BRPI0417046A - métodos para o preparo de aminas estereoisomericamente enriquecidas - Google Patents
métodos para o preparo de aminas estereoisomericamente enriquecidasInfo
- Publication number
- BRPI0417046A BRPI0417046A BRPI0417046-6A BRPI0417046A BRPI0417046A BR PI0417046 A BRPI0417046 A BR PI0417046A BR PI0417046 A BRPI0417046 A BR PI0417046A BR PI0417046 A BRPI0417046 A BR PI0417046A
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- aryl
- stereoisomerically enriched
- preparing
- alkenyl
- Prior art date
Links
- 150000001412 amines Chemical class 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 239000011942 biocatalyst Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/08—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/24—Proline; Hydroxyproline; Histidine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
"MéTODOS PARA O PREPARO DE AMINAS ESTéREO-ISOMERICAMENTE ENRIQUECIDAS". A presente invenção relaciona-se a métodos de preparo de um composto estereoisomericamente enriquecido de fórmula (I) , onde R¬ 6¬ é hidrogênio, compreendendo tratar um composto de fórmula (I) , onde R¬ 6¬ é escolhido a partir de alquila C~ 1~-C~ 10~/ alquenila C~ 2~-C~ 10~, alquenila C~ 2-C~ 10, - (CR¬ 7¬ R¬ 8¬)~ t~ (arila C~ 6~-C~ 14~), e(CR¬ 7¬R¬ 8¬)~ t~ (arila C~ 6~-C~14~), e -(CR¬ 7¬R¬ 8¬)~ t~ (heterocíclico de 4-10 membros), onde os referidos arila C~ 6~-C~ 14~ e heterocíclico de 4-10 membros são opcionalmente substituídos com pelo menos um substituinte escolhido entre halo, alquila C~ 1~-C~ 10~, -OR¬ 7¬, e -N(R¬ 7¬R¬ 8¬), com um biocatalisador em uma solução aquosa, um solvente orgânico, ou uma mistura de solventes orgãnicos e aquosos onde pelo menos um estereoisómero é seletivamente hidrolisado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52714303P | 2003-12-04 | 2003-12-04 | |
PCT/IB2004/003812 WO2005054186A2 (en) | 2003-12-04 | 2004-11-22 | Methods for the preparation of stereoisomerically enriched amines |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0417046A true BRPI0417046A (pt) | 2007-02-06 |
Family
ID=34652482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0417046-6A BRPI0417046A (pt) | 2003-12-04 | 2004-11-22 | métodos para o preparo de aminas estereoisomericamente enriquecidas |
Country Status (14)
Country | Link |
---|---|
US (1) | US20050192441A1 (pt) |
EP (1) | EP1737818A2 (pt) |
JP (1) | JP2007521801A (pt) |
KR (1) | KR20060100457A (pt) |
CN (1) | CN101068780A (pt) |
AU (1) | AU2004295187A1 (pt) |
BR (1) | BRPI0417046A (pt) |
CA (1) | CA2549289A1 (pt) |
CO (1) | CO5700727A2 (pt) |
IL (1) | IL175737A0 (pt) |
NO (1) | NO20062944L (pt) |
RU (1) | RU2006119470A (pt) |
WO (1) | WO2005054186A2 (pt) |
ZA (1) | ZA200604545B (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5119923B2 (ja) * | 2005-09-02 | 2013-01-16 | 宇部興産株式会社 | 光学活性(S又はR)−α−ヒドロキシ酸及び光学活性(R又はS)−α−ヒドロキシ酸エステルの製造方法 |
CN101284797B (zh) * | 2008-06-11 | 2010-08-11 | 常州恩滋生物科技有限公司 | N-保护的烯丙基甘氨酸酯的拆分方法 |
JP2012512415A (ja) * | 2008-12-17 | 2012-05-31 | ザ ルブリゾル コーポレイション | 機能性流体用光学活性マーカー |
CN103797124B (zh) * | 2011-07-20 | 2018-05-22 | 赢创德固赛有限公司 | 伯醇的氧化和胺化 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5644028A (en) * | 1992-05-13 | 1997-07-01 | Japan Energy Corporation | Process for producing peptide derivatives and salts therefor |
CA2179935C (en) * | 1995-06-30 | 2010-09-07 | Ryohei Kato | Novel dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof |
US6222043B1 (en) * | 1995-06-30 | 2001-04-24 | Japan Energy Corporation | Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof |
CN1213400A (zh) * | 1996-03-13 | 1999-04-07 | 隆萨股份公司 | N-保护d-脯氨酸衍生物的制备方法 |
CZ213199A3 (cs) * | 1996-12-16 | 1999-11-17 | Lonza Ag | Mikroorganismy, enzymy a způsob výroby derivátů D-prolinu |
HN2002000136A (es) * | 2001-06-11 | 2003-07-31 | Basf Ag | Inhibidores de la proteasa del virus hiv, compuestos que contienen a los mismos, sus usos farmaceuticos y los materiales para su sintesis |
-
2004
- 2004-11-22 CA CA002549289A patent/CA2549289A1/en not_active Abandoned
- 2004-11-22 CN CNA2004800358020A patent/CN101068780A/zh active Pending
- 2004-11-22 WO PCT/IB2004/003812 patent/WO2005054186A2/en not_active Application Discontinuation
- 2004-11-22 EP EP04798935A patent/EP1737818A2/en not_active Withdrawn
- 2004-11-22 JP JP2006542037A patent/JP2007521801A/ja not_active Withdrawn
- 2004-11-22 AU AU2004295187A patent/AU2004295187A1/en not_active Abandoned
- 2004-11-22 BR BRPI0417046-6A patent/BRPI0417046A/pt not_active IP Right Cessation
- 2004-11-22 KR KR1020067010848A patent/KR20060100457A/ko not_active Application Discontinuation
- 2004-11-22 RU RU2006119470/04A patent/RU2006119470A/ru unknown
- 2004-12-03 US US11/003,830 patent/US20050192441A1/en not_active Abandoned
-
2006
- 2006-05-18 IL IL175737A patent/IL175737A0/en unknown
- 2006-06-01 CO CO06052852A patent/CO5700727A2/es not_active Application Discontinuation
- 2006-06-02 ZA ZA200604545A patent/ZA200604545B/en unknown
- 2006-06-23 NO NO20062944A patent/NO20062944L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1737818A2 (en) | 2007-01-03 |
NO20062944L (no) | 2006-09-04 |
CO5700727A2 (es) | 2006-11-30 |
WO2005054186A3 (en) | 2007-04-19 |
KR20060100457A (ko) | 2006-09-20 |
CA2549289A1 (en) | 2005-06-16 |
IL175737A0 (en) | 2006-09-05 |
AU2004295187A1 (en) | 2005-06-16 |
JP2007521801A (ja) | 2007-08-09 |
ZA200604545B (en) | 2007-10-31 |
US20050192441A1 (en) | 2005-09-01 |
WO2005054186A2 (en) | 2005-06-16 |
RU2006119470A (ru) | 2007-12-20 |
CN101068780A (zh) | 2007-11-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 4A., 5A., 6A. E 7A. ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 4A, 5A, 6A E 7A ANUIDADES. |