ATE307120T1 - Verfahren zur herstellung von 2-amino-4(4- fluorphenyl)-6-alkylpyrimidin-5-carbonsäureeste - Google Patents

Verfahren zur herstellung von 2-amino-4(4- fluorphenyl)-6-alkylpyrimidin-5-carbonsäureeste

Info

Publication number
ATE307120T1
ATE307120T1 AT00949231T AT00949231T ATE307120T1 AT E307120 T1 ATE307120 T1 AT E307120T1 AT 00949231 T AT00949231 T AT 00949231T AT 00949231 T AT00949231 T AT 00949231T AT E307120 T1 ATE307120 T1 AT E307120T1
Authority
AT
Austria
Prior art keywords
sup
amino
formula
alkylpyrimidine
fluorophenyl
Prior art date
Application number
AT00949231T
Other languages
English (en)
Inventor
Ulrich Veith
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Application granted granted Critical
Publication of ATE307120T1 publication Critical patent/ATE307120T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00949231T 1999-07-13 2000-06-30 Verfahren zur herstellung von 2-amino-4(4- fluorphenyl)-6-alkylpyrimidin-5-carbonsäureeste ATE307120T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP99113711 1999-07-13
EP99120417 1999-10-14
US18546500P 2000-02-28 2000-02-28
US18537100P 2000-02-28 2000-02-28
EP00106303 2000-03-23
PCT/EP2000/006099 WO2001004100A1 (en) 1999-07-13 2000-06-30 Process for preparing 2-amino-4-(4-fluorphenyl)-6-alkylpyrimidine-5-carboxylate

Publications (1)

Publication Number Publication Date
ATE307120T1 true ATE307120T1 (de) 2005-11-15

Family

ID=27513029

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00949231T ATE307120T1 (de) 1999-07-13 2000-06-30 Verfahren zur herstellung von 2-amino-4(4- fluorphenyl)-6-alkylpyrimidin-5-carbonsäureeste

Country Status (17)

Country Link
US (3) US6579984B1 (de)
EP (1) EP1194414B1 (de)
JP (1) JP4649813B2 (de)
KR (1) KR100649927B1 (de)
CN (1) CN1164577C (de)
AT (1) ATE307120T1 (de)
AU (1) AU6266600A (de)
CA (1) CA2378782C (de)
CZ (1) CZ304307B6 (de)
DE (1) DE60023296T2 (de)
ES (1) ES2251392T3 (de)
HK (1) HK1046682B (de)
HU (1) HU228303B1 (de)
NO (2) NO328103B1 (de)
PL (1) PL211797B1 (de)
SK (1) SK285993B6 (de)
WO (1) WO2001004100A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0003305D0 (en) * 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
EP1417180B1 (de) * 2001-07-13 2006-12-27 AstraZeneca UK Limited Herstellung von aminopyrimidinverbindungen
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
AU2003288443B2 (en) 2002-12-16 2007-10-25 Astrazeneka Uk Limited Process for the preparation of pyrimidine compounds
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
EP2423195A1 (de) 2010-07-26 2012-02-29 LEK Pharmaceuticals d.d. Verfahren zur Herstellung von wesentlichen Zwischenstufen zur Synthese von Rosuvastatin oder pharmazeutisch annehmbaren Salzen davon
US8609717B2 (en) 2010-08-18 2013-12-17 Samumed, Llc β- and γ-diketones and γ-hydroxyketones as WNT/β-catenin signaling pathway activators
ES2709824T3 (es) 2013-02-22 2019-04-17 Samumed Llc Gamma-dicetonas como activadores de la ruta de señalización Wnt/beta-catenina
CN103910644B (zh) * 2014-04-21 2015-06-24 广西师范大学 β-烯胺酮酯类化合物及其合成方法和应用
RU2727039C2 (ru) 2014-08-20 2020-07-17 СЭМЬЮМЕД, ЭлЭлСи Гамма-дикетоны для лечения и профилактики старения кожи и морщин
CN110483341A (zh) * 2019-07-23 2019-11-22 上海药明康德新药开发有限公司 一种1-氰基-n-甲基甲磺酰胺的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013706A (en) * 1973-11-14 1977-03-22 Sucreries Du Soissonnais Et Compagnie Sucriere Derivatives of substituted urea, acyl ureas, and sulphonyl ureas, and a process for producing the same
DE3717815A1 (de) 1987-05-27 1988-12-15 Bayer Ag Fungizide mittel auf basis von substituierten cyanamiden
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
JP3197971B2 (ja) * 1993-03-01 2001-08-13 塩野義製薬株式会社 ５−カルボアルコキシピリミジン誘導体の合成方法

Also Published As

Publication number Publication date
WO2001004100A1 (en) 2001-01-18
NO20020163L (no) 2002-01-11
CA2378782C (en) 2009-11-10
HUP0202006A2 (hu) 2002-12-28
NO328103B1 (no) 2009-12-07
US6984757B2 (en) 2006-01-10
JP2003504359A (ja) 2003-02-04
DE60023296T2 (de) 2006-07-20
KR100649927B1 (ko) 2006-11-27
NO334937B1 (no) 2014-07-21
AU6266600A (en) 2001-01-30
US6710178B2 (en) 2004-03-23
US20030199695A1 (en) 2003-10-23
DE60023296D1 (de) 2006-03-02
CZ200261A3 (cs) 2002-05-15
PL211797B1 (pl) 2012-06-29
HU228303B1 (hu) 2013-03-28
KR20020012007A (ko) 2002-02-09
EP1194414A1 (de) 2002-04-10
HK1046682A1 (en) 2003-01-24
SK285993B6 (sk) 2008-01-07
EP1194414B1 (de) 2005-10-19
CA2378782A1 (en) 2001-01-18
SK222002A3 (en) 2002-06-04
US6579984B1 (en) 2003-06-17
CN1370151A (zh) 2002-09-18
NO20020163D0 (no) 2002-01-11
NO20092393L (no) 2002-01-11
CN1164577C (zh) 2004-09-01
CZ304307B6 (cs) 2014-02-26
US20040181065A1 (en) 2004-09-16
HK1046682B (zh) 2005-04-08
JP4649813B2 (ja) 2011-03-16
PL353058A1 (en) 2003-10-06
HUP0202006A3 (en) 2003-02-28
ES2251392T3 (es) 2006-05-01

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