NO20021083L - Pyrazolo[4,3-d]pyrimidiner - Google Patents

Pyrazolo[4,3-d]pyrimidiner

Info

Publication number
NO20021083L
NO20021083L NO20021083A NO20021083A NO20021083L NO 20021083 L NO20021083 L NO 20021083L NO 20021083 A NO20021083 A NO 20021083A NO 20021083 A NO20021083 A NO 20021083A NO 20021083 L NO20021083 L NO 20021083L
Authority
NO
Norway
Prior art keywords
pyrazolo
pyrimidines
phosphodiesterase
inhibition
therapy
Prior art date
Application number
NO20021083A
Other languages
English (en)
Other versions
NO20021083D0 (no
Inventor
Rochus Jonas
Hans-Michael Eggenweiler
Pierre Schelling
Maria Christadler
Norbert Beier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO20021083L publication Critical patent/NO20021083L/no
Publication of NO20021083D0 publication Critical patent/NO20021083D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Abstract

Pyrazolo[4,3-d]pyrimidiner med formel 1 samt deres fysiologisk akseptable salter, hvor R1, R2, R3, R4 Og X har de i krav l angitte betydninger, utviser en fosfodiesterase V-inhibering og kan anvendes til behandling av sykdommer i hjerte-karsystemet og til behandling og/eller terapi av potensforstyrrelser.
NO20021083A 1999-09-06 2002-03-05 Pyrazolo[4,3-d]pyrimidiner NO20021083D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19942474A DE19942474A1 (de) 1999-09-06 1999-09-06 Pyrazolo[4,3-d]pyrimidine
PCT/EP2000/008257 WO2001018004A2 (de) 1999-09-06 2000-08-24 PYRAZOLO[4,3-d]PYRIMIDINE

Publications (2)

Publication Number Publication Date
NO20021083L true NO20021083L (no) 2002-03-05
NO20021083D0 NO20021083D0 (no) 2002-03-05

Family

ID=7920966

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021083A NO20021083D0 (no) 1999-09-06 2002-03-05 Pyrazolo[4,3-d]pyrimidiner

Country Status (23)

Country Link
US (1) US6777419B1 (no)
EP (1) EP1210349B1 (no)
JP (1) JP4975921B2 (no)
KR (1) KR20020025253A (no)
CN (1) CN1145627C (no)
AR (1) AR025569A1 (no)
AT (1) ATE231866T1 (no)
AU (1) AU773878B2 (no)
BR (1) BR0013781A (no)
CA (1) CA2384037C (no)
CZ (1) CZ294587B6 (no)
DE (2) DE19942474A1 (no)
DK (1) DK1210349T3 (no)
ES (1) ES2189766T3 (no)
HU (1) HUP0202624A3 (no)
MX (1) MXPA02002383A (no)
NO (1) NO20021083D0 (no)
PL (1) PL353366A1 (no)
PT (1) PT1210349E (no)
RU (1) RU2249594C2 (no)
SK (1) SK3132002A3 (no)
WO (1) WO2001018004A2 (no)
ZA (1) ZA200202653B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10031584A1 (de) 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
DE10058662A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Pyrazolo[4,3-d]pyrimidinen
JP2004516270A (ja) * 2000-12-19 2004-06-03 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング ピラゾロ〔４，３−ｄ〕ピリミジンおよび抗血栓剤、カルシウム拮抗剤、プロスタグランジンまたはプロスタグランジン誘導体を含む医薬製剤
DE10103647A1 (de) 2001-01-27 2002-08-01 Merck Patent Gmbh Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates
DE10148883A1 (de) 2001-10-04 2003-04-10 Merck Patent Gmbh Pyrimidinderivate
WO2004096810A1 (en) * 2003-04-29 2004-11-11 Pfizer Limited 5,7-diaminopyrazolo`4,3-d!pyrimidines useful in the treatment of hypertension
GB0327323D0 (en) * 2003-11-24 2003-12-31 Pfizer Ltd Novel pharmaceuticals
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
WO2005097799A1 (en) * 2004-04-07 2005-10-20 Pfizer Limited Pyrazolo`4,3-d! pyrimidines
US8227475B2 (en) 2005-05-12 2012-07-24 Pfizer Inc. Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide
NL2000291C2 (nl) 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
TWI606049B (zh) * 2011-04-21 2017-11-21 原真股份有限公司 新穎激酶抑制劑
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
HUE057202T2 (hu) 2017-12-14 2022-04-28 H Lundbeck As Kombinációs kezelések 1H-pirazolo[4,3-b]piridinek alkalmazásával
US10766893B2 (en) * 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
US11535611B2 (en) 2017-12-20 2022-12-27 H. Lundbeck A/S Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256650A (en) * 1989-03-29 1993-10-26 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
DE19644228A1 (de) * 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
PL336586A1 (en) 1997-04-25 2000-07-03 Pfizer Pyrazoylpyrimidinones inhibiting the cyclic guanosine 3',5'-monophosphate phosphodiesterase of type 5 (cgmp pde5) for treating sexual disorders
DE19752952A1 (de) * 1997-11-28 1999-06-02 Merck Patent Gmbh Thienopyrimidine
DE10031584A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
DE10058662A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Pyrazolo[4,3-d]pyrimidinen
DE10060388A1 (de) * 2000-12-05 2002-06-06 Merck Patent Gmbh Verwendung von Pyrazolo [4,3-d]pyrimidinen
DE10103647A1 (de) * 2001-01-27 2002-08-01 Merck Patent Gmbh Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates

Also Published As

Publication number Publication date
PT1210349E (pt) 2003-06-30
PL353366A1 (en) 2003-11-17
EP1210349A2 (de) 2002-06-05
CZ2002736A3 (cs) 2002-05-15
SK3132002A3 (en) 2002-07-02
CA2384037C (en) 2009-10-13
JP2003508534A (ja) 2003-03-04
CZ294587B6 (cs) 2005-02-16
RU2249594C2 (ru) 2005-04-10
CA2384037A1 (en) 2001-03-15
ES2189766T3 (es) 2003-07-16
KR20020025253A (ko) 2002-04-03
DE50001191D1 (de) 2003-03-06
JP4975921B2 (ja) 2012-07-11
WO2001018004A2 (de) 2001-03-15
MXPA02002383A (es) 2002-09-02
DK1210349T3 (da) 2003-05-19
AR025569A1 (es) 2002-12-04
BR0013781A (pt) 2002-05-14
ZA200202653B (en) 2003-09-23
AU7279300A (en) 2001-04-10
NO20021083D0 (no) 2002-03-05
EP1210349B1 (de) 2003-01-29
HUP0202624A2 (hu) 2002-12-28
HUP0202624A3 (en) 2004-11-29
US6777419B1 (en) 2004-08-17
CN1377357A (zh) 2002-10-30
CN1145627C (zh) 2004-04-14
WO2001018004A3 (de) 2001-08-09
DE19942474A1 (de) 2001-03-15
ATE231866T1 (de) 2003-02-15
AU773878B2 (en) 2004-06-10

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