ZA971886B - Pyrimido[5,4-d]pyrimidines pharmaceuticals containing them their use and processes for the preparation thereof - Google Patents

Pyrimido[5,4-d]pyrimidines pharmaceuticals containing them their use and processes for the preparation thereof

Info

Publication number
ZA971886B
ZA971886B ZA971886A ZA971886A ZA971886B ZA 971886 B ZA971886 B ZA 971886B ZA 971886 A ZA971886 A ZA 971886A ZA 971886 A ZA971886 A ZA 971886A ZA 971886 B ZA971886 B ZA 971886B
Authority
ZA
South Africa
Prior art keywords
pyrimido
pyrimidines
processes
preparation
pharmaceuticals containing
Prior art date
Application number
ZA971886A
Other languages
English (en)
Inventor
Frank Himmelsbach
Georg Dahmann
Thomas Von Rueden
Thomas Metz
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of ZA971886B publication Critical patent/ZA971886B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
ZA971886A 1996-03-06 1997-03-05 Pyrimido[5,4-d]pyrimidines pharmaceuticals containing them their use and processes for the preparation thereof ZA971886B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19608653A DE19608653A1 (de) 1996-03-06 1996-03-06 Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ZA971886B true ZA971886B (en) 1998-09-07

Family

ID=7787391

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA971886A ZA971886B (en) 1996-03-06 1997-03-05 Pyrimido[5,4-d]pyrimidines pharmaceuticals containing them their use and processes for the preparation thereof

Country Status (23)

Country Link
US (1) US5977102A (xx)
EP (1) EP0885227A1 (xx)
JP (1) JP2000506153A (xx)
KR (1) KR19990087551A (xx)
CN (1) CN1212696A (xx)
AR (1) AR009937A1 (xx)
AU (1) AU712072B2 (xx)
BG (1) BG102790A (xx)
BR (1) BR9708004A (xx)
CA (1) CA2248316A1 (xx)
CO (1) CO4650044A1 (xx)
CZ (1) CZ281698A3 (xx)
DE (1) DE19608653A1 (xx)
EE (1) EE9800289A (xx)
HU (1) HUP9901750A2 (xx)
IL (1) IL125341A0 (xx)
NO (1) NO984081L (xx)
NZ (1) NZ331382A (xx)
PL (1) PL328776A1 (xx)
SK (1) SK120498A3 (xx)
TR (1) TR199801753T2 (xx)
WO (1) WO1997032882A1 (xx)
ZA (1) ZA971886B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0880508T1 (en) 1996-02-13 2003-10-31 Astrazeneca Ab Quinazoline derivatives as vegf inhibitors
ES2169355T3 (es) 1996-03-05 2002-07-01 Astrazeneca Ab Derivados de 4-anilinoquinazolina.
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
DE19911510A1 (de) * 1999-03-15 2000-09-21 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
NZ514477A (en) 1999-04-09 2003-04-29 Astrazeneca Ab Adamantane derivatives
WO2000069909A1 (en) 1999-05-14 2000-11-23 The United States Of America Through The Department Of Veterans Affairs Isolation and characterization of epidermal growth factor related protein
US7049410B2 (en) * 1999-05-14 2006-05-23 Majumdar Adhip P N Antibodies to a novel EGF-receptor related protein (ERRP)
ATE330954T1 (de) 1999-11-05 2006-07-15 Astrazeneca Ab Quinazolin-derivate als vegf-hemmer
SE9904505D0 (sv) 1999-12-09 1999-12-09 Astra Pharma Prod Novel compounds
TWI258462B (en) 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
WO2002024666A2 (en) * 2000-09-20 2002-03-28 Merck Patent Gmbh 4-amino-quinazolines
AU2001293817A1 (en) * 2000-09-20 2002-04-02 Merck Patent Gmbh 4-amino-quinazolines
PE20021011A1 (es) * 2001-03-23 2003-02-01 Bayer Corp Derivados quinazolinicos como inhibidores de la rho-quinasa
JP4320705B2 (ja) * 2001-03-23 2009-08-26 バイエル コーポレイション Ｒｈｏキナーゼ阻害剤
US7829566B2 (en) * 2001-09-17 2010-11-09 Werner Mederski 4-amino-quinazolines
US20040014755A1 (en) * 2002-01-10 2004-01-22 Dhanapalan Nagarathnam Rho-kinase inhibitors
US6924290B2 (en) * 2002-01-23 2005-08-02 Bayer Pharmaceuticals Corporation Rho-kinase inhibitors
JP4423043B2 (ja) * 2002-01-23 2010-03-03 バイエル ファーマセチカル コーポレーション Ｒｈｏ−キナーゼ阻害剤
KR101139038B1 (ko) * 2005-06-28 2012-05-02 삼성전자주식회사 피리미도피리미딘 유도체 및 이를 이용한 유기 박막 트랜지스터
AR073501A1 (es) * 2008-09-08 2010-11-10 Boehringer Ingelheim Int Derivados de pirimido[5,4-d]pirimidina inhibidores de la tirosinoquinasa
JP5603883B2 (ja) 2009-02-17 2014-10-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｂ−Ｒａｆキナーゼを阻害するためのピリミドピリミジン誘導体
CA2757368C (en) 2009-04-02 2019-03-12 Merck Patent Gmbh Piperidine and piperazine derivatives as autotaxin inhibitors
US20130023531A1 (en) 2011-01-27 2013-01-24 Boehringer Ingelheim International Gmbh Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors
WO2014175370A1 (ja) * 2013-04-25 2014-10-30 塩野義製薬株式会社 ピロリジン誘導体およびそれらを含有する医薬組成物
US10214520B2 (en) 2014-07-15 2019-02-26 Gruenenthal Gmbh Substituted azaspiro(4.5)decane derivatives
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3031450A (en) * 1959-04-30 1962-04-24 Thomae Gmbh Dr K Substituted pyrimido-[5, 4-d]-pyrimidines
EP0023559B1 (de) * 1979-07-03 1984-09-19 Dr. Karl Thomae GmbH 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidine, ihre Herstellung und diese Verbindungen enthaltenden Arzneimittel
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel
DE3423092A1 (de) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel
US5034393A (en) * 1989-07-27 1991-07-23 Dowelanco Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives
DE4325900A1 (de) * 1993-08-02 1995-02-09 Thomae Gmbh Dr K Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
DE4431867A1 (de) * 1994-09-07 1996-03-14 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
TW414798B (en) * 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation

Also Published As

Publication number Publication date
BR9708004A (pt) 1999-07-27
TR199801753T2 (xx) 1998-12-21
HUP9901750A2 (hu) 1999-09-28
WO1997032882A1 (de) 1997-09-12
NO984081D0 (no) 1998-09-04
PL328776A1 (en) 1999-02-15
JP2000506153A (ja) 2000-05-23
EE9800289A (et) 1999-02-15
AR009937A1 (es) 2000-05-17
BG102790A (bg) 1999-09-30
CA2248316A1 (en) 1997-09-12
EP0885227A1 (de) 1998-12-23
DE19608653A1 (de) 1997-09-11
AU712072B2 (en) 1999-10-28
SK120498A3 (en) 1999-04-13
KR19990087551A (ko) 1999-12-27
IL125341A0 (en) 1999-03-12
NO984081L (no) 1998-09-04
NZ331382A (en) 1999-08-30
CO4650044A1 (es) 1998-09-03
CN1212696A (zh) 1999-03-31
AU1925297A (en) 1997-09-22
US5977102A (en) 1999-11-02
CZ281698A3 (cs) 1999-02-17

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