AR084337A1 - Azaindoles como agentes antivirales del virus respiratorio sincicial - Google Patents
Azaindoles como agentes antivirales del virus respiratorio sincicialInfo
- Publication number
- AR084337A1 AR084337A1 ARP110104742A ARP110104742A AR084337A1 AR 084337 A1 AR084337 A1 AR 084337A1 AR P110104742 A ARP110104742 A AR P110104742A AR P110104742 A ARP110104742 A AR P110104742A AR 084337 A1 AR084337 A1 AR 084337A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- cycloalkyl
- alkoxy
- halogen
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Azaindoles que tiene actividad inhibitoria sobre la replicación de VRS y composiciones que contienen estos compuestos como ingrediente activo y procesos para preparar estos componentes y composiciones.Reivindicación 1: Un compuesto que satisface la fórmula (1), un profármaco, un N-óxido, una sal por adición, una amina cuaternaria, un complejo metálico, o una de sus formas estereoquímicamente isoméricas; donde cada X independientemente es C o N con al menos un X que es N; R1 está presente cuando X = C y R1 se selecciona del grupo de H, OH, halógeno, alquilo C1-6, cicloalquilo C3-7, alcoxi C1-6, N(R6)2, CO(R7), CH2NH2, CH2OH, CN, C(=NOH)NH2, C(=NOCH3)NH2, C(=NH)NH2, CF3, OCF3, y B(OH)2; B(O-alquil C1-6)2; R2 se selecciona del grupo que consiste en H, halógeno, alquilo C1-6, cicloalquilo C3-7, alcoxi C1-6, y CO(R7); R3 es -(CR8R9)n-R10; R4 se selecciona del grupo que consiste en H, alquilo C1-10, CH2CF3 cicloalquilo C3-7, alquenilo C2-10, SO2-R8, o un anillo saturado de 4 a 6 miembros que contiene un átomo de oxígeno; R5 está presente cuando Y es C, y se selecciona del grupo que consiste en H, alquilo C1-6, cicloalquilo C3-7, alcoxi C1-6, CO(R7), CF3 y halógeno; R5 está ausente cuando X es N; R6 se selecciona del grupo que consiste en H, alquilo C1-6, COOCH3, y CONHSO2CH3; R7 se selecciona del grupo que consiste en OH, O(alquilo C1-6), NH2, NHSO2N(alquilo C1-6)2, NHSO2NHCH3, NHSO2(alquilo C1-6), NHSO2(cicloalquilo C3-7), y N(alquilo C1-6)2; n es un número entero de 2 a 6; R8 y R9 se seleccionan independientemente entre H, alquilo C1-10, cicloalquilo C3-7 o R8 y R9 tomados en conjunto forman un anillo alifático de 4 a 6 miembros que opcionalmente contiene un heteroátomo seleccionado del grupo N, S, O; R10 se selecciona del grupo que consiste en H, alquilo C1-6, OH, CN, F, CF2H, CF3, CONR8R9, COOR8, CONR8SO2R9, CON(R8)SO2N(R8R9), NR8R9, NR8COOR9, OCOR8, NR8SO2R9, SO2NR8R9, SO2R8 o un anillo saturado de 4 a 6 miembros que contiene un átomo de oxígeno.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10195473 | 2010-12-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR084337A1 true AR084337A1 (es) | 2013-05-08 |
Family
ID=43920170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110104742A AR084337A1 (es) | 2010-12-16 | 2011-12-16 | Azaindoles como agentes antivirales del virus respiratorio sincicial |
Country Status (12)
Country | Link |
---|---|
US (3) | US9051317B2 (es) |
EP (1) | EP2651936B1 (es) |
JP (1) | JP5876502B2 (es) |
KR (1) | KR101876791B1 (es) |
CN (1) | CN103339128B (es) |
AR (1) | AR084337A1 (es) |
AU (1) | AU2011343259B2 (es) |
CA (1) | CA2822002C (es) |
EA (1) | EA025402B1 (es) |
ES (1) | ES2624263T3 (es) |
