943805 A FI 943805A FI 943805 A0 FI943805 A0 FI 943805A0
Authority
FI
Finland
Prior art keywords
multiple sclerosis
treatment
adenine derivatives
substituted adenine
formula
Prior art date
Application number
FI943805A
Other languages
English (en)
Swedish (sv)
Other versions
FI943805A (fi
Inventor
Ernest Beutler
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of FI943805A0 publication Critical patent/FI943805A0/fi
Publication of FI943805A publication Critical patent/FI943805A/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI943805A 1992-02-19 1994-08-18 Substituoituja adeniinijohdannaisten käyttö multippeliskleroosin hoitoon FI943805A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/838,546 US5310732A (en) 1986-02-03 1992-02-19 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
PCT/US1993/001467 WO1993016706A1 (en) 1992-02-19 1993-02-18 Use of substituted adenine derivatives for treating multiple sclerosis

Publications (2)

Publication Number Publication Date
FI943805A0 true FI943805A0 (fi) 1994-08-18
FI943805A FI943805A (fi) 1994-10-19

Family

ID=25277387

Family Applications (1)

Application Number Title Priority Date Filing Date
FI943805A FI943805A (fi) 1992-02-19 1994-08-18 Substituoituja adeniinijohdannaisten käyttö multippeliskleroosin hoitoon

Country Status (15)

Country Link
US (4) US5310732A (fi)
EP (1) EP0626853B1 (fi)
JP (1) JP2688113B2 (fi)
AT (1) ATE192045T1 (fi)
AU (1) AU682818B2 (fi)
BR (1) BR9305907A (fi)
CA (1) CA2130275C (fi)
CH (1) CH684310A5 (fi)
DE (1) DE69328474T2 (fi)
DK (1) DK0626853T3 (fi)
FI (1) FI943805A (fi)
HU (1) HU218656B (fi)
NO (2) NO309025B1 (fi)
RU (1) RU2130308C1 (fi)
WO (1) WO1993016706A1 (fi)

