AR002950A1 - Derivados de la piperazina, sus sales aceptables desde el punto de vista fisiologico, un procedimiento para su preparacion y medicamentos que contienenestos compuestos. - Google Patents
Derivados de la piperazina, sus sales aceptables desde el punto de vista fisiologico, un procedimiento para su preparacion y medicamentos que contienenestos compuestos.Info
- Publication number
- AR002950A1 AR002950A1 ARP950100727A AR10072795A AR002950A1 AR 002950 A1 AR002950 A1 AR 002950A1 AR P950100727 A ARP950100727 A AR P950100727A AR 10072795 A AR10072795 A AR 10072795A AR 002950 A1 AR002950 A1 AR 002950A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- derivatives
- acceptable salts
- piperazine
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente invención se refiere a los derivados de la piperazina de fórmula general (I), en la que Ra representa un grupo de 3-pirrolidinilo, 3-piperidinilo, 4-piperidinilo, 3-hexametileniminilo o 4-hexametileniminilo, Rb y Rc que pueden ser iguales o diferentes, representan átomos de H, grupos dealquilo C1-5, arilo o aril-alquilo C1-5, ó Rb y Rc junto con el puente de etileno situado entre ellos, representan un grupo de o-fenileno;Y1 representaun grupo -A1-, -CO-, -CO-CO-, -A1-CO-, -C0-A1-, -S02-A2-, -A2-SO2-, -CO-A1-CO-, -CO-NR1-CO-,-CO-NR1-A2-, -CO-NR1-A2-C0-,-CO-A2-NR1-CO-, -CO-A2-O ó -CO-A2-NR1-;Y2 representa un grupo de fenileno, ciclohexileno o piridinileno, un grupo 3- piperidinileno, 4-piperidinileno o 1,4-piperazinileno; Y3 representa un grupo-CO-, -A2-CO-, -CH2-CH(NHR2)-CO-, NR2-A3-CO-, -CH2-NR2-A3-CO-, -O-A3-CO-, -CO-A3-CO- ó -CO-NR1-A3-CO-; y E representa un grupo hidroxi, un grupo alcoxicon 1 a 6 átomos de carbono, un grupo de fenilalcoxi, un grupode cicloalcoxi con 3 a 9 átomos de C, un grupo de cicloalcoxi con 5 a 8 átomos de C, un grupode cicloalqueniloxi, un grupo de alqueniloxi, fenilalqueniloxi, alquiniloxi, un grupo de cicloalquilalcoxi, un grupo de bicicloalcoxi, un grupo de 1,3-dihidro-3-oxo-1-isobenzofuraniloxi o un grupo R5-CO-O-(R3CR4)-O,ó E representa un grupo alfa-amino de un aminoácido natural, y sus ésteres, sus tautómeros,sus estereoisómeros, incluidas sus mezclas, y sus sales, en particular, sus sales aceptables desde el punto de vista fisiológico, La invención también serefiere a un procedimiento para preparar estos derivados y a los medicamentos que los contienen. Los nuevos compuestos presentan valiosas propiedadesfarmacológicas, en particular, efectos inhibidores de la agregación.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19944446301 DE4446301A1 (de) | 1994-12-23 | 1994-12-23 | Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE19526678A DE19526678A1 (de) | 1994-12-23 | 1995-07-21 | Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| DE1995133639 DE19533639A1 (de) | 1994-12-23 | 1995-09-12 | Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR002950A1 true AR002950A1 (es) | 1998-05-27 |
Family
ID=27207101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP950100727A AR002950A1 (es) | 1994-12-23 | 1995-12-22 | Derivados de la piperazina, sus sales aceptables desde el punto de vista fisiologico, un procedimiento para su preparacion y medicamentos que contienenestos compuestos. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5922717A (es) |
| EP (1) | EP0799202A1 (es) |
| JP (1) | JPH10511374A (es) |
| CN (1) | CN1183770A (es) |
| AR (1) | AR002950A1 (es) |
| AU (1) | AU4432496A (es) |
| BG (1) | BG101582A (es) |
| BR (1) | BR9510360A (es) |
| CA (1) | CA2207618A1 (es) |
| CZ (1) | CZ189197A3 (es) |
| EE (1) | EE9700141A (es) |
| FI (1) | FI972646A (es) |
| HR (1) | HRP950609A2 (es) |
| IL (1) | IL116517A0 (es) |
| MX (1) | MX9704745A (es) |
| NO (1) | NO972881L (es) |
| PL (1) | PL321003A1 (es) |
| SK (1) | SK79797A3 (es) |
| TR (1) | TR199501634A2 (es) |
| WO (1) | WO1996020173A1 (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037343A (en) * | 1994-12-22 | 2000-03-14 | Smithkline Beecham Corporation | Fibrinogen receptor antagonists |
| US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
| JPH11513382A (ja) * | 1995-10-20 | 1999-11-16 | ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ５員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法 |
| UY25225A1 (es) | 1997-10-29 | 2000-12-29 | Smithkline Beecham Plc | Derivados de pleuromutilina utiles como agentes antimicrobianos |
| EP1070712A4 (en) * | 1998-04-09 | 2005-01-05 | Meiji Seika Kaisha | NITROGEN-CONTAINING HETEROCYCLES WITH ANTI-BLOOD INFLAMMATION AND THEIR MEDICAL USE |
| CZ20011872A3 (cs) * | 1999-09-29 | 2002-03-13 | Ortho-Mcneil Pharmaceutical, Inc. | Isonipekotamidy pro léčbu onemocnění zprostředkovaných integriny |
| EP1533310A1 (en) * | 1999-09-29 | 2005-05-25 | Ortho-McNeil Pharmaceutical, Inc. | Isonipecotamides for the treatment of integrin-mediated disorders |
| USRE39921E1 (en) | 1999-10-07 | 2007-11-13 | Smithkline Beecham Corporation | Chemical compounds |
| GB9923748D0 (en) | 1999-10-07 | 1999-12-08 | Glaxo Group Ltd | Chemical compounds |
| GB0025354D0 (en) | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
| JP2004529918A (ja) * | 2001-04-09 | 2004-09-30 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | インテグリンに由来する疾患の治療のためのキナゾリンおよびキナゾリン類似化合物 |
| ATE530184T1 (de) | 2001-08-24 | 2011-11-15 | Univ Yale | Piperazinon-verbindungen als tumor- und krebsbekämpfende wirkstoffe |
| FR2829766A1 (fr) * | 2001-09-14 | 2003-03-21 | Lipha | Derives d'oxamates comportant un heterocycle azote diversement substitue |
| EP1472222A1 (en) | 2002-02-08 | 2004-11-03 | Glaxo Group Limited | Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases |
| GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
| GB0203022D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
| KR20070004769A (ko) * | 2004-02-27 | 2007-01-09 | 암젠 인코포레이션 | 대사 장애의 치료에 사용되는 화합물, 약제학적 조성물 및그 사용방법 |
| WO2007016496A2 (en) * | 2005-08-02 | 2007-02-08 | Neurogen Corporation | Dipiperazinyl ketones and related analogues |
| EP1942893A4 (en) * | 2005-10-28 | 2011-10-12 | Merck Sharp & Dohme | PIPERIDINE Glycine-TRANSPORTER INHIBITORS |
| PL2041088T3 (pl) | 2006-06-28 | 2014-07-31 | Amgen Inc | Inhibitory transportera-1 glicyny |
| US9090604B2 (en) | 2006-07-27 | 2015-07-28 | E I Du Pont De Nemours And Company | Fungicidal azocyclic amides |
| WO2008013622A2 (en) * | 2006-07-27 | 2008-01-31 | E. I. Du Pont De Nemours And Company | Fungicidal azocyclic amides |
| KR101227072B1 (ko) * | 2007-01-16 | 2013-01-29 | 시오노기세이야쿠가부시키가이샤 | Ｏｒｌ-1 리간드로서의 헤테로시클릭-치환 피페리딘 |
| MX2010002449A (es) | 2007-08-31 | 2010-09-07 | Purdue Pharma Lp | Compuestos de piperidina tipo quinoxalina sustituida y uso de los mismsos. |
| WO2010081851A1 (en) | 2009-01-14 | 2010-07-22 | Genoscience Pharma | Piperidin-4-ylpiperazine compounds for the treatment of hcv infection |
| JP2014527511A (ja) | 2011-06-24 | 2014-10-16 | アムジエン・インコーポレーテツド | Ｔｒｐｍ８拮抗剤及び治療におけるそれらの使用 |
| WO2012177896A1 (en) | 2011-06-24 | 2012-12-27 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
| CN104334541A (zh) | 2012-02-16 | 2015-02-04 | 纽约大学 | 使用低聚氧代哌嗪非肽螺旋模拟物对低氧诱导基因表达的控制 |
| US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
| AU2014207311A1 (en) | 2013-01-19 | 2015-08-20 | New York University | Oligooxopiperazines for p53 reactivation |
| WO2015179547A2 (en) | 2014-05-21 | 2015-11-26 | New York University | Oxopiperazine helix mimetics for control of hypoxia-inducible gene expression |
| WO2023122481A2 (en) * | 2021-12-20 | 2023-06-29 | Sigma-Aldrich Co. Llc | Chemical linkers |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2926472A1 (de) * | 1979-06-30 | 1981-01-15 | Thomae Gmbh Dr K | Neue benzoylderivate, deren herstellung und deren verwendung als arzneimittel |
| ZA825719B (en) * | 1981-09-03 | 1983-06-29 | Recordati Chem Pharm | Alkanoylanilides |
| PH19166A (en) * | 1982-09-04 | 1986-01-16 | Pfizer | Dihydropyridined,pharmaceutical compositions and method of use |
| US4895846A (en) * | 1984-04-11 | 1990-01-23 | Bristol-Myers Company | Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moieties |
| US4778796A (en) * | 1985-07-19 | 1988-10-18 | Dainippon Pharmaceutical Co., Ltd. | ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same |
| DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE4213919A1 (de) * | 1992-04-28 | 1993-11-04 | Thomae Gmbh Dr K | Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE4332168A1 (de) * | 1993-02-22 | 1995-03-23 | Thomae Gmbh Dr K | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| AU692439B2 (en) * | 1993-03-29 | 1998-06-11 | Zeneca Limited | Heterocyclic compounds as platelet aggregation inhibitors |
| ATE202345T1 (de) * | 1993-03-29 | 2001-07-15 | Astrazeneca Ab | Heterozyklische derivate als plätchenaggregationsinhibitoren |
| DE4324580A1 (de) * | 1993-07-22 | 1995-01-26 | Thomae Gmbh Dr K | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| DE4326344A1 (de) * | 1993-08-05 | 1995-02-09 | Thomae Gmbh Dr K | Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| TW397831B (en) * | 1994-07-15 | 2000-07-11 | Meiji Seika Kaisha | The anti-platelet-agglutination hexahydrogenated pyridine and its derivatives |
| IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
-
1995
- 1995-12-19 SK SK797-97A patent/SK79797A3/sk unknown
- 1995-12-19 CN CN95196854A patent/CN1183770A/zh active Pending
- 1995-12-19 CA CA002207618A patent/CA2207618A1/en not_active Abandoned
- 1995-12-19 JP JP8520188A patent/JPH10511374A/ja active Pending
- 1995-12-19 AU AU44324/96A patent/AU4432496A/en not_active Abandoned
- 1995-12-19 EE EE9700141A patent/EE9700141A/xx unknown
- 1995-12-19 BR BR9510360A patent/BR9510360A/pt not_active Application Discontinuation
- 1995-12-19 CZ CZ971891A patent/CZ189197A3/cs unknown
- 1995-12-19 PL PL95321003A patent/PL321003A1/xx unknown
- 1995-12-19 EP EP95943168A patent/EP0799202A1/de not_active Withdrawn
- 1995-12-19 WO PCT/EP1995/005031 patent/WO1996020173A1/de not_active Application Discontinuation
- 1995-12-19 MX MX9704745A patent/MX9704745A/es unknown
- 1995-12-20 HR HR19533639.9A patent/HRP950609A2/hr not_active Application Discontinuation
- 1995-12-21 TR TR95/01634A patent/TR199501634A2/xx unknown
- 1995-12-21 US US08/576,528 patent/US5922717A/en not_active Expired - Fee Related
- 1995-12-22 AR ARP950100727A patent/AR002950A1/es unknown
- 1995-12-22 IL IL11651795A patent/IL116517A0/xx unknown
-
1997
- 1997-06-06 BG BG101582A patent/BG101582A/xx unknown
- 1997-06-19 FI FI972646A patent/FI972646A/fi not_active Application Discontinuation
- 1997-06-20 NO NO972881A patent/NO972881L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI972646A0 (fi) | 1997-06-19 |
| JPH10511374A (ja) | 1998-11-04 |
| NO972881D0 (no) | 1997-06-20 |
| EP0799202A1 (de) | 1997-10-08 |
| US5922717A (en) | 1999-07-13 |
| SK79797A3 (en) | 1997-11-05 |
| CN1183770A (zh) | 1998-06-03 |
| BR9510360A (pt) | 1997-12-23 |
| TR199501634A2 (tr) | 1996-07-21 |
| HRP950609A2 (en) | 1997-10-31 |
| CZ189197A3 (cs) | 1998-01-14 |
| AU4432496A (en) | 1996-07-19 |
| EE9700141A (et) | 1997-12-15 |
| CA2207618A1 (en) | 1996-07-04 |
| MX9704745A (es) | 1997-10-31 |
| NO972881L (no) | 1997-06-20 |
| FI972646A (fi) | 1997-08-19 |
| WO1996020173A1 (de) | 1996-07-04 |
| IL116517A0 (en) | 1996-03-31 |
| PL321003A1 (en) | 1997-11-24 |
| BG101582A (en) | 1998-01-30 |
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