TW (1) | TWI501967B (es) |
WO (1) | WO2012080450A1 (es) |
Families Citing this family (34)
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TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
TWI541241B (zh) | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
TWI527814B (zh) * | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
AU2013276519B2 (en) | 2012-06-15 | 2017-05-25 | Janssen Sciences Ireland Uc | 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents |
US20150158862A1 (en) * | 2012-06-15 | 2015-06-11 | Janssen R&D Ireland | 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents |
MX363717B (es) | 2012-10-16 | 2019-03-29 | Janssen Sciences Ireland Uc | Compuestos antiviricos para el virus sincitial respiratorio. |
WO2014111871A1 (en) | 2013-01-17 | 2014-07-24 | Aurigene Discovery Technologies Limited | 4,5-dihydroisoxazole derivatives as nampt inhibitors |
RU2015148926A (ru) | 2013-05-14 | 2017-06-15 | Ф. Хоффманн-Ля Рош Аг | Аза-оксо-индолы для лечения и профилактики респираторно-синцитиальной вирусной инфекции |
CN105392787B (zh) * | 2013-05-14 | 2017-11-24 | 豪夫迈·罗氏有限公司 | 用于治疗和预防呼吸道合胞病毒感染的氮杂‑氧代‑吲哚 |
CN105408330A (zh) * | 2013-08-12 | 2016-03-16 | 豪夫迈·罗氏有限公司 | 新的用于治疗和预防呼吸道合胞病毒感染的氮杂-氧代-吲哚 |
CA2914529A1 (en) * | 2013-08-12 | 2015-02-19 | F. Hoffmann-La Roche Ag | Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
BR112016003348B1 (pt) | 2013-08-21 | 2023-03-07 | Alios Biopharma, Inc | Compostos antivirais ou sais farmaceuticamente aceitáveis dos mesmos, composição farmacêutica e seus usos |
TWI671299B (zh) | 2014-04-14 | 2019-09-11 | 愛爾蘭商健生科學愛爾蘭無限公司 | 作為rsv抗病毒化合物之螺脲化合物 |
US20160045528A1 (en) * | 2014-08-05 | 2016-02-18 | Alios Biopharma, Inc. | Combination therapy for treating a paramyxovirus |
MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
MX2018000916A (es) | 2015-07-22 | 2018-09-05 | Enanta Pharm Inc | Derivados de benzodiazepina como inhibidores de rsv. |
BR112018010216B1 (pt) | 2015-11-20 | 2024-02-15 | Forma Therapeutics, Inc | Purinonas como inibidores da protease específica da ubiquitina 1 e composição farmacêutica compreendendo os referidos compostos |
US20170226129A1 (en) | 2016-01-15 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
US9781457B1 (en) | 2016-03-31 | 2017-10-03 | Google Inc. | Methods, systems, and media for indicating viewership of a video based on context |
EP3582784B1 (en) | 2017-02-16 | 2022-06-08 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of benzodiazepine derivatives |
US11091501B2 (en) | 2017-06-30 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
WO2019067864A1 (en) | 2017-09-29 | 2019-04-04 | Enanta Pharmaceuticals, Inc. | PHARMACEUTICAL AGENTS IN COMBINATION AS INHIBITORS OF RSV |
AU2018365174B2 (en) | 2017-11-13 | 2023-03-30 | Enanta Pharmaceuticals, Inc. | Processes for the resolution of benzodiazepin-2-one and benzoazepin-2-one derivatives |
EP3897670A4 (en) | 2018-12-19 | 2022-09-07 | Disarm Therapeutics, Inc. | MRSA1 INHIBITORS IN COMBINATION WITH NEUROPROTECTIVE AGENTS |
US11254664B2 (en) | 2019-03-18 | 2022-02-22 | Enanta Pharmaceuticals, Inc. | Benzodiazepine derivatives as RSV inhibitors |
KR20220101083A (ko) | 2019-10-04 | 2022-07-19 | 이난타 파마슈티칼스, 인코포레이티드 | 항바이러스 헤테로사이클릭 화합물 |
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TWI530495B (zh) * | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
TWI515187B (zh) * | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
TWI527814B (zh) * | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
TWI541241B (zh) * | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
CA2821367A1 (en) | 2010-12-17 | 2012-06-21 | Sanofi-Aventis Deutschland Gmbh | Medicament administration |
EA201590020A1 (ru) * | 2012-06-15 | 2015-03-31 | ЯНССЕН Ар ЭНД Ди АЙРЛЭНД | Новые производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные бензимидазолами, в качестве противовирусных средств против респираторного синцитиального вируса |
US20150158862A1 (en) * | 2012-06-15 | 2015-06-11 | Janssen R&D Ireland | 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents |
KR20150028969A (ko) * | 2012-06-15 | 2015-03-17 | 얀센 알 앤드 디 아일랜드 | 호흡기 합포체 바이러스의 항바이러스제로서의 벤즈이미다졸로 치환된 4-치환된 1,3-디하이드로-2h-벤즈이미다졸-2-온 유도체 |
AU2013276519B2 (en) * | 2012-06-15 | 2017-05-25 | Janssen Sciences Ireland Uc | 1,3-dihydro-2H-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents |
MX363717B (es) * | 2012-10-16 | 2019-03-29 | Janssen Sciences Ireland Uc | Compuestos antiviricos para el virus sincitial respiratorio. |
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2011
- 2011-12-15 TW TW100146389A patent/TWI501967B/zh not_active IP Right Cessation
- 2011-12-16 AU AU2011343259A patent/AU2011343259B2/en not_active Ceased
- 2011-12-16 JP JP2013543804A patent/JP5876502B2/ja active Active
- 2011-12-16 CA CA2822002A patent/CA2822002C/en active Active
- 2011-12-16 US US13/993,543 patent/US9051317B2/en active Active
- 2011-12-16 AR ARP110104742A patent/AR084337A1/es unknown
- 2011-12-16 WO PCT/EP2011/073016 patent/WO2012080450A1/en active Application Filing
- 2011-12-16 ES ES11799682.7T patent/ES2624263T3/es active Active
- 2011-12-16 EP EP11799682.7A patent/EP2651936B1/en active Active
- 2011-12-16 CN CN201180060368.1A patent/CN103339128B/zh active Active
- 2011-12-16 EA EA201390885A patent/EA025402B1/ru not_active IP Right Cessation
- 2011-12-16 KR KR1020137016526A patent/KR101876791B1/ko active IP Right Grant
-
2015
- 2015-05-05 US US14/704,292 patent/US9339494B2/en active Active
-
2016
- 2016-05-12 US US15/153,591 patent/US9896459B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20130267556A1 (en) | 2013-10-10 |
US9339494B2 (en) | 2016-05-17 |
EP2651936A1 (en) | 2013-10-23 |
JP2013545787A (ja) | 2013-12-26 |
KR20140014093A (ko) | 2014-02-05 |
ES2624263T3 (es) | 2017-07-13 |
CA2822002A1 (en) | 2012-06-21 |
EP2651936B1 (en) | 2017-02-22 |
US9051317B2 (en) | 2015-06-09 |
EA025402B1 (ru) | 2016-12-30 |
CA2822002C (en) | 2019-08-06 |
US20160251377A1 (en) | 2016-09-01 |
CN103339128A (zh) | 2013-10-02 |
TWI501967B (zh) | 2015-10-01 |
EA201390885A1 (ru) | 2013-09-30 |
KR101876791B1 (ko) | 2018-08-09 |
AU2011343259B2 (en) | 2014-11-27 |
AU2011343259A1 (en) | 2013-05-02 |
CN103339128B (zh) | 2015-11-25 |
TW201305158A (zh) | 2013-02-01 |
WO2012080450A1 (en) | 2012-06-21 |
JP5876502B2 (ja) | 2016-03-02 |
US20150231119A1 (en) | 2015-08-20 |
US9896459B2 (en) | 2018-02-20 |
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