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US5310732A (en) * 1986-02-03 1994-05-10 The Scripps Research Institute 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
US5624913A (en) * 1991-04-05 1997-04-29 Wisconsin Alumni Research Foundation Method reducing TNF-alpha in mammals with cerebral malaria
WO1993023058A1 (en) * 1992-05-19 1993-11-25 The Scripps Research Institute Use of 2-halo adenine derivatives as therapeutic agents against chronic myelogenous leukemia
US5424296A (en) * 1993-04-15 1995-06-13 The Scripps Research Institute 2-Halo-2'-deoxyadenosines as therapeutic agents against malignant astrocytoma
US5672622A (en) * 1994-04-21 1997-09-30 Berlex Laboratories, Inc. Treatment of multiple sclerosis
US5773570A (en) * 1994-05-20 1998-06-30 The Regents Of The University Of California Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis
US7094597B1 (en) * 1994-05-20 2006-08-22 The Regents Of The University Of California Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis
WO1995032718A1 (en) * 1994-05-26 1995-12-07 The Scripps Research Institute 2-halo-2'-deoxyadenosine treatement for inflammatory bowel disease
US6060501A (en) * 1994-06-02 2000-05-09 Schering Aktiengesellschaft Combined treatment of multiple sclerosis
US5817641A (en) * 1994-07-21 1998-10-06 Thomas Jefferson University Treatment of enterotoxigenic diarrhea with 2-substituted adenosine derivatives
US5510336A (en) * 1994-09-06 1996-04-23 Saven; Alan 2-halo-2'-deoxyadenosine treatment for histiocytosis
US5641757A (en) * 1994-12-21 1997-06-24 Ortho Pharmaceutical Corporation Stable 2-chloro-2'-deoxyadenosine formulations
PT801571E (pt) * 1994-12-22 2002-12-31 Ortho Pharma Corp Formulacoes soluveis de 2-cloro-2'-desoxiadenosina
AU762821B2 (en) * 1994-12-22 2003-07-03 Ortho-Mcneil Pharmaceutical, Inc. 'Soluble 2-chloro-2'-deoxyadenosine formulations'
SK283821B6 (sk) * 1995-02-10 2004-02-03 Schering Aktiengesellschaft Farmaceutické preparáty na inhibíciu tumornekrózafaktora
US5811073A (en) * 1995-06-19 1998-09-22 President And Fellows Of Harvard College Method for radioisotopic detection and localization of inflammation in a host
US6096310A (en) * 1997-04-15 2000-08-01 Bier; Milan Oral immunotherapy of bacterial overgrowth
US6617171B2 (en) 1998-02-27 2003-09-09 The General Hospital Corporation Methods for diagnosing and treating autoimmune disease
US6174873B1 (en) 1998-11-04 2001-01-16 Supergen, Inc. Oral administration of adenosine analogs
AU6234000A (en) * 1999-07-22 2001-02-13 Supergen, Inc. Methods for treating autoimmune diseases
US6358939B1 (en) 1999-12-21 2002-03-19 Northern Lights Pharmaceuticals, Llc Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
AU2001238516B2 (en) * 2000-02-18 2005-08-04 Southern Research Institute Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H- purin-6-amine
US7608683B2 (en) * 2000-08-09 2009-10-27 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
US6989146B2 (en) * 2000-08-09 2006-01-24 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
CA2427572A1 (en) 2000-11-01 2002-05-10 The Regents Of The University Of California Immunomodulatory peptides derived from heat shock proteins and uses thereof
WO2002078446A1 (en) * 2001-03-29 2002-10-10 Bioenergy Inc. Composition to reduce exercise-induced swelling of joints
US7528247B2 (en) * 2001-08-02 2009-05-05 Genzyme Corporation Process for preparing purine nucleosides
US7368423B1 (en) * 2001-12-05 2008-05-06 The Scripps Research Institute Composition and method for treating chronic allograft rejection
AU2003276988B2 (en) * 2002-09-27 2009-11-05 Bioenvision, Inc. Methods and compositions for the treatment of autoimmune disorders using clofarabine
CA2500091A1 (en) * 2002-09-27 2004-04-08 Bioenvision, Inc. Methods and compositions for the treatment of lupus using clofarabine
US20040087527A1 (en) * 2002-10-31 2004-05-06 Day Brian J. Methods for treatment of thiol-containing compound deficient conditions
US7790762B2 (en) * 2002-10-31 2010-09-07 National Jewish Health Compounds and methods for thiol-containing compound efflux and cancer treatment
US20080221029A1 (en) * 2002-10-31 2008-09-11 Regents Of The University Of Colorado Methods for treatment of thiol-containing compound deficient conditions
GB0228723D0 (en) * 2002-12-09 2003-01-15 Cambridge Biotechnology Ltd Treatment of pain
GB0305153D0 (en) * 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Identification of therapeutic compounds
DK2272503T3 (da) * 2003-03-28 2013-05-21 Ares Trading Sa Orale formuleringer af cladribin
EP1608343B1 (en) * 2003-03-28 2016-04-27 Ares Trading S.A. Cladribine formulations for improved oral and transmucosal delivery
UA81305C2 (en) 2003-07-02 2007-12-25 Ares Trading Sa Formulation of cladribine (variants), cladribine-cyclodextrin complex, use of cladribine-cyclodextrin complex, mixture
CA2530352A1 (en) * 2003-07-24 2005-02-03 Astellas Pharma Inc. Quinolone derivative or salt thereof
US20070167353A1 (en) * 2003-10-24 2007-07-19 John Hilfinger Prodrug composition
DK1699459T3 (da) * 2003-12-29 2007-10-08 Can Fite Biopharma Ltd Fremgangsmåde til behandling af multipel sclerose
CN1918178B (zh) 2004-01-12 2012-08-22 应用分子进化公司 Fc区变体
US20050277615A1 (en) * 2004-05-17 2005-12-15 Can-Fite Biopharma Ltd. Pharmaceutical compositions having anti-inflammatory activity
SI1835922T1 (sl) * 2004-12-22 2009-10-31 Merck Serono Sa Kombinacijsko zdravljenje multiple skleroze
SG160391A1 (en) * 2004-12-22 2010-04-29 Merck Serono Sa Cladribine regimen for treating multiple sclerosis
CA2595126A1 (en) 2005-01-14 2006-07-20 The Regents Of The University Of California Methods and compositions for preventing and treating a disease related to glycan dysregulation
US9925151B2 (en) 2006-05-24 2018-03-27 Merck Serono Sa Cladribine regimen for treating multiple sclerosis
US8126690B2 (en) * 2007-05-18 2012-02-28 The Regents Of The University Of Michigan Algorithms to predict clinical response, adherence, and shunting with thiopurines
US9526707B2 (en) * 2007-08-13 2016-12-27 Howard L. Elford Methods for treating or preventing neuroinflammation or autoimmune diseases
US8845627B2 (en) * 2008-08-22 2014-09-30 Boston Scientific Scimed, Inc. Regulating pressure to lower temperature in a cryotherapy balloon catheter
WO2010042933A2 (en) 2008-10-10 2010-04-15 Northwestern University Inhibition and treatment of prostate cancer metastasis
EP2343074A1 (en) 2009-12-23 2011-07-13 Merck Serono S.A. Use of purine analogues for treating airway diseases
WO2012022740A1 (en) 2010-08-18 2012-02-23 Merck Serono S.A. Combination treatment of multiple sclerosis
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
WO2014145152A2 (en) 2013-03-15 2014-09-18 Gpb Scientific, Llc On-chip microfluidic processing of particles
US10324011B2 (en) 2013-03-15 2019-06-18 The Trustees Of Princeton University Methods and devices for high throughput purification
GB201401465D0 (en) 2014-01-29 2014-03-12 Roach Arthur H Use of cladribine for treating autoimmune inflammatory disease
JP2017534627A (ja) 2014-11-06 2017-11-24 ノースウエスタン ユニバーシティＮｏｒｔｈｗｅｓｔｅｒｎ Ｕｎｉｖｅｒｓｉｔｙ 癌細胞運動性の阻害
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
EP3341893A4 (en) * 2015-08-24 2019-03-06 GPB Scientific, LLC METHODS AND DEVICES FOR PURIFICATION AND CONCENTRATION OF MULTI-STEP CELLS
GB2564717A (en) 2017-07-21 2019-01-23 Chord Therapeutics S A R L Use of cladribine for treating autoimmune neuromuscular disease
BR112020010282A2 (pt) 2017-11-24 2020-11-17 Merck Patent Gmbh regime de cladribina para uso no tratamento de formas progressivas de esclerose múltipla
JP2023541877A (ja) 2020-09-10 2023-10-04 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 自己免疫障害の処置のための新規の処置レジメン
GB2601786A (en) 2020-12-10 2022-06-15 Chord Therapeutics S A R L Use of cladribine for treating immune brain disease
EP4302091A1 (en) 2021-03-03 2024-01-10 Ares Trading S.A. Improved treatment methods using dmds for the treatment of autoimmune diseases, and biomarker for predicting and/or optimising said treatment methods

