DE60313437D1 - Mhc klasse i peptidepitope des humanen tumorassoziierten antigens 5t4 - Google Patents
Mhc klasse i peptidepitope des humanen tumorassoziierten antigens 5t4Info
- Publication number
- DE60313437D1 DE60313437D1 DE60313437T DE60313437T DE60313437D1 DE 60313437 D1 DE60313437 D1 DE 60313437D1 DE 60313437 T DE60313437 T DE 60313437T DE 60313437 T DE60313437 T DE 60313437T DE 60313437 D1 DE60313437 D1 DE 60313437D1
- Authority
- DE
- Germany
- Prior art keywords
- seq
- amino acid
- acid sequence
- sequence shown
- mhc class
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 102000043129 MHC class I family Human genes 0.000 abstract 1
- 108091054437 MHC class I family Proteins 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0203419.7A GB0203419D0 (en) | 2002-02-13 | 2002-02-13 | Peptide |
GB0203419 | 2002-02-13 | ||
PCT/GB2003/000670 WO2003068816A1 (en) | 2002-02-13 | 2003-02-13 | Mhc class i peptide epitopes from the human 5t4 tumor-associated antigen |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60313437D1 true DE60313437D1 (de) | 2007-06-06 |
DE60313437T2 DE60313437T2 (de) | 2008-01-03 |
Family
ID=9931004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60313437T Expired - Lifetime DE60313437T2 (de) | 2002-02-13 | 2003-02-13 | Mhc klasse i peptidepitope des humanen tumorassoziierten antigens 5t4 |
Country Status (9)
Country | Link |
---|---|
US (3) | US7575916B2 (de) |
EP (1) | EP1476463B1 (de) |
JP (1) | JP4533630B2 (de) |
AT (1) | ATE360642T1 (de) |
AU (1) | AU2003207321B2 (de) |
CA (1) | CA2476165A1 (de) |
DE (1) | DE60313437T2 (de) |
GB (1) | GB0203419D0 (de) |
WO (1) | WO2003068816A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0203419D0 (en) * | 2002-02-13 | 2002-04-03 | Oxford Biomedica Ltd | Peptide |
AU2003259913A1 (en) * | 2002-08-19 | 2004-03-03 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
DE10344799A1 (de) | 2003-09-26 | 2005-04-14 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
JP4926168B2 (ja) * | 2005-05-13 | 2012-05-09 | オックスフォード バイオメディカ(ユーケー)リミテッド | ペプチド |
GB0520067D0 (en) * | 2005-10-01 | 2005-11-09 | Cancer Rec Tech Ltd | Treatment of cancer |
WO2007062371A2 (en) * | 2005-11-23 | 2007-05-31 | University Of Maryland, Baltimore | Live vector vaccine and uses thereof |
AU2007226696C1 (en) * | 2006-03-10 | 2016-02-04 | Wyeth Llc | Anti-5T4 antibodies and uses thereof |
WO2008059252A2 (en) * | 2006-11-15 | 2008-05-22 | Oxford Biomedica (Uk) Limited | Methods and composition fro t cell receptors which recognize 5t4 antigen |
ES2535613T3 (es) | 2008-07-15 | 2015-05-13 | Oxford Biomedica (Uk) Limited | Método inmunoterapéutico |
GB201807932D0 (en) * | 2018-05-16 | 2018-06-27 | Redchenko Irina | Compositions and methods for inducing an immune response |
FR3119325B1 (fr) | 2021-01-29 | 2023-08-11 | Renault Jean Yves | Compositions liposomales orales |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0795954B2 (ja) | 1982-11-30 | 1995-10-18 | アメリカ合衆国 | 外来性遺伝子発現のためのポックスウイルス組換え体の製造方法 |
GB8305967D0 (en) | 1983-03-04 | 1983-04-07 | Univ Liverpool | Material for treatment of spontaneous abortions |
GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
WO1989001973A2 (en) * | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Recombinant pox virus for immunization against tumor-associated antigens |
