TR200102505T2 - 4-amino-kinazolin ve kinolin türevleri. - Google Patents
4-amino-kinazolin ve kinolin türevleri.Info
- Publication number
- TR200102505T2 TR200102505T2 TR2001/02505T TR200102505T TR200102505T2 TR 200102505 T2 TR200102505 T2 TR 200102505T2 TR 2001/02505 T TR2001/02505 T TR 2001/02505T TR 200102505 T TR200102505 T TR 200102505T TR 200102505 T2 TR200102505 T2 TR 200102505T2
- Authority
- TR
- Turkey
- Prior art keywords
- quinazoline
- amino
- physiologically acceptable
- quinoline derivatives
- acceptable salts
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Mevcut bulus, Ra ila Rd'nin A ila G ve X'in istem 1'de tanimlandigi gibi oldugu genel formül (I)'e ait bisiklik heterosikleler, bunlarin tatomerleri, stereoizomerleri ve tuzlari, özellikle bunlarin fizyolojik açidan kabul gören tuzlari, özellikle bunlarin degerli farmakolojik özellikler gösteren inorganik veya organik asitlere sahip fizyolojik açidan kabul gören tuzlari, özellikle tirozin kinazlarin neden oldugu sinyal iletimi üzerindeki önleyici bir etki ile, bunlarin hastaliklarin, özellikle tümöral hastaliklarin, akcigerlerdeki ve solunum sistemindeki hastaliklarin tedavisinde kullanilmalariyla ve bunlarin preparasyonuyla ilgilidir. (Formül(I)).
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1999108567 DE19908567A1 (de) | 1999-02-27 | 1999-02-27 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE1999111366 DE19911366A1 (de) | 1999-03-15 | 1999-03-15 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE1999128306 DE19928306A1 (de) | 1999-06-21 | 1999-06-21 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
US14932999P | 1999-08-17 | 1999-08-17 | |
DE19954816A DE19954816A1 (de) | 1999-11-13 | 1999-11-13 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200102505T2 true TR200102505T2 (tr) | 2003-01-21 |
Family
ID=27512681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/02505T TR200102505T2 (tr) | 1999-02-27 | 2000-02-24 | 4-amino-kinazolin ve kinolin türevleri. |
Country Status (21)
Country | Link |
---|---|
US (1) | US6972288B1 (tr) |
EP (2) | EP1157011A1 (tr) |
JP (1) | JP3751201B2 (tr) |
KR (1) | KR20020068261A (tr) |
CN (1) | CN1341104A (tr) |
AU (1) | AU3281600A (tr) |
BG (1) | BG105765A (tr) |
BR (1) | BR0008524A (tr) |
CA (1) | CA2361174C (tr) |
CZ (1) | CZ20013079A3 (tr) |
EE (1) | EE200100449A (tr) |
HR (1) | HRP20010617A2 (tr) |
HU (1) | HUP0301132A3 (tr) |
ID (1) | ID29800A (tr) |
IL (1) | IL144143A0 (tr) |
NO (1) | NO20014114L (tr) |
NZ (1) | NZ513802A (tr) |
PL (1) | PL351619A1 (tr) |
SK (1) | SK12112001A3 (tr) |
TR (1) | TR200102505T2 (tr) |
WO (1) | WO2000051991A1 (tr) |
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US6846799B1 (en) * | 1998-08-18 | 2005-01-25 | The Regents Of The University Of California | Preventing airway mucus production by administration of EGF-R antagonists |
US6297258B1 (en) * | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
PT1731511E (pt) * | 1999-06-21 | 2015-11-13 | Boehringer Ingelheim Pharma | Heterociclos bicíclicos, medicamentos contendo estes compostos, a sua utilização e processos para a sua preparação |
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DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
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GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
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US6740651B2 (en) * | 2000-08-26 | 2004-05-25 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
-
2000
- 2000-02-24 BR BR0008524-3A patent/BR0008524A/pt not_active Expired - Fee Related
- 2000-02-24 AU AU32816/00A patent/AU3281600A/en not_active Abandoned
- 2000-02-24 WO PCT/EP2000/001496 patent/WO2000051991A1/en not_active Application Discontinuation
- 2000-02-24 JP JP2000602218A patent/JP3751201B2/ja not_active Expired - Fee Related
- 2000-02-24 HU HU0301132A patent/HUP0301132A3/hu unknown
- 2000-02-24 ID IDW00200101847A patent/ID29800A/id unknown
- 2000-02-24 EE EEP200100449A patent/EE200100449A/xx unknown
- 2000-02-24 SK SK1211-2001A patent/SK12112001A3/sk unknown
- 2000-02-24 IL IL14414300A patent/IL144143A0/xx unknown
- 2000-02-24 KR KR1020017010981A patent/KR20020068261A/ko not_active Application Discontinuation
- 2000-02-24 CA CA002361174A patent/CA2361174C/en not_active Expired - Lifetime
- 2000-02-24 US US09/914,323 patent/US6972288B1/en not_active Expired - Lifetime
- 2000-02-24 EP EP00910695A patent/EP1157011A1/en not_active Withdrawn
- 2000-02-24 NZ NZ513802A patent/NZ513802A/xx not_active Application Discontinuation
- 2000-02-24 TR TR2001/02505T patent/TR200102505T2/tr unknown
- 2000-02-24 CN CN00804215A patent/CN1341104A/zh active Pending
- 2000-02-24 EP EP10181231A patent/EP2298746A1/en not_active Withdrawn
- 2000-02-24 PL PL00351619A patent/PL351619A1/xx not_active Application Discontinuation
- 2000-02-24 CZ CZ20013079A patent/CZ20013079A3/cs unknown
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2001
- 2001-08-01 BG BG105765A patent/BG105765A/xx active Pending
- 2001-08-23 HR HR20010617A patent/HRP20010617A2/hr not_active Application Discontinuation
- 2001-08-24 NO NO20014114A patent/NO20014114L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU3281600A (en) | 2000-09-21 |
KR20020068261A (ko) | 2002-08-27 |
CZ20013079A3 (cs) | 2001-11-14 |
CA2361174C (en) | 2009-10-27 |
JP2002538145A (ja) | 2002-11-12 |
PL351619A1 (en) | 2003-05-19 |
CN1341104A (zh) | 2002-03-20 |
SK12112001A3 (sk) | 2001-12-03 |
BG105765A (en) | 2002-03-29 |
CA2361174A1 (en) | 2000-09-08 |
JP3751201B2 (ja) | 2006-03-01 |
HRP20010617A2 (en) | 2002-10-31 |
NO20014114D0 (no) | 2001-08-24 |
NO20014114L (no) | 2001-10-15 |
EP1157011A1 (en) | 2001-11-28 |
US6972288B1 (en) | 2005-12-06 |
EE200100449A (et) | 2002-12-16 |
HUP0301132A3 (en) | 2004-03-29 |
HUP0301132A2 (hu) | 2003-12-29 |
WO2000051991A1 (en) | 2000-09-08 |
NZ513802A (en) | 2001-09-28 |
ID29800A (id) | 2001-10-11 |
EP2298746A1 (en) | 2011-03-23 |
BR0008524A (pt) | 2001-12-18 |
IL144143A0 (en) | 2002-05-23 |
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