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DE1572068C3 (de) * 1966-03-12 1976-01-08 Hoechst Ag, 6000 Frankfurt Lichtempfindliche Schicht zur Herstellung von Druckformen
US3472838A (en) * 1967-12-01 1969-10-14 Parke Davis & Co 9 - (beta - d - arabinofuranosyl) - 6 - (amidino) purine compounds and methods for their production
US4826823A (en) * 1985-02-05 1989-05-02 Warner-Lambert Company Methods of using 2-chloro-2'-deoxyadenosine-5'-phosphate and its salts
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
US5310732A (en) * 1986-02-03 1994-05-10 The Scripps Research Institute 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
US5106837A (en) * 1988-03-16 1992-04-21 The Scripps Research Institute Adenosine derivatives with therapeutic activity
GB8708050D0 (en) * 1987-04-03 1987-05-07 Wellcome Found Therapeutic nucleosides
NZ226672A (en) * 1987-10-30 1991-07-26 Hoffmann La Roche 6-amino-9-(2,3-dideoxy-2-fluoro-b-d-threopentofuranosyl)-9h-purine derivatives and pharmaceutical compositions
GB8725466D0 (en) 1987-10-30 1987-12-02 Hoffmann La Roche Purine derivatives
US4968702A (en) * 1989-01-17 1990-11-06 American Cyanamid Company Substituted quinolinecarboxylic acids

Also Published As

Publication number Publication date
US5541164A (en) 1996-07-30
JP2688113B2 (ja) 1997-12-08
DE69328474D1 (de) 2000-05-31
WO1993016706A1 (en) 1993-09-02
DE69328474T2 (de) 2000-09-28
CA2130275C (en) 1999-06-29
HU9402392D0 (en) 1994-10-28
RU2130308C1 (ru) 1999-05-20
DK0626853T3 (da) 2000-08-07
EP0626853A1 (en) 1994-12-07
US5506214A (en) 1996-04-09
NO20000762L (no) 1994-09-13
ATE192045T1 (de) 2000-05-15
US5310732A (en) 1994-05-10
HUT68030A (en) 1995-05-29
NO942765L (no) 1994-09-13
US5506213A (en) 1996-04-09
JPH07507540A (ja) 1995-08-24
CH684310A5 (de) 1994-08-31
RU94038043A (ru) 1996-11-20
NO20000762D0 (no) 2000-02-16
NO942765D0 (no) 1994-07-25
HU218656B (hu) 2000-10-28
EP0626853B1 (en) 2000-04-26
FI943805A (fi) 1994-10-19
AU3724993A (en) 1993-09-13
BR9305907A (pt) 1997-10-21
NO309025B1 (no) 2000-12-04
NO322328B1 (no) 2006-09-18
CA2130275A1 (en) 1993-09-02
AU682818B2 (en) 1997-10-23

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