BR0115246A - Peptìdeos imunomoduladores derivados de proteìnas de choque e seu uso - Google Patents
Peptìdeos imunomoduladores derivados de proteìnas de choque e seu usoInfo
- Publication number
- BR0115246A BR0115246A BR0115246-7A BR0115246A BR0115246A BR 0115246 A BR0115246 A BR 0115246A BR 0115246 A BR0115246 A BR 0115246A BR 0115246 A BR0115246 A BR 0115246A
- Authority
- BR
- Brazil
- Prior art keywords
- immune
- modulating
- inflammation
- homologous
- shock protein
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 230000035939 shock Effects 0.000 title abstract 2
- 230000002519 immonomodulatory effect Effects 0.000 title 1
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 230000028993 immune response Effects 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108020000946 Bacterial DNA Proteins 0.000 abstract 1
- 238000011238 DNA vaccination Methods 0.000 abstract 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000008102 immune modulation Effects 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 230000002584 immunomodulator Effects 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 230000028709 inflammatory response Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"PEPTìDEOS IMUNOMODULADORES DERIVADOS DE PROTEìNAS DE CHOQUE TéRMICO E SEU USO". A presente invenção refere-se a um método de modulação de uma resposta imune em um indivíduo. A invenção baseia-se na descoberta de que uma estratégia terapêutica eficaz para melhorar os sintomas relacionados com inflamação de uma doença imune-mediada, tal como artrite, pode ser alcançada mediante a modulação da resposta imune fundamental propriamente dita, em vez de simplesmente se voltar para a inflamação resultante. Esta estratégia pode ser usada para regular a resposta inflamatória e é aplicável a uma variedade de contextos em que a modulação imune é desejada, tal como tolerância da mucosa, vacinação de DNA, indução de energia, imunização ativa, e modulação ex vivo de células T específicas do antígeno. Em uma modalidade, o método compreende administrar ao indivíduo um peptídeo de dnaJ bacteriana ou uma isoforma humana homóloga ou não homóloga deste.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24518100P | 2000-11-01 | 2000-11-01 | |
| PCT/US2001/045344 WO2002036611A2 (en) | 2000-11-01 | 2001-10-31 | Immunomodulatory peptides derived from heat shock proteins and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0115246A true BR0115246A (pt) | 2005-04-26 |
Family
ID=22925623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0115246-7A BR0115246A (pt) | 2000-11-01 | 2001-10-31 | Peptìdeos imunomoduladores derivados de proteìnas de choque e seu uso |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7301005B2 (pt) |
| EP (1) | EP1355923B1 (pt) |
| JP (1) | JP4264257B2 (pt) |
| KR (1) | KR20030055295A (pt) |
| CN (1) | CN1481390B (pt) |
| AT (1) | ATE548376T1 (pt) |
| AU (1) | AU2002220038A1 (pt) |
| BR (1) | BR0115246A (pt) |
| CA (1) | CA2427572A1 (pt) |
| EA (1) | EA005821B1 (pt) |
| IL (1) | IL155610A0 (pt) |
| MX (1) | MXPA03003901A (pt) |
| WO (1) | WO2002036611A2 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006052654A2 (en) * | 2004-11-07 | 2006-05-18 | Androclus Therapeutics Inc. | Compositions and methods for the treatment of immune mediated diseases |
| WO2007140287A2 (en) * | 2006-05-25 | 2007-12-06 | Dr. Reddy's Laboratories, Inc. | Use of biomarkers of inflammation as indicators of drug efficacy |
| AT504685B1 (de) * | 2006-12-20 | 2009-01-15 | Protaffin Biotechnologie Ag | Fusionsproteine |
| JP2010532785A (ja) | 2007-07-06 | 2010-10-14 | ウニベルジテイト・ウトレヒト・ホールディング・ビー．ブイ． | 炎症性疾患および自己免疫疾患の治療および予防 |
| NZ702796A (en) * | 2010-07-26 | 2017-03-31 | Qu Biologics Inc | Immunogenic anti-inflammatory compositions |
| RU2483746C1 (ru) * | 2012-05-17 | 2013-06-10 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") | Средство для антиагрегатной, антивоспалительной и цитопротекторной терапии |
| KR101632948B1 (ko) * | 2014-05-13 | 2016-06-27 | (주)케어젠 | 항염증, 골 형성 및 발모 촉진 활성을 갖는 펩타이드 및 이의 용도 |
| AU2017271122B2 (en) | 2016-05-25 | 2023-10-26 | The Council Of The Queensland Institute Of Medical Research | Methods of immunotherapy |
| US11459575B2 (en) | 2018-02-09 | 2022-10-04 | Consejo Nacional De Investigaciones Científicas Y Técnicas (Conicet | Immunomodulating and immunostimulating ecotin polypeptides from Salmonella for drug-delivery |
