DE602005003161D1 - 4-Oxo-4,6,7,8-tetrahydropyrroloi1,2-a pyrazin-6-carboxamid-Derivate, Vefahren zu deren Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen - Google Patents

4-Oxo-4,6,7,8-tetrahydropyrroloi1,2-a pyrazin-6-carboxamid-Derivate, Vefahren zu deren Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen

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Publication number
DE602005003161D1
DE602005003161D1 DE602005003161T DE602005003161T DE602005003161D1 DE 602005003161 D1 DE602005003161 D1 DE 602005003161D1 DE 602005003161 T DE602005003161 T DE 602005003161T DE 602005003161 T DE602005003161 T DE 602005003161T DE 602005003161 D1 DE602005003161 D1 DE 602005003161D1
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DE
Germany
Prior art keywords
pyrazine
oxo
processes
preparation
pharmaceutical compositions
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DE602005003161T
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English (en)
Other versions
DE602005003161T2 (de
Inventor
Nanteuil Guillaume De
Philippe Gloanec
Jean-Gilles Parmentier
Alain Benoist
Alain Rupin
Marie-Odile Vallez
Tony Verbeuren
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Laboratoires Servier SAS
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Laboratoires Servier SAS
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Publication of DE602005003161D1 publication Critical patent/DE602005003161D1/de
Application granted granted Critical
Publication of DE602005003161T2 publication Critical patent/DE602005003161T2/de
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
    • A47J27/00—Cooking-vessels
    • A47J27/14—Cooking-vessels for use in hotels, restaurants, or canteens
    • A47J27/16—Cooking-vessels for use in hotels, restaurants, or canteens heated by steam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
    • A47J27/00—Cooking-vessels
    • A47J27/12—Multiple-unit cooking vessels
    • A47J27/13—Tier cooking-vessels
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
    • A47J36/00—Parts, details or accessories of cooking-vessels
    • A47J36/24—Warming devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602005003161T 2004-03-19 2005-03-18 4-Oxo-4,6,7,8-tetrahydropyrrolo(1,2-a)pyrazin-6-carboxamid-Derivate, Vefahren zu deren Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen Active DE602005003161T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0402841 2004-03-19
FR0402841A FR2867780B1 (fr) 2004-03-19 2004-03-19 Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
DE602005003161D1 true DE602005003161D1 (de) 2007-12-20
DE602005003161T2 DE602005003161T2 (de) 2008-09-18

Family

ID=34896643

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005003161T Active DE602005003161T2 (de) 2004-03-19 2005-03-18 4-Oxo-4,6,7,8-tetrahydropyrrolo(1,2-a)pyrazin-6-carboxamid-Derivate, Vefahren zu deren Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen

Country Status (31)

Country Link
US (2) US7498330B2 (de)
EP (1) EP1593682B1 (de)
JP (1) JP2005272467A (de)
KR (1) KR100741236B1 (de)
CN (1) CN1297558C (de)
AR (1) AR048277A1 (de)
AT (1) ATE377601T1 (de)
AU (1) AU2005201198B8 (de)
BR (1) BRPI0500889A (de)
CA (1) CA2500575C (de)
CY (1) CY1107157T1 (de)
DE (1) DE602005003161T2 (de)
DK (1) DK1593682T3 (de)
EA (1) EA008688B1 (de)
ES (1) ES2296104T3 (de)
FR (1) FR2867780B1 (de)
GE (1) GEP20074035B (de)
HK (1) HK1079775A1 (de)
HR (1) HRP20070518T8 (de)
MA (1) MA27547A1 (de)
MX (1) MXPA05002985A (de)
MY (1) MY136910A (de)
NO (1) NO20051367L (de)
NZ (1) NZ538935A (de)
PL (1) PL1593682T3 (de)
PT (1) PT1593682E (de)
RS (1) RS50547B (de)
SG (1) SG115741A1 (de)
SI (1) SI1593682T1 (de)
UA (1) UA83638C2 (de)
ZA (1) ZA200502316B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2867780B1 (fr) * 2004-03-19 2006-05-19 Servier Lab Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN101092372B (zh) * 2006-06-20 2011-09-21 上海药明康德新药开发有限公司 光学活性α-氨基庚二酸酯或单酯的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2701951B1 (fr) * 1993-02-24 1995-06-09 Adir Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US6156540A (en) * 1993-12-22 2000-12-05 Human Genome Sciences, Inc. Thrombin inhibitor
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
EP0923372A4 (de) * 1996-02-22 2001-09-05 Merck & Co Inc Inhibitoren von pyridinone thrombin
UA58636C2 (uk) * 1999-06-04 2003-08-15 Мерк Енд Ко., Інк. Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням
FR2795072B1 (fr) * 1999-06-15 2001-07-27 Adir Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2818277B1 (fr) * 2000-12-14 2003-01-24 Servier Lab Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2867780B1 (fr) * 2004-03-19 2006-05-19 Servier Lab Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
CN1297558C (zh) 2007-01-31
JP2005272467A (ja) 2005-10-06
MY136910A (en) 2008-11-28
PL1593682T3 (pl) 2008-03-31
KR20060044455A (ko) 2006-05-16
CA2500575C (fr) 2010-06-22
BRPI0500889A (pt) 2005-11-01
DK1593682T3 (da) 2008-03-03
ES2296104T3 (es) 2008-04-16
US20050209234A1 (en) 2005-09-22
AU2005201198A1 (en) 2005-10-06
NO20051367D0 (no) 2005-03-16
FR2867780A1 (fr) 2005-09-23
HRP20070518T5 (en) 2008-10-31
AR048277A1 (es) 2006-04-12
US20090131668A1 (en) 2009-05-21
RS50547B (sr) 2010-05-07
NO20051367L (no) 2005-09-20
GEP20074035B (en) 2007-02-12
UA83638C2 (ru) 2008-08-11
EA008688B1 (ru) 2007-06-29
ATE377601T1 (de) 2007-11-15
DE602005003161T2 (de) 2008-09-18
AU2005201198B2 (en) 2010-11-11
HK1079775A1 (en) 2006-04-13
NZ538935A (en) 2005-09-30
EA200500379A1 (ru) 2005-10-27
CN1680377A (zh) 2005-10-12
MXPA05002985A (es) 2005-10-06
MA27547A1 (fr) 2005-10-03
SG115741A1 (en) 2005-10-28
SI1593682T1 (sl) 2008-02-29
AU2005201198B8 (en) 2011-03-10
FR2867780B1 (fr) 2006-05-19
PT1593682E (pt) 2007-12-06
EP1593682A2 (de) 2005-11-09
HRP20070518T8 (en) 2008-10-31
EP1593682B1 (de) 2007-11-07
ZA200502316B (en) 2005-10-03
CA2500575A1 (fr) 2005-09-19
CY1107157T1 (el) 2012-10-24
KR100741236B1 (ko) 2007-07-19
US7498330B2 (en) 2009-03-03
EP1593682A3 (de) 2006-01-18
HRP20070518T3 (en) 2007-12-31

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