AR002273A1 - Derivados de la 4-amino-benzoilguanidina, un procedimiento para prepararlos, el empleo de los mismos para preparar un medicamento, laspreparaciones farmaceuticas que las contienen y un procedimiento para preparar estas preparaciones farmaceuticas. - Google Patents

Derivados de la 4-amino-benzoilguanidina, un procedimiento para prepararlos, el empleo de los mismos para preparar un medicamento, laspreparaciones farmaceuticas que las contienen y un procedimiento para preparar estas preparaciones farmaceuticas.

Info

Publication number
AR002273A1
AR002273A1 ARP960101165A AR10116596A AR002273A1 AR 002273 A1 AR002273 A1 AR 002273A1 AR P960101165 A ARP960101165 A AR P960101165A AR 10116596 A AR10116596 A AR 10116596A AR 002273 A1 AR002273 A1 AR 002273A1
Authority
AR
Argentina
Prior art keywords
prepare
pharmaceutical preparations
procedure
atoms
amino
Prior art date
Application number
ARP960101165A
Other languages
English (en)
Inventor
Rolf Dr Gericke
Manfred Dr Baumgarth
Klaus-Otto Dr Minck
Norbert Dr Beier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR002273A1 publication Critical patent/AR002273A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

El invento se refiere a las 4-amino-benzoilguanidinas de fórmula (I) en la que R1 representa A, CF3, CH2F, CHF2 o C2F5; R2 y R3 representan,independientemente uno del otro, respectivamente H, A, cicloalquilo de 3 a 7 átomos de C, Ph o Het; R2 y R3 juntos también representan alquileno de 4 a 5átomos de C; Het representa un heterociclo de uno o dos núcleos, saturado, insaturado o aromático, con 1 a 4 átomos de N, O y/o S, unido a través de N oC, que puede estar no sustituido o sustituidouna, dos o tres veces con Hal, CF3, A, OH, OA, SH, SA, NH2, NHA, NA2, CN, NO2 y/o carbonilo-oxígeno, A esalquilo de 1 a 6 átomos de C; Hal es F, Cl, Br ó I y Ph representa fenilo no sustituido o sustituido una, dos o tres veces con A, OA, NH2,NHA, NA2, F, Cl,Br y/o CF3; y a sus sales aceptables desde el punto de vista fisiológico. También se refiere a un procedimiento para preparar dichos compuesto, apreparaciones farmacéuticas que los contienen y al empleo de los mismos para eltratamiento de las arritmias, de la angina de pecho, infartos y también parael tratamiento preventivo de estas enfermedades. Los nuevos compuestos del invento poseen propiedades antiarrítmicas y un efecto inhibidor del mecanismode intercambio deNa(+)/H(+) de las células.
ARP960101165A 1995-01-28 1996-01-26 Derivados de la 4-amino-benzoilguanidina, un procedimiento para prepararlos, el empleo de los mismos para preparar un medicamento, laspreparaciones farmaceuticas que las contienen y un procedimiento para preparar estas preparaciones farmaceuticas. AR002273A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19502644A DE19502644A1 (de) 1995-01-28 1995-01-28 4-Amino-benzoylguanidin-Derivate

Publications (1)

Publication Number Publication Date
AR002273A1 true AR002273A1 (es) 1998-03-11

Family

ID=7752517

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960101165A AR002273A1 (es) 1995-01-28 1996-01-26 Derivados de la 4-amino-benzoilguanidina, un procedimiento para prepararlos, el empleo de los mismos para preparar un medicamento, laspreparaciones farmaceuticas que las contienen y un procedimiento para preparar estas preparaciones farmaceuticas.