US5869053A (en) | 1988-03-04 | 1999-02-09 | Cancer Research Campaign Technology, Ltd. | 5T4 antigen from human trophoblasts |
WO1989007947A1 (en) * | 1988-03-04 | 1989-09-08 | Cancer Research Campaign Technology Limited | Improvements relating to antigens |
US5118672A (en) | 1989-07-10 | 1992-06-02 | University Of Georgia Research Foundation | 5'-diphosphohexose nucleoside pharmaceutical compositions |
IL92629A0 (en) * | 1989-12-10 | 1990-08-31 | Yeda Res & Dev | Direct binding of t-cell epitopes to mhc gene products on intact living antigen presenting cells and the use thereof for identifying epitopes causing autoimmune diseases and pharmaceutical compositions for treating such diseases |
CA2089376C (en) | 1990-08-13 | 2010-05-04 | Phillip Dan Cook | Sugar modified oligonucleotides that detect and modulate gene expression |
WO2001000225A1 (en) | 1999-06-29 | 2001-01-04 | Epimmune Inc. | Hla binding peptides and their uses |
GB9523703D0 (en) | 1995-11-20 | 1996-01-24 | Wellcome Found | Enzyme prodrug thearapy |
NZ503318A (en) | 1997-09-23 | 2001-11-30 | Oxford Biomedica Ltd | Modified haemopoietic stem cell comprised of a spliced upstream with a nucleotide sequence of interest to be used as in gene therapy |
GB9720465D0 (en) | 1997-09-25 | 1997-11-26 | Oxford Biomedica Ltd | Dual-virus vectors |
EP2042598A1 (de) | 1998-11-18 | 2009-04-01 | Oxford Biomedica (UK) Limited | Verwendung vom Krebs-assoziierten Antigen 5T4 zur Immuntherapie |
GB2370573A (en) | 1998-11-18 | 2002-07-03 | Oxford Biomedica Ltd | Poxviral vectors |
WO2002038612A2 (en) | 2000-11-13 | 2002-05-16 | Oxford Biomedica (Uk) Limited | Canine and feline tumour-associated antigen 5t4 |
GB0203419D0 (en) * | 2002-02-13 | 2002-04-03 | Oxford Biomedica Ltd | Peptide |
-
2002
- 2002-02-13 GB GBGB0203419.7A patent/GB0203419D0/en not_active Ceased
-
2003
- 2003-02-13 US US10/504,602 patent/US7575916B2/en not_active Expired - Fee Related
- 2003-02-13 AU AU2003207321A patent/AU2003207321B2/en not_active Ceased
- 2003-02-13 AT AT03704793T patent/ATE360642T1/de active
- 2003-02-13 DE DE60313437T patent/DE60313437T2/de not_active Expired - Lifetime
- 2003-02-13 WO PCT/GB2003/000670 patent/WO2003068816A1/en active IP Right Grant
- 2003-02-13 EP EP03704793A patent/EP1476463B1/de not_active Expired - Lifetime
- 2003-02-13 JP JP2003567942A patent/JP4533630B2/ja not_active Expired - Fee Related
- 2003-02-13 CA CA002476165A patent/CA2476165A1/en not_active Abandoned
-
2009
- 2009-07-10 US US12/501,130 patent/US7888115B2/en not_active Expired - Fee Related
-
2011
- 2011-01-03 US US12/983,744 patent/US20110165668A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20110165668A1 (en) | 2011-07-07 |
GB0203419D0 (en) | 2002-04-03 |
JP2006500903A (ja) | 2006-01-12 |
US7888115B2 (en) | 2011-02-15 |
AU2003207321A1 (en) | 2003-09-04 |
EP1476463A1 (de) | 2004-11-17 |
US20100086995A1 (en) | 2010-04-08 |
AU2003207321B2 (en) | 2009-01-29 |
ATE360642T1 (de) | 2007-05-15 |
CA2476165A1 (en) | 2003-08-21 |
JP4533630B2 (ja) | 2010-09-01 |
WO2003068816A1 (en) | 2003-08-21 |
EP1476463B1 (de) | 2007-04-25 |
US20050123918A1 (en) | 2005-06-09 |
DE60313437T2 (de) | 2008-01-03 |
US7575916B2 (en) | 2009-08-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |