BR0308101A - Vacinas de dna que codificam cea e um ligante de cd40 e seus métodos de uso - Google Patents
Vacinas de dna que codificam cea e um ligante de cd40 e seus métodos de usoInfo
- Publication number
- BR0308101A BR0308101A BR0308101-0A BR0308101A BR0308101A BR 0308101 A BR0308101 A BR 0308101A BR 0308101 A BR0308101 A BR 0308101A BR 0308101 A BR0308101 A BR 0308101A
- Authority
- BR
- Brazil
- Prior art keywords
- cea
- dna
- immune response
- stimulate
- ligand
- Prior art date
Links
- 108010041986 DNA Vaccines Proteins 0.000 title abstract 4
- 229940021995 DNA vaccine Drugs 0.000 title abstract 4
- 239000003446 ligand Substances 0.000 title 1
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 abstract 4
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 abstract 4
- 230000028993 immune response Effects 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 108010029697 CD40 Ligand Proteins 0.000 abstract 1
- 101150013553 CD40 gene Proteins 0.000 abstract 1
- 102100032937 CD40 ligand Human genes 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000002238 attenuated effect Effects 0.000 abstract 1
- 208000029742 colonic neoplasm Diseases 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000005924 vaccine-induced immune response Effects 0.000 abstract 1
- 239000003981 vehicle Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00118—Cancer antigens from embryonic or fetal origin
- A61K39/001182—Carcinoembryonic antigen [CEA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55533—IL-2
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Developmental Biology & Embryology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
"VACINAS DE DNA QUE CODIFICAM CEA E UM LIGANTE DE CD40 E SEUS MéTODOS DE USO". Vacina de DNA eficaz para estimular uma resposta imune contra células que apresentam um antígeno carcinoembriónico (CEA) compreende um DNA que codifica operavelmente um CEA e um DNA que codifica operavelmente um ligante do CD40, SEQ ID NO: 1 e SEQ ID NO: 2, respectivamente, ou seu homotrímero CD4OLT. A vacina de DNA pode ser incorporada em um vetor de distribuição, tal como uma bactéria ou vírus vivos atenuados, ou veículo lipossómico. Em uma modalidade do método , a vacina de DNA é administrada oralmente a um mamífero, tal como um ser humano, para estimular uma resposta imune para estimular uma resposta imune contra células que apresentam CEA, tais como as células de câncer do cólon. Uma modalidade preferida do método inclui a etapa adicional de tratar o mamífero com proteína recombinante de fusão de anticorpo huKS-1/4-IL2 para intensificar a eficácia da resposta imune da vacina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/090,238 US6923958B2 (en) | 2002-03-02 | 2002-03-02 | DNA vaccines encoding CEA and a CD40 ligand and methods of use thereof |
PCT/US2003/006295 WO2003074712A1 (en) | 2002-03-02 | 2003-02-28 | Dna vaccines encoding cea and a cd40 ligand and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0308101A true BR0308101A (pt) | 2005-01-04 |
Family
ID=27787600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0308101-0A BR0308101A (pt) | 2002-03-02 | 2003-02-28 | Vacinas de dna que codificam cea e um ligante de cd40 e seus métodos de uso |
Country Status (13)
Country | Link |
---|---|
US (2) | US6923958B2 (pt) |
EP (1) | EP1487984A4 (pt) |
JP (1) | JP2005526750A (pt) |
KR (1) | KR20040089696A (pt) |
CN (1) | CN1650015A (pt) |
AU (1) | AU2003213653B2 (pt) |
BR (1) | BR0308101A (pt) |
CA (1) | CA2477647A1 (pt) |
MX (1) | MXPA04008475A (pt) |
PL (1) | PL373607A1 (pt) |
RU (1) | RU2004129331A (pt) |
