AR062680A1 - Sintesis de 2-(piridin-2-ilamino) pirido [2,3-d] pirimidin-7-onas - Google Patents

Sintesis de 2-(piridin-2-ilamino) pirido [2,3-d] pirimidin-7-onas

Info

Publication number
AR062680A1
AR062680A1 ARP070103937A ARP070103937A AR062680A1 AR 062680 A1 AR062680 A1 AR 062680A1 AR P070103937 A ARP070103937 A AR P070103937A AR P070103937 A ARP070103937 A AR P070103937A AR 062680 A1 AR062680 A1 AR 062680A1
Authority
AR
Argentina
Prior art keywords
compound
cr7r8
alkyl
formula
cycloalkyl
Prior art date
Application number
ARP070103937A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR062680A1 publication Critical patent/AR062680A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

Utiles en tratamiento de trastornos proliferativos celulares o una sal farmacéuticamente aceptables de las mismas. Reivindicacion 1: Un procedimiento para preparar un compuesto de formula (1) que comprende las etapas de (a) hacer resccionar un compuesto de formula (2) con un compuesto de formula (3) en la que R1 es hidrogeno, alquilo C1-6, haloalquilo C1-6, hidroxialquilo C1-6 o cicloalquilo C3-7; R2 es Br o I; R3 es hidrogeno, OH, -NH2, arilo, alquilo C1-8, cicloalquilo C3-7 o heterociclilo C3-7; R4 es -R5-PG seleccionado del grupo constituido por -(CR7R8)m-N(PG)R7 y -(CR7R8)m-(heterociclo de 3 a 10 miembros que comprende un átomo de anillo de N protegido con PG), y PG es un grupo protector de amino lábil a los ácidos; R5, que es R4 sin PG, es -(CR7R8)mNR7- o -(CR7R8)m-(heterociclo de 3 a 10 miembros que comprende un átomo de anillo de N), en el que m es 0, 1, 2 o 3; R6 es alquilo C1-6; y cada R7 y R8 es independientemente H o alquilo C1-6; en presencia de un catalizador de metal de transicion, una base y opcionalmente un agente de fosfina, y en un disolvente adecuado para formar un compuesto de formulas (4) o (5); y (b) haciendo reaccionar posteriormente el compuesto de formulas 4 o 5 o la mezcla de los mismos, con ácido isetionico en un disolvente adecuado.
ARP070103937A 2006-09-08 2007-09-06 Sintesis de 2-(piridin-2-ilamino) pirido [2,3-d] pirimidin-7-onas AR062680A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84305106P 2006-09-08 2006-09-08
US94210407P 2007-06-05 2007-06-05

Publications (1)

Publication Number Publication Date
AR062680A1 true AR062680A1 (es) 2008-11-26

Family

ID=38988315

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070103937A AR062680A1 (es) 2006-09-08 2007-09-06 Sintesis de 2-(piridin-2-ilamino) pirido [2,3-d] pirimidin-7-onas

Country Status (15)

Country Link
US (1) US7781583B2 (es)
EP (1) EP2069344A2 (es)
JP (1) JP2008094834A (es)
KR (1) KR20090052385A (es)
CN (1) CN101511829A (es)
AR (1) AR062680A1 (es)
AU (1) AU2007297286A1 (es)
BR (1) BRPI0716880A2 (es)
CA (1) CA2662768A1 (es)
IL (1) IL197242A0 (es)
MX (1) MX2009002069A (es)
RU (1) RU2009108006A (es)
TW (1) TW200821309A (es)
WO (1) WO2008032157A2 (es)
ZA (1) ZA200901270B (es)

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Family Cites Families (2)

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NZ544609A (en) * 2003-07-11 2008-07-31 Warner Lambert Co Isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

Also Published As

Publication number Publication date
CA2662768A1 (en) 2008-03-20
BRPI0716880A2 (pt) 2013-10-15
RU2009108006A (ru) 2010-10-20
US7781583B2 (en) 2010-08-24
WO2008032157A2 (en) 2008-03-20
JP2008094834A (ja) 2008-04-24
ZA200901270B (en) 2010-05-26
KR20090052385A (ko) 2009-05-25
AU2007297286A1 (en) 2008-03-20
EP2069344A2 (en) 2009-06-17
MX2009002069A (es) 2009-03-06
CN101511829A (zh) 2009-08-19
WO2008032157A3 (en) 2008-10-23
TW200821309A (en) 2008-05-16
US20080125588A1 (en) 2008-05-29
IL197242A0 (en) 2009-12-24

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