| GB201807831D0 (en) * | 2018-05-15 | 2018-06-27 | Univ College Cardiff Consultants Ltd | Cancer Vaccine |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4732757A (en) | 1978-02-06 | 1988-03-22 | Stolle Research And Development Corporation | Prevention and treatment of rheumatoid arthritis |
| US4683295A (en) | 1984-05-24 | 1987-07-28 | Scripps Clinic And Research Foundation | Method for the preparation of anti-receptor antibodies |
| US5116725A (en) | 1984-08-08 | 1992-05-26 | Scripps Clinic And Research Foundation | Assay for Epstein-Barr virus infection with solid phase bound synthetic polypeptides |
| US4654419A (en) | 1984-08-08 | 1987-03-31 | Scripps Clinic And Research Foundation | Synthetic polypeptides and antibodies related to epstein-barr virus nuclear antigen |
| US5310732A (en) | 1986-02-03 | 1994-05-10 | The Scripps Research Institute | 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis |
| JPH05500653A (ja) | 1989-05-31 | 1993-02-12 | スクリプス クリニック アンド リサーチ ファウンデーション | リウマチ様関節炎の処置法 |
| WO1991001146A1 (en) * | 1989-07-14 | 1991-02-07 | Praxis Biologics, Inc. | Cytokine and hormone carriers for conjugate vaccines |
| US5891435A (en) | 1993-04-16 | 1999-04-06 | Research Corporation Technologies, Inc. | Methods and compositions for delaying or preventing the onset of autoimmune disease |
| US5728385A (en) | 1993-08-12 | 1998-03-17 | Classen Immunotherapies, Inc. | Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae |
| WO1995031984A1 (en) * | 1994-05-20 | 1995-11-30 | The Regents Of The University Of California | Method and reagents for the treatment of rheumatoid arthritis |
| US5773570A (en) * | 1994-05-20 | 1998-06-30 | The Regents Of The University Of California | Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis |
| US5993803A (en) | 1996-08-30 | 1999-11-30 | Yeda Research And Development Co., Ltd. | Method of reducing the severity of host vs graft reaction by down-regulating hsp60 autoimmunity |
| DE19702065C1 (de) * | 1997-01-22 | 1998-05-20 | Kurzik Dumke Ursula Dr | Polyklonaler Antikörper zum Nachweis des tumorassoziierten Antigens hTid |
| US6007821A (en) | 1997-10-16 | 1999-12-28 | Fordham University | Method and compositions for the treatment of autoimmune disease using heat shock proteins |
| US5992567A (en) | 1999-01-29 | 1999-11-30 | Chiu; Ping-Jan | Foldable frame |
-
2001
- 2001-10-31 WO PCT/US2001/045344 patent/WO2002036611A2/en active Application Filing
- 2001-10-31 AU AU2002220038A patent/AU2002220038A1/en not_active Abandoned
- 2001-10-31 IL IL15561001A patent/IL155610A0/xx unknown
- 2001-10-31 AT AT01992716T patent/ATE548376T1/de active
- 2001-10-31 KR KR10-2003-7006086A patent/KR20030055295A/ko not_active Application Discontinuation
- 2001-10-31 EA EA200300438A patent/EA005821B1/ru not_active IP Right Cessation
- 2001-10-31 JP JP2002539369A patent/JP4264257B2/ja not_active Expired - Fee Related
- 2001-10-31 US US10/001,938 patent/US7301005B2/en not_active Expired - Fee Related
- 2001-10-31 CA CA002427572A patent/CA2427572A1/en not_active Abandoned
- 2001-10-31 EP EP01992716A patent/EP1355923B1/en not_active Expired - Lifetime
- 2001-10-31 BR BR0115246-7A patent/BR0115246A/pt not_active IP Right Cessation
- 2001-10-31 MX MXPA03003901A patent/MXPA03003901A/es not_active Application Discontinuation
- 2001-10-31 CN CN018207642A patent/CN1481390B/zh not_active Expired - Fee Related
-
2007
- 2007-11-12 US US11/938,762 patent/US20080187550A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002036611A2 (en) | 2002-05-10 |
| JP4264257B2 (ja) | 2009-05-13 |
| IL155610A0 (en) | 2003-11-23 |
| MXPA03003901A (es) | 2004-09-10 |
| EP1355923B1 (en) | 2012-03-07 |
| US7301005B2 (en) | 2007-11-27 |
| KR20030055295A (ko) | 2003-07-02 |
| CN1481390A (zh) | 2004-03-10 |
| US20080187550A1 (en) | 2008-08-07 |
| EA200300438A1 (ru) | 2003-12-25 |
| JP2004537496A (ja) | 2004-12-16 |
| EA005821B1 (ru) | 2005-06-30 |
| US20030031679A1 (en) | 2003-02-13 |
| CN1481390B (zh) | 2010-12-22 |
| ATE548376T1 (de) | 2012-03-15 |
| WO2002036611A3 (en) | 2003-08-21 |
| CA2427572A1 (en) | 2002-05-10 |
| EP1355923A2 (en) | 2003-10-29 |
| AU2002220038A1 (en) | 2002-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2112 DE 28/06/2011. |