CO5700727A2 - Procedimientos para preparar aminas enriquecidas estereoisomericamente - Google Patents

Procedimientos para preparar aminas enriquecidas estereoisomericamente

Info

Publication number
CO5700727A2
CO5700727A2 CO06052852A CO06052852A CO5700727A2 CO 5700727 A2 CO5700727 A2 CO 5700727A2 CO 06052852 A CO06052852 A CO 06052852A CO 06052852 A CO06052852 A CO 06052852A CO 5700727 A2 CO5700727 A2 CO 5700727A2
Authority
CO
Colombia
Prior art keywords
aryl
alkyl
cr7r8
halo
hydrogen
Prior art date
Application number
CO06052852A
Other languages
English (en)
Inventor
Shanghui Hu
Carlos Alberto Martinez
Junhua Tao
Yazbeck Daniel Rida
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CO5700727A2 publication Critical patent/CO5700727A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

1.- Un procedimiento para preparar un compuesto enriquecido estereoisoméricamente de fórmula (I) en la que Z es O, S, C=O, C=CH2, o -(CR7R8)-;R1 es hidrógeno, -(CR7R8)-t(arilo C6-C14), -CH2-CH=CH2, -C(O)R7, -C(O)OR7, -C(O)C(O)OR7 o -Si(R7)3, en la que dicho arilo C6-C14 está opcionalmente sustituido con al menos un sustituyente seleccionado de halo, alquilo C1-C10, OR7 y -N(R7R8);R2 y R3 se seleccionan independientemente de hidrógeno, alquilo C1-C10, alquenilo C2-C10, alquinilo C2-C10, -(CR7R8)-t(arilo C6-C14) y -(CR7R8)t(heterociclo de 4-10 miembros), en la que el arilo C6-C14 y el heterociclo de 4-10 miembros están opcionalmente sustituidos con al menos un sustituyente seleccionado de halo, alquilo C1-C10, OR7, y -N(R7R8);R4 y R5 se seleccionan independientemente de hidrógeno, halo, alquilo C1-C10, alquenilo C2-C10, alquinilo C2-C10, -(CR7R8)-t(arilo C6-C14) y -(CR7R8)t(heterociclo de 4-10 miembros), en la que el arilo C6-C14 y el heterociclo de 4-10 miembros están opcionalmente sustituidos con al menos un sustituyente seleccionado de halo, alquilo C1-C10, -OR7, y -N(R7R8);R6 es hidrógeno;R7 y R8 se seleccionan cada uno independientemente de hidrógeno, halo, alquilo C1-C10, alcoxi C1-C10, alquenilo C2-C10, alquinilo C2-C10, -(CR9R9)t(arilo C6-C14) y -(CR9R9)-t(heterociclo de 4-10 miembros), en la que el arilo C6-C14 y el heterociclo de 4-10 miembros están opcionalmente sustituidos con al menos un sustituyente seleccionado de halo, alquilo C1-C10, -OR9, y -N(R9R9);cada R9 se selecciona independientemente de hidrógeno y alquilo C1-C10; y t es un número entero de 0 a 5;comprendiendo dicho procedimiento:tratar un compuesto de fórmula (I), en la que R1, R2, R3, R4 y R5 son tal como se han definido anteriormente y R6 se selecciona de alquilo C1-C10, alquenilo C2-C10, alquinilo C2-C10, -(CR7R8)-t(arilo C6-C14) y -(CR7R8)t(heterociclo de 4-10 miembros), y en la que dicho arilo C6-C14 y dicho heterociclo de 4-10 miembros están opcionalmente sustituidos con al menos un sustituyente seleccionado de halo, alquilo C1-C10, OR7, y -N(R7R8), con un biocatalizador en una solución acuosa, un disolvente orgánico, o una mezcla de disolventes orgánico y acuoso en la que se hidroliza selectivamente al menos un estereoisómero.
CO06052852A 2003-12-04 2006-06-01 Procedimientos para preparar aminas enriquecidas estereoisomericamente CO5700727A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52714303P 2003-12-04 2003-12-04

Publications (1)

Publication Number Publication Date
CO5700727A2 true CO5700727A2 (es) 2006-11-30

Family

ID=34652482

Family Applications (1)

Application Number Title Priority Date Filing Date
CO06052852A CO5700727A2 (es) 2003-12-04 2006-06-01 Procedimientos para preparar aminas enriquecidas estereoisomericamente

Country Status (14)

Country Link
US (1) US20050192441A1 (es)
EP (1) EP1737818A2 (es)
JP (1) JP2007521801A (es)
KR (1) KR20060100457A (es)
CN (1) CN101068780A (es)
AU (1) AU2004295187A1 (es)
BR (1) BRPI0417046A (es)
CA (1) CA2549289A1 (es)
CO (1) CO5700727A2 (es)
IL (1) IL175737A0 (es)
NO (1) NO20062944L (es)
RU (1) RU2006119470A (es)
WO (1) WO2005054186A2 (es)
ZA (1) ZA200604545B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007026875A1 (ja) * 2005-09-02 2007-03-08 Ube Industries, Ltd. 光学活性（Ｓ又はＲ）－α－ヒドロキシ酸及び光学活性（Ｒ又はＳ）－α－ヒドロキシ酸エステルの製造方法
CN101284797B (zh) * 2008-06-11 2010-08-11 常州恩滋生物科技有限公司 N-保护的烯丙基甘氨酸酯的拆分方法
EP2373977A1 (en) * 2008-12-17 2011-10-12 The Lubrizol Corporation Optically active functional fluid markers
RU2014106109A (ru) * 2011-07-20 2015-08-27 Эвоник Дегусса Гмбх Окисление и аминирование первичных спиртов

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5644028A (en) * 1992-05-13 1997-07-01 Japan Energy Corporation Process for producing peptide derivatives and salts therefor
US5932550A (en) * 1995-06-30 1999-08-03 Japan Energy Corporation Dipeptide compound or pharmaceutically acceptable salt thereof and medical use thereof
US6222043B1 (en) * 1995-06-30 2001-04-24 Japan Energy Corporation Methods of preparing novel dipeptide compounds or pharmaceutically acceptable salts thereof
CA2245543A1 (en) * 1996-03-13 1997-09-18 Fabienne Henzen Process for producing n-protected d-proline derivatives 8
AU5757498A (en) * 1996-12-16 1998-07-15 Lonza A.G. Method for production of d-proline derivatives
HN2002000136A (es) * 2001-06-11 2003-07-31 Basf Ag Inhibidores de la proteasa del virus hiv, compuestos que contienen a los mismos, sus usos farmaceuticos y los materiales para su sintesis

Also Published As

Publication number Publication date
ZA200604545B (en) 2007-10-31
JP2007521801A (ja) 2007-08-09
KR20060100457A (ko) 2006-09-20
IL175737A0 (en) 2006-09-05
WO2005054186A2 (en) 2005-06-16
US20050192441A1 (en) 2005-09-01
BRPI0417046A (pt) 2007-02-06
RU2006119470A (ru) 2007-12-20
CN101068780A (zh) 2007-11-07
EP1737818A2 (en) 2007-01-03
NO20062944L (no) 2006-09-04
AU2004295187A1 (en) 2005-06-16
WO2005054186A3 (en) 2007-04-19
CA2549289A1 (en) 2005-06-16

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