NO20051367L - Nye 4-okso-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazin-6-karboksamid-forbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem - Google Patents

Nye 4-okso-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazin-6-karboksamid-forbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem

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Publication number
NO20051367L
NO20051367L NO20051367A NO20051367A NO20051367L NO 20051367 L NO20051367 L NO 20051367L NO 20051367 A NO20051367 A NO 20051367A NO 20051367 A NO20051367 A NO 20051367A NO 20051367 L NO20051367 L NO 20051367L
Authority
NO
Norway
Prior art keywords
pyrrolo
pyrazine
tetrahydro
oxo
processes
Prior art date
Application number
NO20051367A
Other languages
English (en)
Other versions
NO20051367D0 (no
Inventor
Guillaume De Nanteuil
Tony Verbeuren
Marie-Odile Vallez
Alain Rupin
Alain Benoist
Jean-Gilles Parmentier
Philippe Gloanec
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of NO20051367D0 publication Critical patent/NO20051367D0/no
Publication of NO20051367L publication Critical patent/NO20051367L/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47JKITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
    • A47J27/00Cooking-vessels
    • A47J27/14Cooking-vessels for use in hotels, restaurants, or canteens
    • A47J27/16Cooking-vessels for use in hotels, restaurants, or canteens heated by steam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • AHUMAN NECESSITIES
    • A47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47JKITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
    • A47J27/00Cooking-vessels
    • A47J27/12Multiple-unit cooking vessels
    • A47J27/13Tier cooking-vessels
    • AHUMAN NECESSITIES
    • A47FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47JKITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
    • A47J36/00Parts, details or accessories of cooking-vessels
    • A47J36/24Warming devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Forbindelse med formel (I): (I) NH-(CH,)7At hvori: * I representerer en 1-oksidopyridylgruppe substituert o til resten av molekylet i enhver av stillingene 2, 3 og 4, * m og n, som kan være identiske eller forskjellige, representerer hver et heltall fra 1 til 3, * Ri representerer et hydrogenatom eller en alkylgruppe, * R2 og R3, som kan være identiske eller forskjellige, representerer hver et atom eller gruppe valgt fra ato- mene hydrogen og halogen og gruppene alkyl, hydroksy, acyloksy og alkoksy, eller danner, sammen med karbonato- met som bærer dem, et cykloalkan som har fra 3 til 6 karbonatomer, * R4 og R5 representerer hver et hydrogenatom, eller er nærliggende og danner, sammen med karbonatomene som bærer dem, en benzoring, * Ar representerer en aryl- eller heteroarylgruppe. Medikamenter.
NO20051367A 2004-03-19 2005-03-16 Nye 4-okso-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazin-6-karboksamid-forbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem NO20051367L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0402841A FR2867780B1 (fr) 2004-03-19 2004-03-19 Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
NO20051367D0 NO20051367D0 (no) 2005-03-16
NO20051367L true NO20051367L (no) 2005-09-20

Family

ID=34896643

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051367A NO20051367L (no) 2004-03-19 2005-03-16 Nye 4-okso-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazin-6-karboksamid-forbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem

Country Status (31)

Country Link
US (2) US7498330B2 (no)
EP (1) EP1593682B1 (no)
JP (1) JP2005272467A (no)
KR (1) KR100741236B1 (no)
CN (1) CN1297558C (no)
AR (1) AR048277A1 (no)
AT (1) ATE377601T1 (no)
AU (1) AU2005201198B8 (no)
BR (1) BRPI0500889A (no)
CA (1) CA2500575C (no)
CY (1) CY1107157T1 (no)
DE (1) DE602005003161T2 (no)
DK (1) DK1593682T3 (no)
EA (1) EA008688B1 (no)
ES (1) ES2296104T3 (no)
FR (1) FR2867780B1 (no)
GE (1) GEP20074035B (no)
HK (1) HK1079775A1 (no)
HR (1) HRP20070518T8 (no)
MA (1) MA27547A1 (no)
MX (1) MXPA05002985A (no)
MY (1) MY136910A (no)
NO (1) NO20051367L (no)
NZ (1) NZ538935A (no)
PL (1) PL1593682T3 (no)
PT (1) PT1593682E (no)
RS (1) RS50547B (no)
SG (1) SG115741A1 (no)
SI (1) SI1593682T1 (no)
UA (1) UA83638C2 (no)
ZA (1) ZA200502316B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2867780B1 (fr) * 2004-03-19 2006-05-19 Servier Lab Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN101092372B (zh) * 2006-06-20 2011-09-21 上海药明康德新药开发有限公司 光学活性α-氨基庚二酸酯或单酯的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2701951B1 (fr) * 1993-02-24 1995-06-09 Adir Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US6156540A (en) * 1993-12-22 2000-12-05 Human Genome Sciences, Inc. Thrombin inhibitor
IL112795A (en) * 1994-03-04 2001-01-28 Astrazeneca Ab Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them
CA2245811A1 (en) * 1996-02-22 1997-08-28 Merck & Co., Inc. Pyridinone thrombin inhibitors
UA58636C2 (uk) * 1999-06-04 2003-08-15 Мерк Енд Ко., Інк. Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням
FR2795072B1 (fr) * 1999-06-15 2001-07-27 Adir Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2818277B1 (fr) * 2000-12-14 2003-01-24 Servier Lab Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2867780B1 (fr) * 2004-03-19 2006-05-19 Servier Lab Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
DE602005003161D1 (de) 2007-12-20
AR048277A1 (es) 2006-04-12
AU2005201198B2 (en) 2010-11-11
SI1593682T1 (sl) 2008-02-29
HRP20070518T5 (en) 2008-10-31
BRPI0500889A (pt) 2005-11-01
UA83638C2 (ru) 2008-08-11
GEP20074035B (en) 2007-02-12
MXPA05002985A (es) 2005-10-06
ES2296104T3 (es) 2008-04-16
EP1593682B1 (fr) 2007-11-07
EP1593682A2 (fr) 2005-11-09
AU2005201198A1 (en) 2005-10-06
US20090131668A1 (en) 2009-05-21
CN1680377A (zh) 2005-10-12
US7498330B2 (en) 2009-03-03
SG115741A1 (en) 2005-10-28
KR20060044455A (ko) 2006-05-16
CA2500575A1 (fr) 2005-09-19
CY1107157T1 (el) 2012-10-24
EP1593682A3 (fr) 2006-01-18
PL1593682T3 (pl) 2008-03-31
CA2500575C (fr) 2010-06-22
RS50547B (sr) 2010-05-07
KR100741236B1 (ko) 2007-07-19
ATE377601T1 (de) 2007-11-15
CN1297558C (zh) 2007-01-31
EA200500379A1 (ru) 2005-10-27
AU2005201198B8 (en) 2011-03-10
FR2867780B1 (fr) 2006-05-19
PT1593682E (pt) 2007-12-06
ZA200502316B (en) 2005-10-03
JP2005272467A (ja) 2005-10-06
FR2867780A1 (fr) 2005-09-23
EA008688B1 (ru) 2007-06-29
DK1593682T3 (da) 2008-03-03
NO20051367D0 (no) 2005-03-16
HRP20070518T3 (en) 2007-12-31
NZ538935A (en) 2005-09-30
MY136910A (en) 2008-11-28
MA27547A1 (fr) 2005-10-03
HK1079775A1 (en) 2006-04-13
DE602005003161T2 (de) 2008-09-18
US20050209234A1 (en) 2005-09-22
HRP20070518T8 (en) 2008-10-31

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