DE60003807D1 - Enantiomere von mercaptolactonen und verfahren zu ihrer herstellung - Google Patents

Enantiomere von mercaptolactonen und verfahren zu ihrer herstellung

Info

Publication number
DE60003807D1
DE60003807D1 DE60003807T DE60003807T DE60003807D1 DE 60003807 D1 DE60003807 D1 DE 60003807D1 DE 60003807 T DE60003807 T DE 60003807T DE 60003807 T DE60003807 T DE 60003807T DE 60003807 D1 DE60003807 D1 DE 60003807D1
Authority
DE
Germany
Prior art keywords
enantiomers
mercaptolactones
production
processes
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60003807T
Other languages
English (en)
Other versions
DE60003807T2 (de
Inventor
Werner Andersen
Evan Boswell
Jude Sharp
Xiaoming Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DE60003807D1 publication Critical patent/DE60003807D1/de
Publication of DE60003807T2 publication Critical patent/DE60003807T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
DE60003807T 1999-04-23 2000-03-28 Enantiomere von mercaptolactonen und verfahren zu ihrer herstellung Expired - Fee Related DE60003807T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9909229.8A GB9909229D0 (en) 1999-04-23 1999-04-23 Enantiomers of mercapto lactones and processes for their synthesis
GB9909229 1999-04-23
PCT/EP2000/002705 WO2000064882A2 (en) 1999-04-23 2000-03-28 Enantiomers of mercapto lactones and processes for their synthesis

Publications (2)

Publication Number Publication Date
DE60003807D1 true DE60003807D1 (de) 2003-08-14
DE60003807T2 DE60003807T2 (de) 2004-05-27

Family

ID=10852031

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60003807T Expired - Fee Related DE60003807T2 (de) 1999-04-23 2000-03-28 Enantiomere von mercaptolactonen und verfahren zu ihrer herstellung

Country Status (8)

Country Link
EP (1) EP1173430B1 (de)
JP (1) JP2002543069A (de)
AT (1) ATE244706T1 (de)
AU (1) AU3814800A (de)
DE (1) DE60003807T2 (de)
ES (1) ES2202090T3 (de)
GB (1) GB9909229D0 (de)
WO (1) WO2000064882A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0312584A (pt) 2002-07-08 2005-04-12 Pliva Istrazivacki Inst D O O Novas substâncias anti-inflamatórias não-esteróides, compostos e métodos para o uso das mesmas
PL375162A1 (en) 2002-07-08 2005-11-28 Pliva-Istrazivacki Institut D.O.O. Novel compounds, compositions as carriers for steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
WO2004005310A2 (en) 2002-07-08 2004-01-15 Pliva-Istrazivacki Institut D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
JP5192730B2 (ja) * 2006-05-29 2013-05-08 昭和電工株式会社 メルカプト複素環化合物の製造方法
EP2024330B1 (de) 2006-05-29 2012-04-25 Showa Denko K.K. Verfahren zur herstellung einer heterocyclischen mercaptoverbindung
WO2010147947A2 (en) 2009-06-16 2010-12-23 Schering Corporation NOVEL [3,2-c] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS, COMPOSITIONS AND USES THEREOF
WO2024125639A1 (zh) * 2022-12-16 2024-06-20 津药生物科技（天津）有限公司 新型糖皮质激素、其制备方法及用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR199801247T2 (xx) * 1995-12-29 1998-11-23 Glaxo Group Limited 17.beta.-karboksi, karbotio t�revleri ve amid androstan t�revleri.

Also Published As

Publication number Publication date
JP2002543069A (ja) 2002-12-17
ATE244706T1 (de) 2003-07-15
EP1173430A1 (de) 2002-01-23
DE60003807T2 (de) 2004-05-27
WO2000064882A2 (en) 2000-11-02
WO2000064882A3 (en) 2001-02-22
AU3814800A (en) 2000-11-10
EP1173430B1 (de) 2003-07-09
GB9909229D0 (en) 1999-06-16
ES2202090T3 (es) 2004-04-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee