ATE299147T1 - Verfahren zur herstellung von 3-amino-1,5- benzodiazepinderivaten - Google Patents
Verfahren zur herstellung von 3-amino-1,5- benzodiazepinderivatenInfo
- Publication number
- ATE299147T1 ATE299147T1 AT01929500T AT01929500T ATE299147T1 AT E299147 T1 ATE299147 T1 AT E299147T1 AT 01929500 T AT01929500 T AT 01929500T AT 01929500 T AT01929500 T AT 01929500T AT E299147 T1 ATE299147 T1 AT E299147T1
- Authority
- AT
- Austria
- Prior art keywords
- amino
- producing
- compound
- benzodiazepine derivatives
- acid addition
- Prior art date
Links
- CDGUEDBBMRZLEE-UHFFFAOYSA-N 1h-1,5-benzodiazepin-3-amine Chemical class N1=CC(N)=CNC2=CC=CC=C21 CDGUEDBBMRZLEE-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0008179.4A GB0008179D0 (en) | 2000-04-05 | 2000-04-05 | Chemical process |
| PCT/EP2001/003820 WO2001077143A2 (en) | 2000-04-05 | 2001-04-04 | Process for the preparation of 3-amino-1, 5-benzodiazepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE299147T1 true ATE299147T1 (de) | 2005-07-15 |
Family
ID=9889106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01929500T ATE299147T1 (de) | 2000-04-05 | 2001-04-04 | Verfahren zur herstellung von 3-amino-1,5- benzodiazepinderivaten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6673921B2 (de) |
| EP (1) | EP1268517B1 (de) |
| JP (1) | JP2003530404A (de) |
| AT (1) | ATE299147T1 (de) |
| AU (1) | AU2001256253A1 (de) |
| DE (1) | DE60111834T2 (de) |
| ES (1) | ES2241817T3 (de) |
| GB (1) | GB0008179D0 (de) |
| WO (1) | WO2001077143A2 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2254873B1 (de) | 2008-02-22 | 2014-06-04 | Otsuka Pharmaceutical Co., Ltd. | Benzodiazepinverbindung und pharmazeutische zusammensetzung |
| KR20120065360A (ko) | 2009-08-21 | 2012-06-20 | 오츠카 세이야쿠 가부시키가이샤 | 벤조［ｂ］［1,4］디아제핀-2,4-디온 화합물의 제조 방법 |
| TWI481601B (zh) | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2641280B1 (fr) * | 1988-12-29 | 1994-01-21 | Roussel Uclaf | Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments |
| GB9308421D0 (en) | 1993-04-23 | 1993-06-09 | Glaxo Spa | Chemical compounds |
| DE69430068T2 (de) | 1993-12-28 | 2002-08-14 | SHIONOGI & CO., LTD. | Benzodiazepinderivate |
| US5691331A (en) * | 1995-06-07 | 1997-11-25 | Merck & Co., Inc. | N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides |
-
2000
- 2000-04-05 GB GBGB0008179.4A patent/GB0008179D0/en not_active Ceased
-
2001
- 2001-04-04 JP JP2001575613A patent/JP2003530404A/ja not_active Ceased
- 2001-04-04 ES ES01929500T patent/ES2241817T3/es not_active Expired - Lifetime
- 2001-04-04 AU AU2001256253A patent/AU2001256253A1/en not_active Abandoned
- 2001-04-04 WO PCT/EP2001/003820 patent/WO2001077143A2/en not_active Ceased
- 2001-04-04 DE DE60111834T patent/DE60111834T2/de not_active Expired - Fee Related
- 2001-04-04 EP EP01929500A patent/EP1268517B1/de not_active Expired - Lifetime
- 2001-04-04 AT AT01929500T patent/ATE299147T1/de not_active IP Right Cessation
- 2001-04-04 US US10/240,905 patent/US6673921B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001077143A2 (en) | 2001-10-18 |
| JP2003530404A (ja) | 2003-10-14 |
| EP1268517A2 (de) | 2003-01-02 |
| DE60111834D1 (de) | 2005-08-11 |
| EP1268517B1 (de) | 2005-07-06 |
| AU2001256253A1 (en) | 2001-10-23 |
| ES2241817T3 (es) | 2005-11-01 |
| DE60111834T2 (de) | 2006-04-27 |
| WO2001077143A3 (en) | 2002-01-24 |
| GB0008179D0 (en) | 2000-05-24 |
| US20030158082A1 (en) | 2003-08-21 |
| US6673921B2 (en) | 2004-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |