DK0626853T3 - Anvendelse af substituerede adeninderivater til behandling af multipel sclerose - Google Patents

Anvendelse af substituerede adeninderivater til behandling af multipel sclerose

Info

Publication number
DK0626853T3
DK0626853T3 DK93906071T DK93906071T DK0626853T3 DK 0626853 T3 DK0626853 T3 DK 0626853T3 DK 93906071 T DK93906071 T DK 93906071T DK 93906071 T DK93906071 T DK 93906071T DK 0626853 T3 DK0626853 T3 DK 0626853T3
Authority
DK
Denmark
Prior art keywords
multiple sclerosis
treatment
adenine derivatives
substituted adenine
formula
Prior art date
Application number
DK93906071T
Other languages
English (en)
Inventor
Ernest Beutler
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of DK0626853T3 publication Critical patent/DK0626853T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK93906071T 1992-02-19 1993-02-18 Anvendelse af substituerede adeninderivater til behandling af multipel sclerose DK0626853T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/838,546 US5310732A (en) 1986-02-03 1992-02-19 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
PCT/US1993/001467 WO1993016706A1 (en) 1992-02-19 1993-02-18 Use of substituted adenine derivatives for treating multiple sclerosis

Publications (1)

Publication Number Publication Date
DK0626853T3 true DK0626853T3 (da) 2000-08-07

Family

ID=25277387

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93906071T DK0626853T3 (da) 1992-02-19 1993-02-18 Anvendelse af substituerede adeninderivater til behandling af multipel sclerose

Country Status (15)

Country Link
US (4) US5310732A (da)
EP (1) EP0626853B1 (da)
JP (1) JP2688113B2 (da)
AT (1) ATE192045T1 (da)
AU (1) AU682818B2 (da)
BR (1) BR9305907A (da)
CA (1) CA2130275C (da)
CH (1) CH684310A5 (da)
DE (1) DE69328474T2 (da)
DK (1) DK0626853T3 (da)
FI (1) FI943805A (da)
HU (1) HU218656B (da)
NO (2) NO309025B1 (da)
RU (1) RU2130308C1 (da)
WO (1) WO1993016706A1 (da)

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US5672622A (en) * 1994-04-21 1997-09-30 Berlex Laboratories, Inc. Treatment of multiple sclerosis
US5773570A (en) * 1994-05-20 1998-06-30 The Regents Of The University Of California Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis
US7094597B1 (en) 1994-05-20 2006-08-22 The Regents Of The University Of California Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis
AU7470794A (en) * 1994-05-26 1995-12-21 Scripps Research Institute, The 2-halo-2'-deoxyadenosine treatement for inflammatory bowel disease
US6060501A (en) * 1994-06-02 2000-05-09 Schering Aktiengesellschaft Combined treatment of multiple sclerosis
US5817641A (en) * 1994-07-21 1998-10-06 Thomas Jefferson University Treatment of enterotoxigenic diarrhea with 2-substituted adenosine derivatives
US5510336A (en) * 1994-09-06 1996-04-23 Saven; Alan 2-halo-2'-deoxyadenosine treatment for histiocytosis
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US5811073A (en) * 1995-06-19 1998-09-22 President And Fellows Of Harvard College Method for radioisotopic detection and localization of inflammation in a host
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US6989377B2 (en) 1999-12-21 2006-01-24 Wisconsin Alumni Research Foundation Treating vitamin D responsive diseases
JP4555536B2 (ja) * 2000-02-18 2010-10-06 サザン・リサーチ・インスティテュート ２−クロロ−９−（２−デオキシ−２−フルオロ−β−Ｄ−アラビノフラノシル）−９Ｈ−プリン−６−アミンの合成方法
US7608683B2 (en) * 2000-08-09 2009-10-27 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
US6989146B2 (en) * 2000-08-09 2006-01-24 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
BR0115246A (pt) 2000-11-01 2005-04-26 Univ California Peptìdeos imunomoduladores derivados de proteìnas de choque e seu uso
WO2002078446A1 (en) * 2001-03-29 2002-10-10 Bioenergy Inc. Composition to reduce exercise-induced swelling of joints
US7528247B2 (en) * 2001-08-02 2009-05-05 Genzyme Corporation Process for preparing purine nucleosides
US7368423B1 (en) * 2001-12-05 2008-05-06 The Scripps Research Institute Composition and method for treating chronic allograft rejection
US20060100167A1 (en) * 2002-09-27 2006-05-11 Wood Christopher B Methods and compositions for the treatment of autoimmune disorders using clofarabine
CA2500091A1 (en) * 2002-09-27 2004-04-08 Bioenvision, Inc. Methods and compositions for the treatment of lupus using clofarabine
US20080221029A1 (en) * 2002-10-31 2008-09-11 Regents Of The University Of Colorado Methods for treatment of thiol-containing compound deficient conditions
US7790762B2 (en) * 2002-10-31 2010-09-07 National Jewish Health Compounds and methods for thiol-containing compound efflux and cancer treatment
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EA009714B1 (ru) * 2003-03-28 2008-02-28 Арес Трейдинг С.А. Препараты кладрибина для улучшенной пероральной доставки и доставки через слизистые оболочки
SG175450A1 (en) * 2003-03-28 2011-11-28 Ares Trading Sa Oral formulations of cladribine
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US20070167353A1 (en) * 2003-10-24 2007-07-19 John Hilfinger Prodrug composition
ES2287804T3 (es) * 2003-12-29 2007-12-16 Can-Fite Biopharma Ltd. Metodo para el tratamiento de esclerosis multiples.
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US20050277615A1 (en) * 2004-05-17 2005-12-15 Can-Fite Biopharma Ltd. Pharmaceutical compositions having anti-inflammatory activity
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US8658622B2 (en) * 2005-01-14 2014-02-25 Regents Of The University Of California Methods and compositions for preventing and treating a disease related to glycan dysregulation
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CN113512522A (zh) 2013-03-15 2021-10-19 普林斯顿大学理事会 用于高通量纯化的方法和设备
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
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US5310732A (en) * 1986-02-03 1994-05-10 The Scripps Research Institute 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis
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Also Published As

Publication number Publication date
CA2130275A1 (en) 1993-09-02
US5506213A (en) 1996-04-09
HU218656B (hu) 2000-10-28
NO322328B1 (no) 2006-09-18
WO1993016706A1 (en) 1993-09-02
NO309025B1 (no) 2000-12-04
NO942765L (no) 1994-09-13
FI943805A (fi) 1994-10-19
NO20000762L (no) 1994-09-13
AU3724993A (en) 1993-09-13
RU94038043A (ru) 1996-11-20
US5541164A (en) 1996-07-30
BR9305907A (pt) 1997-10-21
US5310732A (en) 1994-05-10
EP0626853B1 (en) 2000-04-26
FI943805A0 (fi) 1994-08-18
NO942765D0 (no) 1994-07-25
US5506214A (en) 1996-04-09
HU9402392D0 (en) 1994-10-28
EP0626853A1 (en) 1994-12-07
CH684310A5 (de) 1994-08-31
DE69328474D1 (de) 2000-05-31
AU682818B2 (en) 1997-10-23
RU2130308C1 (ru) 1999-05-20
CA2130275C (en) 1999-06-29
JP2688113B2 (ja) 1997-12-08
DE69328474T2 (de) 2000-09-28
NO20000762D0 (no) 2000-02-16
ATE192045T1 (de) 2000-05-15
HUT68030A (en) 1995-05-29
JPH07507540A (ja) 1995-08-24

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