AR006690A1 - Piperidinas y pirrolidinas, procedimiento para prepararlas, preparaciones farmaceuticas que las contienen y procedimiento para preparar estaspreparaciones farmaceuticas. - Google Patents

Piperidinas y pirrolidinas, procedimiento para prepararlas, preparaciones farmaceuticas que las contienen y procedimiento para preparar estaspreparaciones farmaceuticas.

Info

Publication number
AR006690A1
AR006690A1 ARP970101562A ARP970101562A AR006690A1 AR 006690 A1 AR006690 A1 AR 006690A1 AR P970101562 A ARP970101562 A AR P970101562A AR P970101562 A ARP970101562 A AR P970101562A AR 006690 A1 AR006690 A1 AR 006690A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical preparations
prepare
procedure
hal
mono
Prior art date
Application number
ARP970101562A
Other languages
English (en)
Original Assignee
Merck Patent Ges Mit Beschränkter Haftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Ges Mit Beschränkter Haftung filed Critical Merck Patent Ges Mit Beschränkter Haftung
Publication of AR006690A1 publication Critical patent/AR006690A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Derivados de la piperidina y pirrolidina de fórmula (I), en donde: R1 es fenilo no sustituido, o bien mono-, di o trisustituido con A, A-O-, Hal, CN,NO2, NH2, Ph,-O-SO2A y/o -O-SO2CF3, 2- o 3-indolilo no sustituido, o bien mono o disustituido con A, A-O-, OH, Hal y/o CN, 1,4-benzodioxan-5- o 6-ilo, o1- o 2-naftilo; R2 es fenilo o piridilo no sustituido, o bien mono o disustituido con A, A-O, OH, Hal y/o CN; R3 es H, A, A-O-, Ph, NHR4 o NR5R6;k, l son independientemente 0 o1; m es 0, 1 o 2 y n es 1 o 2 o sus sales y productos intermedios. También se refiere a un procedimiento para prepararestos compuestos y sus sales aceptables desde el punto de vista fisiológico, a preparaciones farmacéuticas que los contieneny al empleo de los mismospara combatir los trastornos alimenticios, trastornos en el aprendizaje, los trastornos de la memoria dependientes de la edad, la discinesia taría y paraejercer una influencia positiva sobre el comportamiento en situaciones de tensión. Los compuestos de fórmula (I) presentan una acción antagonista dereceptor 5-HT1A e inhiben la reabsorción de 5-HT. Estos compuestos pueden ser empleados para preparar medicamentos.
ARP970101562A 1996-04-18 1997-04-18 Piperidinas y pirrolidinas, procedimiento para prepararlas, preparaciones farmaceuticas que las contienen y procedimiento para preparar estaspreparaciones farmaceuticas. AR006690A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19615232A DE19615232A1 (de) 1996-04-18 1996-04-18 Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten

Publications (1)

Publication Number Publication Date
AR006690A1 true AR006690A1 (es) 1999-09-08

Family

ID=7791576

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970101562A AR006690A1 (es) 1996-04-18 1997-04-18 Piperidinas y pirrolidinas, procedimiento para prepararlas, preparaciones farmaceuticas que las contienen y procedimiento para preparar estaspreparaciones farmaceuticas.

Country Status (15)

Country Link
EP (1) EP0898569A1 (es)
JP (1) JP2000508670A (es)
KR (1) KR20000005505A (es)
AR (1) AR006690A1 (es)
AU (1) AU2696797A (es)
BR (1) BR9708677A (es)
CA (1) CA2252385A1 (es)
CZ (1) CZ330598A3 (es)
DE (1) DE19615232A1 (es)
HU (1) HUP9901389A3 (es)
NO (1) NO984861D0 (es)
PL (1) PL329351A1 (es)
SK (1) SK141998A3 (es)
WO (1) WO1997040038A1 (es)
ZA (1) ZA973301B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19756036A1 (de) 1997-12-17 1999-06-24 Merck Patent Gmbh Amid- und Harnstoffderivate
CA2327513A1 (en) * 1998-04-08 1999-10-14 James Albert Nelson N-aryloxyethyl-indoly-alkylamines for the treatment of depression
US6150533A (en) * 1998-04-08 2000-11-21 American Home Products Corp. N-aryloxyethyl-indoly-alkylamines for the treatment of depression
AR015035A1 (es) * 1998-04-29 2001-04-11 American Home Prod Agentes serotonergicos, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamento
CN1312802A (zh) * 1998-06-15 2001-09-12 美国家用产品公司 作为5－羟色胺能药物的环烷基取代的芳基哌嗪、哌啶和四氢吡啶
US6376494B1 (en) 1998-06-15 2002-04-23 American Home Products Corporation Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
AU3123500A (en) * 1998-12-17 2000-07-03 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetrahydropyridine urea derivatives having 5ht1areceptor activity
CN1210261C (zh) * 1998-12-17 2005-07-13 惠氏公司 具有5ht1a受体活性的芳基哌啶和芳基－1,2,5,6－四氢吡啶酰胺衍生物
US6239126B1 (en) 1998-12-17 2001-05-29 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetra-hydropyridine urea derivatives
US6326381B1 (en) 1998-12-17 2001-12-04 American Home Products Corporation Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates
TR200101939T2 (tr) * 1999-01-28 2002-05-21 Bristol-Myers Squibb Company Antidepresan heterosiklik bileşikler
US20040096432A1 (en) * 2000-12-27 2004-05-20 Bernd Fleischmann System for the cell-specific and development-specific selection of differentiating embryonic stem cells, adult stem cells and embryonic germline cells
KR100459917B1 (ko) * 2001-12-14 2004-12-03 (주)바이오뉴트리젠 페놀릭산 유도체 및 이를 포함하는 혈중 지질 농도 관련질환의 예방 및 치료용 조성물
DE10337184A1 (de) * 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
UY36390A (es) * 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
EP3215141A4 (en) 2014-11-05 2018-06-06 Flexus Biosciences, Inc. Immunoregulatory agents
CN118647615A (zh) 2022-01-29 2024-09-13 苏文生命科学有限公司 用于治疗精神障碍的苯并异噻唑和苯并异噁唑化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3226392A (en) * 1960-03-07 1965-12-28 Sterling Drug Inc 1-[n-aryl-n-acylaminoalkyl]-4-aryl-1,2,3,6-tetrahydropyridines, the corresponding piperidines and their salts
US3647790A (en) * 1969-04-08 1972-03-07 American Home Prod Ouinoxalinyl-oxazolidines and -oxazines
US4782071A (en) * 1986-11-03 1988-11-01 Warner-Lambert Company Tetrasubstituted urea cholinergic agents
MX9201991A (es) * 1991-05-02 1992-11-01 Jonh Wyeth & Brother Limited Derivados de piperazina y procedimiento para su preparacion.
FR2706894A1 (en) * 1993-06-22 1994-12-30 Synthelabo N-Phenyl-N-(piperidinoalkyl)arylamide derivatives, their preparation and their application in therapeutics
GB9314758D0 (en) * 1993-07-16 1993-08-25 Wyeth John & Brother Ltd Heterocyclic derivatives
EP0661266A1 (en) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituted cyclic amine compounds as 5HT2 antagonists
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives

Also Published As

Publication number Publication date
CA2252385A1 (en) 1997-10-30
HUP9901389A2 (hu) 1999-08-30
ZA973301B (en) 1997-10-24
DE19615232A1 (de) 1997-10-23
BR9708677A (pt) 1999-08-03
JP2000508670A (ja) 2000-07-11
NO984861L (no) 1998-10-16
KR20000005505A (ko) 2000-01-25
AU2696797A (en) 1997-11-12
NO984861D0 (no) 1998-10-16
WO1997040038A1 (en) 1997-10-30
EP0898569A1 (en) 1999-03-03
HUP9901389A3 (en) 2000-09-28
PL329351A1 (en) 1999-03-29
SK141998A3 (en) 1999-03-12
CZ330598A3 (cs) 1999-01-13

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