RS54736B1 - Postupak za sintezu derivata 3,6-dihidro-1,3,5-triazina - Google Patents

Postupak za sintezu derivata 3,6-dihidro-1,3,5-triazina

Info

Publication number
RS54736B1
RS54736B1 RS20160296A RSP20160296A RS54736B1 RS 54736 B1 RS54736 B1 RS 54736B1 RS 20160296 A RS20160296 A RS 20160296A RS P20160296 A RSP20160296 A RS P20160296A RS 54736 B1 RS54736 B1 RS 54736B1
Authority
RS
Serbia
Prior art keywords
compound
formula
dihydro
synthesis
triazine derivatives
Prior art date
Application number
RS20160296A
Other languages
English (en)
Inventor
Stéphanie AUBOURG
Bernard Boudet
Daniel Cravo
Matthias Helmreich
Original Assignee
Poxel Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poxel Sas filed Critical Poxel Sas
Publication of RS54736B1 publication Critical patent/RS54736B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/10—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Postupak za dobijanje jedinjenja formule Iu kojojR je metil, fenil, 4-hidroksi-fenil ili 4-metoksifenili njegove farmaceutske soli, tautomera i stereoizomera, naznačen time, što jedinjenje formule IIi njegove solireaguje sa jedinjenjem formule IIIR-CHO III u kojoj je R kao što je prethodno definisano,u polarnom rastvaraču ili smeši rastvarača u prisustvu neorganske i/ili organske baze odabrane iz grupekoju čine K2CO3, NaHCO3, NaOMe, Na2CO3, piperidin, i morfolin.Prijava sadrži još 10 patentnih zahteva.
RS20160296A 2008-05-23 2009-04-24 Postupak za sintezu derivata 3,6-dihidro-1,3,5-triazina RS54736B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08009483 2008-05-23
EP09749530.3A EP2300444B1 (en) 2008-05-23 2009-04-24 Process for the synthesis of 3,6-dihydro-1,3,5-triazine derivatives
PCT/EP2009/002997 WO2009141040A2 (en) 2008-05-23 2009-04-24 Process for the synthesis of 3,6-dihydro-1,3,5-triazine derivatives

Publications (1)

Publication Number Publication Date
RS54736B1 true RS54736B1 (sr) 2016-10-31

Family

ID=40791625

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20160296A RS54736B1 (sr) 2008-05-23 2009-04-24 Postupak za sintezu derivata 3,6-dihidro-1,3,5-triazina

Country Status (21)

Country Link
US (1) US20110124860A1 (sr)
EP (1) EP2300444B1 (sr)
JP (1) JP5458093B2 (sr)
KR (1) KR101618198B1 (sr)
CN (1) CN102036970A (sr)
AU (1) AU2009250149B2 (sr)
BR (1) BRPI0912512B1 (sr)
CA (1) CA2725011A1 (sr)
CY (1) CY1117855T1 (sr)
DK (1) DK2300444T3 (sr)
EA (1) EA018921B1 (sr)
ES (1) ES2571793T3 (sr)
HR (1) HRP20160414T1 (sr)
HU (1) HUE027532T2 (sr)
IL (1) IL209198A (sr)
MX (1) MX2010012741A (sr)
PL (1) PL2300444T3 (sr)
RS (1) RS54736B1 (sr)
SI (1) SI2300444T1 (sr)
WO (1) WO2009141040A2 (sr)
ZA (1) ZA201009160B (sr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5758010B2 (ja) 2010-12-01 2015-08-05 ポクセルＰｏｘｅｌ 酒石酸によるトリアジン誘導体エナンチオマーの分離
CN105753801B (zh) * 2016-03-25 2018-06-01 浙江工业大学 一种均三嗪类化合物的制备方法
JP2020536121A (ja) 2017-10-02 2020-12-10 ポクセルＰｏｘｅｌ 駆出率が保持された心不全を治療する方法
AU2019282727A1 (en) 2018-06-06 2020-11-26 Metavant Sciences Gmbh Methods of treating subjects having diabetes with chronic kidney disease
EP3806828A1 (en) 2018-06-14 2021-04-21 Poxel Film-coated tablet comprising a triazine derivative for use in the treatment of diabetes
CN114681464B (zh) * 2020-12-28 2024-07-09 南京理工大学 二甲双胍类似物在制备脑缺血再灌注损伤预防和治疗药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2804113B1 (fr) * 2000-01-26 2004-06-18 Lipha Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique
AU2003289375A1 (en) * 2002-12-17 2004-07-09 Hamari Chemicals, Ltd Novel 2,4-diamino-1,3,5-triazine derivative
FR2853650B1 (fr) * 2003-04-10 2006-07-07 Merck Sante Sas Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance
DE102007054416A1 (de) * 2007-11-13 2009-05-14 Studiengesellschaft Kohle Mbh Verfahren zur Herstellung von 3,6-Dihydro-1,3,5- Triazin-Derivaten für die Behandlungen von Erkrankungen, die mit dem Insulinresistenz-Syndrom assoziiert sind