Country Status (28)

Country Link
US (1) US5739142A (es)
EP (1) EP0723963B1 (es)
JP (1) JP3770946B2 (es)
KR (1) KR100521853B1 (es)
CN (1) CN1057999C (es)
AR (1) AR002273A1 (es)
AT (1) ATE202093T1 (es)
AU (1) AU705632B2 (es)
BR (1) BR9600217A (es)
CA (1) CA2168192C (es)
CO (1) CO4700428A1 (es)
CZ (1) CZ289922B6 (es)
DE (2) DE19502644A1 (es)
DK (1) DK0723963T3 (es)
ES (1) ES2158153T3 (es)
FI (1) FI960376A (es)
GR (1) GR3036572T3 (es)
HU (1) HUP9600173A3 (es)
NO (1) NO305793B1 (es)
PL (1) PL182219B1 (es)
PT (1) PT723963E (es)
RU (1) RU2160728C2 (es)
SI (1) SI0723963T1 (es)
SK (1) SK281198B6 (es)
TR (1) TR199600064A2 (es)
TW (1) TW325463B (es)
UA (1) UA56983C2 (es)
ZA (1) ZA96629B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4328352A1 (de) * 1993-08-24 1995-03-02 Hoechst Ag Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19737463A1 (de) * 1997-08-28 1999-03-04 Hoechst Marion Roussel De Gmbh Verwendung von Inhibitoren des Natrium-Wasserstoff-Austauschers zur Herstellung eines Arzneimittels zur Behandlung von Erkrankungen, die durch Protozoen verursacht werden
CA2325471C (en) * 1998-03-23 2010-08-17 Aventis Pharmaceuticals Products Inc. Piperididinyl and n-amidinopiperidinyl derivatives
AU1553500A (en) * 1998-11-26 2000-06-13 Merck Patent Gmbh Use of benzoylguanidines for the treatment of non-insulin-dependent diabetes mellitus
DE19859727A1 (de) * 1998-12-23 2000-06-29 Aventis Pharma Gmbh Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung
DE10023405A1 (de) * 2000-05-12 2001-11-15 Merck Patent Gmbh Verfahren zur Herstellung von Sulfonyl-benzoylguanidinum-Salzen
SA04250283B1 (ar) * 2003-09-26 2008-05-26 سولفاي فارماسيتيكالز جي أم بي أتش مشتقات من amidomethy1-substituted1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid
DE102005030400A1 (de) * 2005-06-27 2006-12-28 Archimica Gmbh Verfahren zur Herstellung von Arylaminen, Arylethern und Arylthioethern

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
ES2097409T3 (es) * 1992-09-22 1997-04-01 Hoechst Ag Benzoilguanidinas, procedimiento para su preparacion, asi como su empleo como antiarritmicos.
DE4328869A1 (de) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
CO4700428A1 (es) 1998-12-29
PT723963E (pt) 2001-11-30
AU4211296A (en) 1996-08-08
HUP9600173A2 (en) 1997-01-28
CN1057999C (zh) 2000-11-01
CN1138575A (zh) 1996-12-25
PL312490A1 (en) 1996-08-05
FI960376A0 (fi) 1996-01-26
NO960353D0 (no) 1996-01-26
JPH08269001A (ja) 1996-10-15
HUP9600173A3 (en) 1998-07-28
EP0723963B1 (de) 2001-06-13
DK0723963T3 (da) 2001-09-24
PL182219B1 (pl) 2001-11-30
SK281198B6 (sk) 2001-01-18
UA56983C2 (uk) 2003-06-16
SK12296A3 (en) 1996-09-04
NO305793B1 (no) 1999-07-26
BR9600217A (pt) 1998-01-06
DE19502644A1 (de) 1996-08-01
CZ289922B6 (cs) 2002-04-17
TR199600064A2 (tr) 1996-08-21
EP0723963A1 (de) 1996-07-31
FI960376A (fi) 1996-07-29
RU2160728C2 (ru) 2000-12-20
DE59607054D1 (de) 2001-07-19
NO960353L (no) 1996-07-29
CA2168192C (en) 2008-07-29
CZ25296A3 (en) 1997-03-12
KR960029319A (ko) 1996-08-17
AU705632B2 (en) 1999-05-27
GR3036572T3 (en) 2001-12-31
ES2158153T3 (es) 2001-09-01
ZA96629B (en) 1996-10-24
US5739142A (en) 1998-04-14
ATE202093T1 (de) 2001-06-15
SI0723963T1 (en) 2002-08-31
TW325463B (en) 1998-01-21
CA2168192A1 (en) 1996-07-29
KR100521853B1 (ko) 2006-06-16
JP3770946B2 (ja) 2006-04-26

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