ATE218572T1 - Verfahren zur herstellung von cefdinir - Google Patents
Verfahren zur herstellung von cefdinirInfo
- Publication number
- ATE218572T1 ATE218572T1 AT96943357T AT96943357T ATE218572T1 AT E218572 T1 ATE218572 T1 AT E218572T1 AT 96943357 T AT96943357 T AT 96943357T AT 96943357 T AT96943357 T AT 96943357T AT E218572 T1 ATE218572 T1 AT E218572T1
- Authority
- AT
- Austria
- Prior art keywords
- cefdinir
- pct
- date
- sec
- formula
- Prior art date
Links
- 229960003719 cefdinir Drugs 0.000 title abstract 5
- RTXOFQZKPXMALH-GHXIOONMSA-N cefdinir Chemical compound S1C(N)=NC(C(=N\O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 RTXOFQZKPXMALH-GHXIOONMSA-N 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 3
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 1
- MHABMANUFPZXEB-UHFFFAOYSA-N O-demethyl-aloesaponarin I Natural products O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=C(O)C(C(O)=O)=C2C MHABMANUFPZXEB-UHFFFAOYSA-N 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019950058695A KR0174431B1 (ko) | 1995-12-27 | 1995-12-27 | 세프디니르의 제조방법 |
| KR1019950058694A KR0174432B1 (ko) | 1995-12-27 | 1995-12-27 | 신규한 결정성 세프디니르 중간체 및 그의 제조방법 |
| PCT/KR1996/000250 WO1997024358A1 (en) | 1995-12-27 | 1996-12-26 | Process for preparation of cefdinir |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE218572T1 true ATE218572T1 (de) | 2002-06-15 |
Family
ID=26631527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96943357T ATE218572T1 (de) | 1995-12-27 | 1996-12-26 | Verfahren zur herstellung von cefdinir |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6093814A (de) |
| EP (1) | EP0874853B1 (de) |
| JP (1) | JP3948628B2 (de) |
| AT (1) | ATE218572T1 (de) |
| DE (1) | DE69621649T2 (de) |
| DK (1) | DK0874853T3 (de) |
| ES (1) | ES2175167T3 (de) |
| PT (1) | PT874853E (de) |
| WO (1) | WO1997024358A1 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5883247A (en) * | 1996-06-10 | 1999-03-16 | Hoffmann-La Roche Inc. | Preparation of cephem and isooxacephem derivatives |
| AT405283B (de) | 1997-04-04 | 1999-06-25 | Biochemie Gmbh | Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung |
| US20080113025A1 (en) * | 1998-11-02 | 2008-05-15 | Elan Pharma International Limited | Compositions comprising nanoparticulate naproxen and controlled release hydrocodone |
| JP4544692B2 (ja) * | 2000-04-13 | 2010-09-15 | 大塚化学株式会社 | 3−ビニル−セフェム化合物の製造方法 |
| KR100451672B1 (ko) * | 2001-06-05 | 2004-10-08 | 한미약품 주식회사 | 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법 |
| ITMI20012364A1 (it) * | 2001-11-09 | 2003-05-09 | Antibioticos Spa | Processo di sintesi della cefixima via alchil-o arilsolfonati |
| CN1617875A (zh) * | 2001-12-13 | 2005-05-18 | 兰贝克赛实验室有限公司 | 结晶二水合头孢地尼钾 |
| BR0215709A (pt) * | 2002-04-26 | 2005-03-29 | Ranbaxy Lab Ltd | Processo para a preparação de cefdinir |
| ITMI20020913A0 (it) * | 2002-04-29 | 2002-04-29 | Acs Dobfar Spa | Nuova forma cristallina del cefdinir |
| EP1554289B1 (de) * | 2002-08-13 | 2011-03-09 | Sandoz Ag | Ein cefdinir-zwischenprodukt |
| ITMI20022076A1 (it) | 2002-10-01 | 2004-04-02 | Antibioticos Spa | Sali di intermedi del cefdinir. |
| EP1609793A4 (de) * | 2003-03-24 | 2008-06-25 | Sandoz Ag | Neuer kristall von 7-¬2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido-3-vinyl-3-cephem-4-carbonsäure(syn-isomer) und verfahren zu dessen herstellung |
| WO2004104010A1 (en) * | 2003-05-20 | 2004-12-02 | Ranbaxy Laboratories Limited | Crystalline form of cefdinir |
| US20050137182A1 (en) * | 2003-06-02 | 2005-06-23 | Ramesh Dandala | Novel crystalline form of cefdinir |
| US20040242556A1 (en) * | 2003-06-02 | 2004-12-02 | Ramesh Dandala | Novel crystalline form of cefdinir |
| US20050113355A1 (en) * | 2003-09-12 | 2005-05-26 | Duerst Richard W. | Cefdinir pyridine salt |
| US20050059819A1 (en) * | 2003-09-12 | 2005-03-17 | Duerst Richard W. | Cefdinir pyridine salt |
| US20050059818A1 (en) * | 2003-09-12 | 2005-03-17 | Duerst Richard W. | Polymorph of a pharmaceutical |
| US20060142563A1 (en) * | 2004-03-16 | 2006-06-29 | Devalina Law | Crystalline anhydrous cefdinir and crystalline cefdinir hydrates |
| US20060211676A1 (en) * | 2004-03-16 | 2006-09-21 | Devalina Law | Crystalline anhydrous cefdinir and crystalline cefdinir hydrates |
| US20060142261A1 (en) * | 2004-03-16 | 2006-06-29 | Devalina Law | Crystalline anhydrous cefdinir and crystalline cefdinir hydrates |
| US20050209211A1 (en) * | 2004-03-16 | 2005-09-22 | Devalina Law | Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir |
| US20060069079A1 (en) * | 2004-09-27 | 2006-03-30 | Sever Nancy E | Stable amorphous cefdinir |
| US20050245738A1 (en) * | 2004-05-03 | 2005-11-03 | Lupin Ltd | Stable bioavailable crystalline form or cefdinir and a process for the preparation thereof |
| WO2006010978A1 (en) * | 2004-06-30 | 2006-02-02 | Wockhardt Limited | Cefdinir polymorphic forms, and imidazole salt |
| WO2006018807A1 (en) * | 2004-08-16 | 2006-02-23 | Ranbaxy Laboratories Limited | Crystalline forms of cefdinir |
| MX2007006018A (es) | 2004-11-30 | 2007-06-07 | Astellas Pharma Inc | Suspension farmaceutica oral novedosa de cristal de cefdinir. |
| WO2007053723A2 (en) * | 2005-10-31 | 2007-05-10 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of cefdinir |
| US20070128268A1 (en) * | 2005-12-07 | 2007-06-07 | Herwig Jennewein | Pharmaceutical compositions comprising an antibiotic |
| US8466096B2 (en) * | 2007-04-26 | 2013-06-18 | Afton Chemical Corporation | 1,3,2-dioxaphosphorinane, 2-sulfide derivatives for use as anti-wear additives in lubricant compositions |
| ITMI20071628A1 (it) * | 2007-08-06 | 2007-11-05 | Acs Dobfar Spa | Sintesi di 3-alchenilcefalosporine e nuovi intermedi utili ad esse correlati |
| KR101058135B1 (ko) * | 2008-04-04 | 2011-08-24 | 대웅바이오 주식회사 | 세프디니르 합성에 유용한 중간체 및 이를 이용하여세프디니르를 제조하는 방법 |
| CN101481383B (zh) * | 2008-12-31 | 2012-01-11 | 杭州奥默医药技术有限公司 | 头孢地尼酸式复盐化合物及制备方法 |
| CN102020664B (zh) * | 2010-11-30 | 2012-12-12 | 浙江工业大学 | 一种头孢地尼的合成方法 |
| CN103319503A (zh) * | 2013-06-09 | 2013-09-25 | 四川方向药业有限责任公司 | 一种头孢地尼的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK162718C (da) * | 1982-09-30 | 1992-05-11 | Fujisawa Pharmaceutical Co | Analogifremgangsmaade til fremstilling af 7-substitueret-3-vinyl-3-cephemforbindelser |
| IL113744A (en) * | 1990-11-09 | 1998-06-15 | Eisai Co Ltd | 3-cephem derivatives and their preparation |
| TW212181B (de) * | 1992-02-14 | 1993-09-01 | Hoechst Ag | |
| EP0720611A1 (de) * | 1994-07-22 | 1996-07-10 | Antibioticos S.P.A. | Glutaryl-7-aca-derivate und verfahren zu ihrem erhalt |
-
1996
- 1996-12-26 DK DK96943357T patent/DK0874853T3/da active
- 1996-12-26 ES ES96943357T patent/ES2175167T3/es not_active Expired - Lifetime
- 1996-12-26 WO PCT/KR1996/000250 patent/WO1997024358A1/en not_active Ceased
- 1996-12-26 DE DE69621649T patent/DE69621649T2/de not_active Expired - Lifetime
- 1996-12-26 AT AT96943357T patent/ATE218572T1/de not_active IP Right Cessation
- 1996-12-26 EP EP96943357A patent/EP0874853B1/de not_active Expired - Lifetime
- 1996-12-26 JP JP52423097A patent/JP3948628B2/ja not_active Expired - Lifetime
- 1996-12-26 US US09/068,719 patent/US6093814A/en not_active Expired - Lifetime
- 1996-12-26 PT PT96943357T patent/PT874853E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69621649D1 (de) | 2002-07-11 |
| PT874853E (pt) | 2002-09-30 |
| DK0874853T3 (da) | 2002-09-23 |
| US6093814A (en) | 2000-07-25 |
| EP0874853B1 (de) | 2002-06-05 |
| DE69621649T2 (de) | 2002-09-19 |
| JP2000502700A (ja) | 2000-03-07 |
| ES2175167T3 (es) | 2002-11-16 |
| WO1997024358A1 (en) | 1997-07-10 |
| JP3948628B2 (ja) | 2007-07-25 |
| EP0874853A1 (de) | 1998-11-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |