NO20021083L - Pyrazolo[4,3-d]pyrimidiner - Google Patents

Pyrazolo[4,3-d]pyrimidiner

Info

Publication number
NO20021083L
NO20021083L NO20021083A NO20021083A NO20021083L NO 20021083 L NO20021083 L NO 20021083L NO 20021083 A NO20021083 A NO 20021083A NO 20021083 A NO20021083 A NO 20021083A NO 20021083 L NO20021083 L NO 20021083L
Authority
NO
Norway
Prior art keywords
pyrazolo
pyrimidines
phosphodiesterase
inhibition
therapy
Prior art date
Application number
NO20021083A
Other languages
English (en)
Other versions
NO20021083D0 (no
Inventor
Rochus Jonas
Hans-Michael Eggenweiler
Pierre Schelling
Maria Christadler
Norbert Beier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO20021083L publication Critical patent/NO20021083L/no
Publication of NO20021083D0 publication Critical patent/NO20021083D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Pyrazolo[4,3-d]pyrimidiner med formel 1 samt deres fysiologisk akseptable salter, hvor R1, R2, R3, R4 Og X har de i krav l angitte betydninger, utviser en fosfodiesterase V-inhibering og kan anvendes til behandling av sykdommer i hjerte-karsystemet og til behandling og/eller terapi av potensforstyrrelser.
NO20021083A 1999-09-06 2002-03-05 Pyrazolo[4,3-d]pyrimidiner NO20021083D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19942474A DE19942474A1 (de) 1999-09-06 1999-09-06 Pyrazolo[4,3-d]pyrimidine
PCT/EP2000/008257 WO2001018004A2 (de) 1999-09-06 2000-08-24 PYRAZOLO[4,3-d]PYRIMIDINE

Publications (2)

Publication Number Publication Date
NO20021083L true NO20021083L (no) 2002-03-05
NO20021083D0 NO20021083D0 (no) 2002-03-05

Family

ID=7920966

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021083A NO20021083D0 (no) 1999-09-06 2002-03-05 Pyrazolo[4,3-d]pyrimidiner

Country Status (23)

Country Link
US (1) US6777419B1 (no)
EP (1) EP1210349B1 (no)
JP (1) JP4975921B2 (no)
KR (1) KR20020025253A (no)
CN (1) CN1145627C (no)
AR (1) AR025569A1 (no)
AT (1) ATE231866T1 (no)
AU (1) AU773878B2 (no)
BR (1) BR0013781A (no)
CA (1) CA2384037C (no)
CZ (1) CZ294587B6 (no)
DE (2) DE19942474A1 (no)
DK (1) DK1210349T3 (no)
ES (1) ES2189766T3 (no)
HU (1) HUP0202624A3 (no)
MX (1) MXPA02002383A (no)
NO (1) NO20021083D0 (no)
PL (1) PL353366A1 (no)
PT (1) PT1210349E (no)
RU (1) RU2249594C2 (no)
SK (1) SK3132002A3 (no)
WO (1) WO2001018004A2 (no)
ZA (1) ZA200202653B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10031584A1 (de) 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
DE10058662A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Pyrazolo[4,3-d]pyrimidinen
BR0115995A (pt) * 2000-12-19 2004-01-13 Merck Patent Gmbh Formulação farmacêutica compreendendo pirazolo[4,3-d]pirimidinas e antitrombóticos, antagonistas de cálcio, prostaglandinas ou derivados de prostaglandina
DE10103647A1 (de) 2001-01-27 2002-08-01 Merck Patent Gmbh Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates
DE10148883A1 (de) * 2001-10-04 2003-04-10 Merck Patent Gmbh Pyrimidinderivate
DK1620437T3 (da) 2003-04-29 2009-08-24 Pfizer Ltd 5,7-diaminopyrazolo-4,3-d-pyrimidiner, der er anvendelige til behandling af hypertension
US7572799B2 (en) * 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
GB0327323D0 (en) * 2003-11-24 2003-12-31 Pfizer Ltd Novel pharmaceuticals
EP1742950B1 (en) * 2004-04-07 2008-12-17 Pfizer Limited Pyrazolo[4,3-d] pyrimidines
DK1881985T3 (da) 2005-05-12 2011-02-14 Pfizer Vandfrie krystalliske former af N-Y1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-D]pyrimidin-3-carbonyl¨methansulfonamid
NL2000291C2 (nl) 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
WO2012143144A1 (en) * 2011-04-21 2012-10-26 Origenis Gmbh Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
MX2020006174A (es) 2017-12-14 2022-09-27 H Lundbeck As Tratamientos de combinación que comprenden la administración de 1h-pirazol[4,3-b]piridinas.
CN111511742B (zh) 2017-12-20 2023-10-27 H.隆德贝克有限公司 作为PDE1抑制剂的吡唑并[4,3-b]吡啶和咪唑并[1,5-a]嘧啶
US10766893B2 (en) * 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256650A (en) * 1989-03-29 1993-10-26 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
DE19644228A1 (de) * 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
CZ299633B6 (cs) * 1997-04-25 2008-09-24 Pfizer Inc. Pyrazolopyrimidinony, meziprodukty pro jejich výrobu a farmaceutické a veterinární kompozice na jejich bázi
DE19752952A1 (de) * 1997-11-28 1999-06-02 Merck Patent Gmbh Thienopyrimidine
DE10031584A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
DE10058662A1 (de) * 2000-11-25 2002-05-29 Merck Patent Gmbh Verwendung von Pyrazolo[4,3-d]pyrimidinen
DE10060388A1 (de) * 2000-12-05 2002-06-06 Merck Patent Gmbh Verwendung von Pyrazolo [4,3-d]pyrimidinen
DE10103647A1 (de) * 2001-01-27 2002-08-01 Merck Patent Gmbh Verfahren zur Herstellung eines Pyrazolo (4,3-d) pyrimidinderivates

Also Published As

Publication number Publication date
MXPA02002383A (es) 2002-09-02
HUP0202624A2 (hu) 2002-12-28
WO2001018004A3 (de) 2001-08-09
EP1210349A2 (de) 2002-06-05
US6777419B1 (en) 2004-08-17
DE19942474A1 (de) 2001-03-15
DE50001191D1 (de) 2003-03-06
WO2001018004A2 (de) 2001-03-15
PL353366A1 (en) 2003-11-17
PT1210349E (pt) 2003-06-30
ES2189766T3 (es) 2003-07-16
BR0013781A (pt) 2002-05-14
CN1377357A (zh) 2002-10-30
CA2384037C (en) 2009-10-13
AU7279300A (en) 2001-04-10
ZA200202653B (en) 2003-09-23
EP1210349B1 (de) 2003-01-29
KR20020025253A (ko) 2002-04-03
CA2384037A1 (en) 2001-03-15
RU2249594C2 (ru) 2005-04-10
HUP0202624A3 (en) 2004-11-29
SK3132002A3 (en) 2002-07-02
AU773878B2 (en) 2004-06-10
ATE231866T1 (de) 2003-02-15
DK1210349T3 (da) 2003-05-19
JP2003508534A (ja) 2003-03-04
JP4975921B2 (ja) 2012-07-11
AR025569A1 (es) 2002-12-04
CN1145627C (zh) 2004-04-14
CZ2002736A3 (cs) 2002-05-15
CZ294587B6 (cs) 2005-02-16
NO20021083D0 (no) 2002-03-05

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