Also Published As

Publication number Publication date
CY1117855T1 (el) 2017-05-17
EP2300444B1 (en) 2016-04-13
ZA201009160B (en) 2011-10-26
BRPI0912512A2 (pt) 2015-07-28
EA201001828A1 (ru) 2011-04-29
MX2010012741A (es) 2010-12-21
BRPI0912512B1 (pt) 2018-09-11
HUE027532T2 (en) 2016-10-28
HRP20160414T1 (hr) 2016-05-20
IL209198A (en) 2013-11-28
WO2009141040A2 (en) 2009-11-26
JP5458093B2 (ja) 2014-04-02
SI2300444T1 (sl) 2016-10-28
WO2009141040A3 (en) 2010-01-21
KR101618198B1 (ko) 2016-05-04
AU2009250149B2 (en) 2013-05-23
IL209198A0 (en) 2011-01-31
KR20110013498A (ko) 2011-02-09
EA018921B1 (ru) 2013-11-29
CA2725011A1 (en) 2009-11-26
DK2300444T3 (en) 2016-05-23
AU2009250149A1 (en) 2009-11-26
CN102036970A (zh) 2011-04-27
ES2571793T3 (es) 2016-05-26
US20110124860A1 (en) 2011-05-26
EP2300444A2 (en) 2011-03-30
PL2300444T3 (pl) 2016-08-31
JP2011520930A (ja) 2011-07-21

Similar Documents

Publication Publication Date Title
RS51795B (sr) 2-amino-7,8-dihidro-6h-pirido[4,3-d]pirimidin-5-oni, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže
RS54506B1 (sr) Derivati pikolinamida kao inhibitori kinaza
EA201001682A1 (ru) Производные фенил- и бензодиоксинилзамещенных индазолов
RS52261B (sr) Amidofenoksi indazoli kao korisni inhibitori c-met-a
AR094346A1 (es) Derivados de azaindol como inhibidores de las proteína quinasas
EA201000113A1 (ru) Пиразольные соединения
EA200701176A1 (ru) Новые соединения нафталина, способ их получения и фармацевтические композиции, содержащие их
EA200970156A1 (ru) Пиридизиноновые производные
RS52953B (sr) Piridopirimidinonski inhibitori pi3 kalfa
RS52534B (sr) Makrociklična jedinjenja hinoksalina kao inhibitori hcv ns3 proteaze
DK2091948T3 (da) Nye inhibitorer af glutaminylcyclase
NO20091553L (no) Fenylderivater og deres anvendelse som immunmodulatorer
BRPI0810929B8 (pt) uso de um composto de fórmula 1
EA201000947A1 (ru) Производные тиазола, применимые в качестве ингибиторов киназы pi3
RS54736B1 (sr) Postupak za sintezu derivata 3,6-dihidro-1,3,5-triazina
PE20141167A1 (es) Piridopirazinas sustituidas como inhibidores novedosos de ptk
EA201391558A1 (ru) Тетрагидропиразоло[1,5-а]пиримидины как противотуберкулезные соединения
EA201101334A1 (ru) Новые соединения бензотиадиазепина, способ их приготовления и фармацевтические композиции, содержащие их
RS53613B1 (sr) Jedinjenja, kompozicije i postupci za tretman beta-amiloidnih bolesti i sinukleinopatija
EA201071012A1 (ru) Производные азетидинов, способ их получения и применение их в терапии
WO2007147771A3 (en) Tetralin and indane derivatives and uses thereof
PE20110213A1 (es) Derivados de indolinona como inhibidores de quinasa
CR10722A (es) Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintetasa quinasa 3
MX2010003849A (es) Antagonistas de cgrp.
DK1893589T3 (da) Substituerede N-benzo[d]isoxazol-3-yl-amin-derivater som inhibitorer af mGluR5-, serotonin-(5-HT) og noradrenalinreceptorer og deres anvendelse til fremstilling af lægemidler