ATE231858T1 - Verfahren zur herstellung von 3-substituierten 4- phenyl-piperidin derivaten - Google Patents

Verfahren zur herstellung von 3-substituierten 4- phenyl-piperidin derivaten

Info

Publication number
ATE231858T1
ATE231858T1 AT00116505T AT00116505T ATE231858T1 AT E231858 T1 ATE231858 T1 AT E231858T1 AT 00116505 T AT00116505 T AT 00116505T AT 00116505 T AT00116505 T AT 00116505T AT E231858 T1 ATE231858 T1 AT E231858T1
Authority
AT
Austria
Prior art keywords
phenyl
substituted
producing
piperidine derivatives
derivatives
Prior art date
Application number
AT00116505T
Other languages
English (en)
Inventor
Ferra Lorenzo De
Pietro Massardo
Oreste Piccolo
Giorgio Cignarella
Original Assignee
Chemi Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemi Spa filed Critical Chemi Spa
Application granted granted Critical
Publication of ATE231858T1 publication Critical patent/ATE231858T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT00116505T 1999-08-02 2000-07-31 Verfahren zur herstellung von 3-substituierten 4- phenyl-piperidin derivaten ATE231858T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI001731A IT1313702B1 (it) 1999-08-02 1999-08-02 Processo per la preparazione di derivati 3-sostituiti di 4-fenil-piperidine.

Publications (1)

Publication Number Publication Date
ATE231858T1 true ATE231858T1 (de) 2003-02-15

Family

ID=11383481

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00116505T ATE231858T1 (de) 1999-08-02 2000-07-31 Verfahren zur herstellung von 3-substituierten 4- phenyl-piperidin derivaten

Country Status (8)

Country Link
US (1) US6444822B1 (de)
EP (1) EP1074550B1 (de)
JP (1) JP2001081089A (de)
AT (1) ATE231858T1 (de)
CA (1) CA2314750A1 (de)
DE (1) DE60001296T2 (de)
ES (1) ES2191587T3 (de)
IT (1) IT1313702B1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69739561D1 (de) 1996-06-13 2009-10-15 Sumitomo Chemical Co Piperidin Derivative als Zwischenprodukte zur Herstellung von Paroxetine und Verfahren zu ihrer Herstellung
GB9930577D0 (en) * 1999-12-23 2000-02-16 Smithkline Beecham Plc Novel process
HUP0401895A2 (hu) 2001-10-22 2004-12-28 Synthon B.V. Paroxetin N-formil származékai, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
CN102008978B (zh) * 2010-11-24 2012-10-03 郑州大学 手性催化剂及其制备方法和应用
WO2017037662A1 (en) * 2015-09-03 2017-03-09 Piramal Enterprises Limited An improved process for the preparation of paroxetine and its intermediate
WO2023102477A1 (en) * 2021-12-02 2023-06-08 The Johns Hopkins University Peripherally and luminally-restricted inhibitors of the serotonin transporter as treatments for disorders of gastrointestinal motility

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
EP0190496A3 (de) 1984-12-13 1987-05-27 Beecham Group Plc Piperidinderivate mit gastro-intestinaler Wirkung
DE3680184D1 (de) 1985-08-10 1991-08-14 Beecham Group Plc Verfahren zur herstellung von arylpiperidincarbinol.
DK716088D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Reduktion af piperidin-dion-derivater samt intermediat
DK715988D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Etherifikation og dealkylering af piperidin-derivater samt intermediater
US5258517A (en) * 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
JPH11505229A (ja) 1995-05-17 1999-05-18 ノボ ノルディスク アクティーゼルスカブ ４−アリール−ピペリジン誘導体を製造する方法
NZ315677A (en) * 1995-09-07 2000-02-28 F 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency
HU221921B1 (hu) * 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
AP9901698A0 (en) * 1997-05-29 1999-12-31 Smithkline Beecham Corp Novel process.

Also Published As

Publication number Publication date
DE60001296D1 (de) 2003-03-06
US6444822B1 (en) 2002-09-03
ITMI991731A1 (it) 2001-02-02
EP1074550A1 (de) 2001-02-07
JP2001081089A (ja) 2001-03-27
EP1074550B1 (de) 2003-01-29
DE60001296T2 (de) 2003-12-11
IT1313702B1 (it) 2002-09-09
ITMI991731A0 (it) 1999-08-02
CA2314750A1 (en) 2001-02-02
ES2191587T3 (es) 2003-09-16

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