WO (1) | WO2003074712A1 (pt) |
ZA (1) | ZA200406991B (pt) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101114784B1 (ko) | 2002-11-12 | 2012-02-27 | 예일 유니버시티 | 아데노바이러스 벡터 백신 |
CN104147597A (zh) * | 2002-12-16 | 2014-11-19 | 全球免疫股份有限公司 | 用于免疫治疗的基于酵母的疫苗 |
US8343502B2 (en) * | 2002-12-16 | 2013-01-01 | Globeimmune, Inc. | Yeast-based vaccines as immunotherapy |
JP4173024B2 (ja) * | 2003-02-14 | 2008-10-29 | 富士通メディアデバイス株式会社 | 電子部品の製造方法及びそのベース基板 |
CN100425290C (zh) * | 2003-10-30 | 2008-10-15 | 中山大学中山医学院科技开发中心 | 人cea基因疫苗、其构建方法及其在制备防治肿瘤疫苗中的应用 |
CA2544946A1 (en) * | 2003-11-24 | 2005-03-06 | Sidney Kimmel Cancer Center | Mucin antigen vaccine |
US20050287118A1 (en) * | 2003-11-26 | 2005-12-29 | Epitomics, Inc. | Bacterial plasmid with immunological adjuvant function and uses thereof |
US8828957B2 (en) * | 2003-12-11 | 2014-09-09 | Microvax, Llc | Methods for generating immunity to antigen |
JP2008504219A (ja) * | 2003-12-11 | 2008-02-14 | シドニー キンメル キャンサー センター | 抗原に対する免疫を生じさせる方法 |
WO2007053189A2 (en) * | 2005-06-01 | 2007-05-10 | Northwestern University | Compositions and methods for altering immune function |
WO2007103048A2 (en) * | 2006-03-01 | 2007-09-13 | Regents Of The University Of Colorado | Tlr agonist (flagellin)/cd40 agonist/antigen protein and dna conjugates and use thereof for inducing synergistic enhancement in immunity |
ES2520026T3 (es) | 2006-09-18 | 2014-11-11 | The Board Of Trustees Of The University Of Arkansas | Composiciones y métodos para potenciar respuestas inmunitarias |
GB0703976D0 (en) * | 2007-03-02 | 2007-04-11 | Adjuvantix Ltd | Liposome preparation |
BRPI0818736A2 (pt) * | 2007-10-30 | 2017-06-13 | Univ Arkansas | composições e métodos para intensificar imunorrepostas à bactéria flagelada |
ES2599905T3 (es) | 2007-11-01 | 2017-02-06 | The Board Of Trustees Of The University Of Arkansas | Composiciones y métodos para aumentar las respuestas inmunitarias a Eimeria |
WO2009062034A1 (en) * | 2007-11-07 | 2009-05-14 | Auburn University | Methods, compositions, and sequences of zp-binding peptides for immunocontraception of dogs and other animals |
WO2009126648A1 (en) | 2008-04-07 | 2009-10-15 | Auburn University | Zona pellucida binding peptides, expression vectors, compositions, and methods for species-specific immunocontraception of animals |
US20110236345A1 (en) * | 2008-07-03 | 2011-09-29 | Duke University | Composition and methods for eliciting an immune response |
NO2525817T3 (pt) | 2010-01-21 | 2018-01-06 | ||
WO2011119595A1 (en) | 2010-03-22 | 2011-09-29 | Auburn University | Phage constructs, sequences and antigenic compositions for immunocontraception of animals |
PT2579901T (pt) | 2010-06-09 | 2019-11-05 | Univ Arkansas | Vacina e métodos para reduzir infeção por campylobacter |
US20120156215A1 (en) | 2010-06-21 | 2012-06-21 | Auburn University | Phage-GnRH Constructs, Their Mimics, Antigenic Compositions, and Sequences for Immunocontraception of Animals and Other Applications |
US10973892B2 (en) | 2012-09-04 | 2021-04-13 | Bavarian Nordic A/S | Methods and compositions for enhancing vaccine immune responses |
EP2956165B1 (en) | 2013-02-14 | 2019-09-11 | The Board of Trustees of the University of Arkansas | Compositions and methods of enhancing immune responses to eimeria or limiting eimeria infection |
EP3578190A1 (en) | 2013-03-15 | 2019-12-11 | The Board of Trustees of the University of Arkansas | Compositions and methods of enhancing immune responses to enteric pathogens |
AU2014233114B2 (en) | 2013-03-15 | 2018-03-08 | Richard S. Kornbluth | Composition comprised of antigen linked to a TNF SuperFamily ligand |
MX2018013331A (es) | 2016-05-03 | 2019-06-10 | Univ Arkansas | Vector de vacuna de levadura que incluye polipeptidos inmunoestimuladores y antigenicos y metodos para su uso. |
WO2018189220A1 (en) * | 2017-04-13 | 2018-10-18 | F. Hoffmann-La Roche Ag | An interleukin-2 immunoconjugate, a cd40 agonist, and optionally a pd-1 axis binding antagonist for use in methods of treating cancer |
WO2021062037A1 (en) | 2019-09-24 | 2021-04-01 | Auburn University | Phage-peptide constructs for stimulation of an anti-cancer immune response against cd47 |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6214804B1 (en) | 1989-03-21 | 2001-04-10 | Vical Incorporated | Induction of a protective immune response in a mammal by injecting a DNA sequence |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US5641665A (en) | 1994-11-28 | 1997-06-24 | Vical Incorporated | Plasmids suitable for IL-2 expression |
US5741492A (en) | 1996-01-23 | 1998-04-21 | St. Jude Children's Research Hospital | Preparation and use of viral vectors for mixed envelope protein vaccines against human immunodeficiency viruses |
US5939400A (en) | 1996-02-26 | 1999-08-17 | The Board Of Trustees Of The Leland Stanford Junior University | DNA vaccination for induction of suppressive T cell response |
AU721729B2 (en) | 1996-05-01 | 2000-07-13 | Avant Immunotherapeutics, Inc. | Plasmid-based vaccine for treating atherosclerosis |
JP2002504380A (ja) * | 1998-02-27 | 2002-02-12 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | ワクチン、免疫療法剤およびそれらの使用法 |
ATE369428T1 (de) | 1998-09-04 | 2007-08-15 | Sanofi Pasteur Ltd | Behandlung von gebärmutterhalskrebs |
WO2002003961A1 (en) | 2000-07-07 | 2002-01-17 | Corixa Corporation | Microspheres and adjuvants for dna vaccine delivery |
-
2002
- 2002-03-02 US US10/090,238 patent/US6923958B2/en not_active Expired - Fee Related
-
2003
- 2003-02-28 CN CNA038099764A patent/CN1650015A/zh active Pending
- 2003-02-28 RU RU2004129331/13A patent/RU2004129331A/ru not_active Application Discontinuation
- 2003-02-28 WO PCT/US2003/006295 patent/WO2003074712A1/en active Application Filing
- 2003-02-28 MX MXPA04008475A patent/MXPA04008475A/es unknown
- 2003-02-28 JP JP2003573159A patent/JP2005526750A/ja not_active Withdrawn
- 2003-02-28 EP EP03711340A patent/EP1487984A4/en not_active Withdrawn
- 2003-02-28 BR BR0308101-0A patent/BR0308101A/pt not_active IP Right Cessation
- 2003-02-28 PL PL03373607A patent/PL373607A1/xx not_active Application Discontinuation
- 2003-02-28 KR KR10-2004-7013670A patent/KR20040089696A/ko not_active Application Discontinuation
- 2003-02-28 CA CA002477647A patent/CA2477647A1/en not_active Abandoned
- 2003-02-28 AU AU2003213653A patent/AU2003213653B2/en not_active Ceased
-
2004
- 2004-09-01 ZA ZA200406991A patent/ZA200406991B/en unknown
-
2005
- 2005-08-02 US US11/195,506 patent/US7279464B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20050287123A1 (en) | 2005-12-29 |
US7279464B2 (en) | 2007-10-09 |
WO2003074712A1 (en) | 2003-09-12 |
EP1487984A4 (en) | 2005-11-30 |
KR20040089696A (ko) | 2004-10-21 |
EP1487984A1 (en) | 2004-12-22 |
CA2477647A1 (en) | 2003-09-12 |
AU2003213653B2 (en) | 2007-11-15 |
US6923958B2 (en) | 2005-08-02 |
AU2003213653A1 (en) | 2003-09-16 |
MXPA04008475A (es) | 2004-12-06 |
JP2005526750A (ja) | 2005-09-08 |
US20030176377A1 (en) | 2003-09-18 |
PL373607A1 (en) | 2005-09-05 |
CN1650015A (zh) | 2005-08-03 |
RU2004129331A (ru) | 2005-04-20 |
ZA200406991B (en) | 2006-06-28 |
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A E 7A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010. |