BRPI0509095A - método para produzir um composto aminofenol - Google Patents

método para produzir um composto aminofenol

Info

Publication number
BRPI0509095A
BRPI0509095A BRPI0509095-4A BRPI0509095A BRPI0509095A BR PI0509095 A BRPI0509095 A BR PI0509095A BR PI0509095 A BRPI0509095 A BR PI0509095A BR PI0509095 A BRPI0509095 A BR PI0509095A
Authority
BR
Brazil
Prior art keywords
substituted
formula
group
unsubstituted
producing
Prior art date
Application number
BRPI0509095-4A
Other languages
English (en)
Inventor
Hiroshi Kiyokawa
Shinji Aki
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BRPI0509095A publication Critical patent/BRPI0509095A/pt
Publication of BRPI0509095B1 publication Critical patent/BRPI0509095B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/74—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C215/76—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

MéTODO PARA PRODUZIR UM COMPOSTO AMINOFENOL A presente invenção proporciona um método industrialmente vantajoso para produzir compostos aminofenol, representados pela fórmula (1), por um procedimento simples e fácil, com uma alta produção e uma elevada pureza. A presente invenção proporciona um método para produzir um composto aminofenol representado pela fórmula (1): (onde cada um de R¬ 1¬ e R¬ 2¬, que podem ser iguais ou diferentes, é um átomo de hidrogênio, um grupo alquil inferior substituído ou não substituído, ou similar; R¬ 1¬ e R¬ 2¬, tomados juntos com o átomo de nitrogênio adjacente, podem formar um heterociclo com 5 ou 6 membros, com ou sem outros átomos intervenientes; o heterociclo pode ser substituído com 1 a 3 substituintes selecionados do grupo que consiste de um grupo hidroxila, um grupo alquil inferior substituído ou não substituído, um grupo aril substituído ou não substituído, um grupo arilóxi, substituído ou não substituído, ou similares; e o grupo hidroxila na fórmula (1) é substituído na posição 2 ou 4 para o grupo amino no anel fenil), o qual compreende permitir a um composto ciclohexanodiona representado pela fórmula (2) reagir com um composto amina representado pela fórmula (3) (onde R¬ 1¬ e R¬ 2¬ são conforme acima definidos), em uma condição neutra ou básica.
BRPI0509095-4A 2004-03-25 2005-03-25 Método para produzir um composto aminofenol BRPI0509095B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004-089652 2004-03-25
JP2004089652 2004-03-25
PCT/JP2005/006408 WO2005092832A1 (en) 2004-03-25 2005-03-25 Method of producing aminophenol compounds

Publications (2)

Publication Number Publication Date
BRPI0509095A true BRPI0509095A (pt) 2007-08-28
BRPI0509095B1 BRPI0509095B1 (pt) 2014-09-16

Family

ID=34962553

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509095-4A BRPI0509095B1 (pt) 2004-03-25 2005-03-25 Método para produzir um composto aminofenol

Country Status (22)

Country Link
US (1) US7750156B2 (pt)
EP (1) EP1727782B1 (pt)
KR (1) KR100766763B1 (pt)
CN (1) CN100478325C (pt)
AR (1) AR048043A1 (pt)
AU (1) AU2005226409B2 (pt)
BR (1) BRPI0509095B1 (pt)
CA (1) CA2559488C (pt)
CY (1) CY1113246T1 (pt)
DK (1) DK1727782T3 (pt)
EG (1) EG25686A (pt)
ES (1) ES2390079T3 (pt)
HK (1) HK1097823A1 (pt)
MY (1) MY143665A (pt)
PL (1) PL1727782T3 (pt)
PT (1) PT1727782E (pt)
RU (1) RU2376280C2 (pt)
SI (1) SI1727782T1 (pt)
TW (1) TWI380975B (pt)
UA (1) UA87301C2 (pt)
WO (1) WO2005092832A1 (pt)
ZA (1) ZA200607640B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201233389A (en) * 2005-10-05 2012-08-16 Otsuka Pharma Co Ltd Antituberculous therapeutic drugs and kit containing the same
FR2926297B1 (fr) 2008-01-10 2013-03-08 Centre Nat Rech Scient Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage.
DE102008053240A1 (de) 2008-10-25 2010-04-29 Saltigo Gmbh Herstellung von (N-Heterozyklyl)-Arylethern
EP2505198A1 (en) 2011-04-01 2012-10-03 Société Splicos Compounds for use as therapeutic agents affecting p53 expression and/or activity
FR2995895B1 (fr) * 2012-09-25 2015-01-30 Fonds De Dev Des Filieres Des Oleagineux Et Proteagineux Fidop Procede de synthese d'un compose aromatique
KR102597449B1 (ko) 2015-03-27 2023-11-03 오츠카 세이야쿠 가부시키가이샤 1-(4-히드록시페닐)-4-(4-트리플루오로메톡시페녹시)피페리딘 또는 그 염의 제조방법
CN106699635B (zh) * 2015-11-12 2019-10-22 北京福元医药股份有限公司 一种制备Delamanid中间体的方法
CN106938974A (zh) * 2017-03-24 2017-07-11 连云港恒贸化工有限公司 一种一锅法生产间二乙氨基苯酚的方法
CN110041334B (zh) * 2018-01-15 2020-10-20 江苏恒瑞医药股份有限公司 一种氨基苯酚类化合物的制备方法
CN109705022A (zh) * 2018-12-28 2019-05-03 上海彩迩文生化科技有限公司 一种芳香胺中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2402695C3 (de) * 1974-01-21 1980-05-29 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von 3-Aminophenolen
JPS6229557A (ja) 1985-07-29 1987-02-07 Otsuka Pharmaceut Factory Inc ジ低級アルキルフエノ−ル誘導体
US5202488A (en) * 1991-04-15 1993-04-13 E. I. Du Pont De Nemours And Company Method for the manufacture of 3-aminophenol
US7157458B2 (en) 2001-04-17 2007-01-02 Cryolife, Inc. Bifunctional energy-reversible acyl-compositions

Also Published As

Publication number Publication date
UA87301C2 (ru) 2009-07-10
ES2390079T3 (es) 2012-11-06
DK1727782T3 (da) 2012-10-08
TW200531958A (en) 2005-10-01
EP1727782B1 (en) 2012-08-22
BRPI0509095B1 (pt) 2014-09-16
KR20060123650A (ko) 2006-12-01
SI1727782T1 (sl) 2012-12-31
CN100478325C (zh) 2009-04-15
RU2376280C2 (ru) 2009-12-20
AR048043A1 (es) 2006-03-22
ZA200607640B (en) 2008-05-28
CY1113246T1 (el) 2016-04-13
US7750156B2 (en) 2010-07-06
CA2559488A1 (en) 2005-10-06
WO2005092832A1 (en) 2005-10-06
AU2005226409A1 (en) 2005-10-06
CN1938261A (zh) 2007-03-28
US20070219374A1 (en) 2007-09-20
TWI380975B (zh) 2013-01-01
MY143665A (en) 2011-06-30
CA2559488C (en) 2012-06-12
KR100766763B1 (ko) 2007-10-17
PT1727782E (pt) 2012-08-30
HK1097823A1 (en) 2007-07-06
PL1727782T3 (pl) 2013-01-31
EP1727782A1 (en) 2006-12-06
RU2006137563A (ru) 2008-04-27
EG25686A (en) 2012-05-17
AU2005226409B2 (en) 2008-04-17

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Legal Events

Date Code Title Description
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/03/2005, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)