MXPA05002985A - Nuevos compuestos de 4-oxo-4,6,7,8-tetrahidro-pirrolo[1,2-a]pirazin-6-carboxamida, un proceso para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos compuestos de 4-oxo-4,6,7,8-tetrahidro-pirrolo[1,2-a]pirazin-6-carboxamida, un proceso para su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
MXPA05002985A
MXPA05002985A MXPA05002985A MXPA05002985A MXPA05002985A MX PA05002985 A MXPA05002985 A MX PA05002985A MX PA05002985 A MXPA05002985 A MX PA05002985A MX PA05002985 A MXPA05002985 A MX PA05002985A MX PA05002985 A MXPA05002985 A MX PA05002985A
Authority
MX
Mexico
Prior art keywords
branched
linear
represent
tetrahydropyrrolo
carboxamides
Prior art date
Application number
MXPA05002985A
Other languages
English (en)
Inventor
Parmentier Jean-Gilles
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of MXPA05002985A publication Critical patent/MXPA05002985A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
    • A47J27/00—Cooking-vessels
    • A47J27/14—Cooking-vessels for use in hotels, restaurants, or canteens
    • A47J27/16—Cooking-vessels for use in hotels, restaurants, or canteens heated by steam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
    • A47J27/00—Cooking-vessels
    • A47J27/12—Multiple-unit cooking vessels
    • A47J27/13—Tier cooking-vessels
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
    • A47J36/00—Parts, details or accessories of cooking-vessels
    • A47J36/24—Warming devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invencion describe un compuesto de formula (I): (ver formula) en donde: (ver formula) representa un grupo 1-oxidopiridilo substituido por lo restante de la molecula en cualquiera de las posiciones 2, 3 y 4, * m y n, los cuales pueden ser identicos o diferentes, representan cada uno un entero desde 1 a 3, * R1 representa un atomo de hidrogeno o un grupo alquilo, * R2 y R3, los cuales pueden ser identicos o diferentes, representan cada uno un atomo o grupo seleccionado de los atomos hidrogeno y halogeno y los grupos alquilo, hidroxi, aciloxi y alcoxi, o juntos forman, con el atomo de carbono que los lleva, un cicloalcano que tiene de 3 a 6 atomos de carbono, * R4 y R5 representan cada uno un atomo de hidrogeno, o estan adyacentes y juntos forman, con el atomo de carbono que los lleva, un anillo de benzo, * Ar representa un grupo arilo o heteroarilo. Medicamentos.
MXPA05002985A 2004-03-19 2005-03-17 Nuevos compuestos de 4-oxo-4,6,7,8-tetrahidro-pirrolo[1,2-a]pirazin-6-carboxamida, un proceso para su preparacion y composiciones farmaceuticas que los contienen. MXPA05002985A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0402841A FR2867780B1 (fr) 2004-03-19 2004-03-19 Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
MXPA05002985A true MXPA05002985A (es) 2005-10-06

Family

ID=34896643

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05002985A MXPA05002985A (es) 2004-03-19 2005-03-17 Nuevos compuestos de 4-oxo-4,6,7,8-tetrahidro-pirrolo[1,2-a]pirazin-6-carboxamida, un proceso para su preparacion y composiciones farmaceuticas que los contienen.

Country Status (31)

Country Link
US (2) US7498330B2 (es)
EP (1) EP1593682B1 (es)
JP (1) JP2005272467A (es)
KR (1) KR100741236B1 (es)
CN (1) CN1297558C (es)
AR (1) AR048277A1 (es)
AT (1) ATE377601T1 (es)
AU (1) AU2005201198B8 (es)
BR (1) BRPI0500889A (es)
CA (1) CA2500575C (es)
CY (1) CY1107157T1 (es)
DE (1) DE602005003161T2 (es)
DK (1) DK1593682T3 (es)
EA (1) EA008688B1 (es)
ES (1) ES2296104T3 (es)
FR (1) FR2867780B1 (es)
GE (1) GEP20074035B (es)
HK (1) HK1079775A1 (es)
HR (1) HRP20070518T5 (es)
MA (1) MA27547A1 (es)
MX (1) MXPA05002985A (es)
MY (1) MY136910A (es)
NO (1) NO20051367L (es)
NZ (1) NZ538935A (es)
PL (1) PL1593682T3 (es)
PT (1) PT1593682E (es)
RS (1) RS50547B (es)
SG (1) SG115741A1 (es)
SI (1) SI1593682T1 (es)
UA (1) UA83638C2 (es)
ZA (1) ZA200502316B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2867780B1 (fr) * 2004-03-19 2006-05-19 Servier Lab Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN101092372B (zh) * 2006-06-20 2011-09-21 上海药明康德新药开发有限公司 光学活性α-氨基庚二酸酯或单酯的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2701951B1 (fr) * 1993-02-24 1995-06-09 Adir Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US6156540A (en) * 1993-12-22 2000-12-05 Human Genome Sciences, Inc. Thrombin inhibitor
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
AU720616B2 (en) * 1996-02-22 2000-06-08 Merck & Co., Inc. Pyridinone thrombin inhibitors
UA58636C2 (uk) * 1999-06-04 2003-08-15 Мерк Енд Ко., Інк. Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням
FR2795072B1 (fr) * 1999-06-15 2001-07-27 Adir Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2818277B1 (fr) * 2000-12-14 2003-01-24 Servier Lab Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2867780B1 (fr) * 2004-03-19 2006-05-19 Servier Lab Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
ZA200502316B (en) 2005-10-03
NO20051367L (no) 2005-09-20
HRP20070518T8 (en) 2008-10-31
CN1680377A (zh) 2005-10-12
HRP20070518T3 (en) 2007-12-31
AU2005201198B2 (en) 2010-11-11
EP1593682B1 (fr) 2007-11-07
GEP20074035B (en) 2007-02-12
EP1593682A2 (fr) 2005-11-09
SG115741A1 (en) 2005-10-28
HK1079775A1 (en) 2006-04-13
ATE377601T1 (de) 2007-11-15
MA27547A1 (fr) 2005-10-03
KR100741236B1 (ko) 2007-07-19
FR2867780A1 (fr) 2005-09-23
CY1107157T1 (el) 2012-10-24
CN1297558C (zh) 2007-01-31
DE602005003161D1 (de) 2007-12-20
CA2500575A1 (fr) 2005-09-19
KR20060044455A (ko) 2006-05-16
JP2005272467A (ja) 2005-10-06
NO20051367D0 (no) 2005-03-16
MY136910A (en) 2008-11-28
US20090131668A1 (en) 2009-05-21
FR2867780B1 (fr) 2006-05-19
DE602005003161T2 (de) 2008-09-18
BRPI0500889A (pt) 2005-11-01
AU2005201198B8 (en) 2011-03-10
HRP20070518T5 (en) 2008-10-31
PL1593682T3 (pl) 2008-03-31
PT1593682E (pt) 2007-12-06
EP1593682A3 (fr) 2006-01-18
ES2296104T3 (es) 2008-04-16
SI1593682T1 (sl) 2008-02-29
NZ538935A (en) 2005-09-30
AU2005201198A1 (en) 2005-10-06
US20050209234A1 (en) 2005-09-22
DK1593682T3 (da) 2008-03-03
EA200500379A1 (ru) 2005-10-27
US7498330B2 (en) 2009-03-03
RS50547B (sr) 2010-05-07
AR048277A1 (es) 2006-04-12
EA008688B1 (ru) 2007-06-29
CA2500575C (fr) 2010-06-22
UA83638C2 (ru) 2008-08-11

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